OR2M7 rs10153621: What Your Genotype Means
The rs10153621 variant is a single nucleotide polymorphism located within the OR2M7 gene. It is associated with individual differences in the ability to detect specific odorant metabolites in urine following the consumption of asparagus.
What each genotype means
Likely asparagus odor anosmia
You carry two copies of the non-sensing allele linked to olfactory receptor gene clusters including OR2M7. Genetic association studies indicate that individuals with this genotype are significantly less likely to detect the sulfurous metabolites in urine after consuming asparagus. This variation reflects normal sensory diversity and has no known adverse health consequences.
Carried by approximately 30% to 40% of individuals of European ancestry, with variation across different global ancestries.
Intermediate odor detection ability
You carry one copy of the allele associated with detecting asparagus urine metabolites and one copy linked to asparagus anosmia. Research suggests carriers typically retain the capacity to smell the distinctive scent, though detection sensitivity can vary between individuals. This is a harmless sensory trait and does not impact your health or metabolism.
Found in roughly 45% to 50% of populations of European descent.
Typical asparagus odor detection
You carry two copies of the allele associated with functioning olfactory detection of asparagus-derived sulfur compounds. Genome-wide studies show that people with this genotype are among the most likely to readily notice the characteristic odor in urine after eating asparagus. This reflects standard olfactory receptor signaling and has no medical implications.
Present in roughly 15% to 20% of people of European ancestry.
Understanding the rs10153621 Variant
The rs10153621 variant is a single nucleotide polymorphism (SNP), which is a variation at a single position in the DNA sequence. This specific SNP is located within the OR2M7 gene on chromosome 1. In the context of human genetics, SNPs are the most common type of genetic variation and can sometimes influence how our bodies interact with the environment. While many SNPs have no observable effect, others are studied for their potential to influence traits, such as sensory perception. The rs10153621 variant has been identified in research as a marker of interest regarding how individuals perceive certain chemical compounds. It is important to note that this variant is a tool for scientific study rather than a diagnostic indicator for any medical condition.
The Role of the OR2M7 Gene
The OR2M7 gene encodes an olfactory receptor, which is a type of protein that belongs to the large G-protein-coupled receptor (GPCR) family. Olfactory receptors are primarily expressed in the nose, where they interact with odorant molecules to initiate the neuronal signals that the brain interprets as smell. Because the olfactory receptor gene family is the largest in the human genome, these proteins are highly specialized to detect a vast array of chemical stimuli. By functioning as a molecular transducer, the OR2M7 protein converts the recognition of specific chemical structures into downstream signaling pathways. This process is fundamental to the sensory perception of smell and helps explain why individuals may have different sensitivities to various environmental odors, including those produced by metabolic processes in the body.
Research and Evidence Strength
Current research into rs10153621 is grounded in genome-wide association studies (GWAS), which look for correlations between specific genetic markers and observable traits. The evidence linking this variant to the detection of asparagus-related metabolites is considered limited. While some studies suggest that variations near or within the OR2M7 gene may contribute to differences in how people perceive these specific sulfur-containing compounds, the biological mechanisms are complex and involve multiple genetic and environmental factors. It is essential to recognize that 'association' in a GWAS does not necessarily mean 'causation.' The scientific community continues to investigate how these receptors function in real-world settings. Because the evidence is currently limited, findings should be viewed as an area of ongoing exploration rather than a definitive explanation of an individual's sensory capabilities.
Population Frequency and Interpretation
The frequency of the rs10153621 variant varies across different ancestral groups. In European populations, the minor allele frequency (MAF) is approximately 0.40, meaning the variant is relatively common. Understanding population frequency is a key component of genetic research, as it helps scientists determine if a trait is widespread or restricted to specific groups. However, knowing your genotype for this variant does not provide medical information or health guidance. Because this variant is associated with a sensory trait rather than a disease, it does not have clinical implications for your health or wellness. Readers should treat this information as a curiosity of human biological diversity. If you have questions about your sensory perception or any health concerns, it is always best to consult with a qualified healthcare professional.
How common is this variant?
The rs10153621 variant has a minor allele frequency of approximately 0.40 in European populations, indicating it is a common genetic variation.
Frequently asked questions
Is the OR2M7 gene related to any diseases?
Current scientific evidence does not link the OR2M7 gene to any specific diseases. Its primary known function is related to the sensory perception of smell.
Can I use this genetic information to change my diet?
No, this variant is associated with a sensory trait and has no clinical relevance to your nutritional needs or health. You should not make dietary changes based on this genetic information.
Why do some people smell asparagus in their urine and others do not?
The ability to detect these metabolites is influenced by both the production of the metabolites themselves and the sensitivity of an individual's olfactory receptors. Genetic variations in genes like OR2M7 may contribute to these differences in perception.
Is this test result a medical diagnosis?
No, this is not a medical diagnosis. Genetic variants associated with sensory traits are for educational purposes and do not provide information about your health status.
Sources & further reading
Educational information only, last refreshed 10/12/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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Associated with the specific anosmia or ability to perceive the pungent odor of asparagusic acid metabolites in human urine after asparagus consumption.
Strongly linked with the ability to smell methanethiol and other sulfurous metabolites in urine after asparagus consumption.
Variant in the olfactory receptor cluster linked to the specific anosmia or perception threshold of asparagus odorants in urine.
Variant in the olfactory receptor cluster strongly linked to the inability to smell the distinct odor of asparagus metabolites in urine (asparagus anosmia).