ADCYAP1R1 rs1006417: Understanding Stress Response Genetics
The rs1006417 variant is a single nucleotide polymorphism located within the ADCYAP1R1 gene, which encodes a receptor involved in the body's stress response system. Research has investigated this variant for potential associations with stress-related conditions and cluster headache susceptibility.
What each genotype means
Typical genetic profile
This genotype represents the most common form of this genetic marker in many populations. Research investigating this specific variant in the context of cluster headache has not found a significant association with disease risk in studied cohorts. It is considered a neutral genetic variation in the context of current clinical literature.
This is the most common genotype observed in most global populations.
Typical genetic profile
This genotype represents a heterozygous state for this genetic marker. Studies examining this variant have not identified a clear link between this specific genetic profile and an increased risk for cluster headache or other stress-related conditions. It is generally regarded as a common, non-pathogenic variation.
This genotype is frequently observed across diverse ancestral groups.
Typical genetic profile
This genotype represents the alternative homozygous state for this marker. Current scientific evidence indicates that this variant does not significantly influence the risk of developing cluster headache. As with other genotypes for this marker, it is not currently considered a clinical indicator for specific health conditions.
This genotype is found at varying frequencies globally, though it is generally less common than the CC or CT genotypes in many populations.
What is rs1006417?
A single nucleotide polymorphism (SNP) is a variation at a single position in a DNA sequence among individuals. The variant rs1006417 is located within the ADCYAP1R1 gene, which stands for Adenylate Cyclase Activating Polypeptide 1 Receptor Type 1. This gene provides instructions for making a protein known as the PAC1 receptor. This receptor is a member of the G protein-coupled receptor family, which acts as a chemical messenger system on the surface of cells. By studying specific SNPs like rs1006417, researchers aim to understand how subtle differences in our genetic code might influence biological pathways, particularly those involved in how the brain and body process environmental signals and stress.
The Role of the ADCYAP1R1 Gene
The ADCYAP1R1 gene is critical for the function of the pituitary adenylate cyclase-activating polypeptide (PACAP) signaling pathway. PACAP is a neuropeptide that plays a significant role in the neuroendocrine regulation of the body's adaptive response to stress. The PAC1 receptor, encoded by ADCYAP1R1, is highly expressed in the hypothalamus and limbic structures of the brain—areas deeply involved in emotional regulation, fear processing, and the hypothalamic-pituitary-adrenal (HPA) axis. Because this pathway helps modulate how we respond to threatening or stressful stimuli, variations in the gene that encodes this receptor are of interest to scientists studying the biological underpinnings of stress-related mental health conditions and neurological disorders.
Research and Evidence Strength
The evidence linking rs1006417 to specific health outcomes is currently considered limited. While some studies have explored the broader ADCYAP1R1 gene in the context of post-traumatic stress disorder (PTSD) and cluster headaches, results for individual SNPs can be inconsistent across different populations. For instance, some research has identified sex-specific associations between other variants in this gene and PTSD, but these findings do not necessarily apply to every SNP in the region. Furthermore, genome-wide association studies (GWAS) have suggested that the ADCYAP1R1 region may be relevant to cluster headache pathogenesis, but these associations often require further validation in larger, more diverse cohorts. It is important to recognize that genetic associations are statistical in nature and do not imply a direct cause-and-effect relationship for any individual.
Population Frequency
The rs1006417 variant is classified as a common SNP, meaning it is found at a relatively high frequency across various global populations. Because it is common, it is present in a large portion of the general population, regardless of ancestry. This high frequency is typical for many non-coding or regulatory variants that do not have a strong, singular impact on health, but rather contribute to the natural spectrum of human genetic diversity.
Interpreting Genetic Information
Genetic information regarding variants like rs1006417 should be viewed as a small piece of a much larger puzzle. Because the evidence for this specific variant is limited, it cannot be used to predict an individual's health outcomes or risk for any condition. If you are concerned about stress-related symptoms, neurological issues, or your personal health history, it is essential to consult with a qualified healthcare professional. Never use genetic data to make medical decisions or change treatments without the guidance of a clinician. Genetic research is an evolving field, and while it provides valuable insights into human biology, it is not a substitute for professional medical evaluation and personalized care.
How common is this variant?
The rs1006417 variant is a common SNP found across diverse human populations.
Frequently asked questions
Is rs1006417 a diagnostic test for PTSD?
No, rs1006417 is not a diagnostic test for PTSD or any other condition. Genetic variants are statistical markers and cannot be used to diagnose complex mental health disorders.
Does this variant mean I will develop cluster headaches?
No, having a specific genotype for rs1006417 does not mean you will develop cluster headaches. Genetic associations are complex and influenced by many environmental and lifestyle factors.
Can I change my health risk based on this SNP?
You cannot change your genotype, but you can focus on overall wellness. Always discuss any health concerns or lifestyle changes with your primary care physician.
Where can I find more information on ADCYAP1R1?
You can find reliable information on the ADCYAP1R1 gene through resources like the NCBI Gene database or MedlinePlus Genetics. These sites provide comprehensive summaries of gene functions and related research.
Sources & further reading
Educational information only, last refreshed 9/24/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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