SLCO1B1 rs4149056: what the research says
rs4149056
Pharmacogenomics
Strong evidenceGene: SLCO1B1The C allele of SLCO1B1 increases the risk of muscle pain (myopathy) when taking the statin simvastatin. Discuss statin choice with your clinician.
About 15% of people carry two C alleles.
Our full long-form research profile for rs4149056 — genotype interpretations, evidence review, and FAQ — is being written and will appear on this page soon.
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rs4149015
SLCO1B1Pharmacogenomics
StrongA well-established variant that reduces the efficiency of statin transport into the liver, increasing the risk of muscle pain (myopathy).
rs4148211
SLCO1B1Pharmacogenomics
ModerateThis variant is associated with altered transport of various drugs, including statins, influencing clinical response and risk of myopathy.