rs1016343: what the research says
This SNP located in the 8q24 chromosome region shows a strong association with prostate cancer risk in Chinese men.
What each genotype means
Lower prostate cancer risk
This genotype is associated with a lower statistical risk of developing prostate cancer compared to those carrying the T allele. Research indicates that the C allele is the more common, non-risk variant in many populations studied.
The C allele is the major allele with a global minor allele frequency of approximately 0.215, making the CC genotype the most common in many populations.
Increased prostate cancer risk
Carrying one copy of the T allele is associated with a statistically significant increase in prostate cancer risk compared to the CC genotype. This variant is located in the 8q24 region, a well-documented susceptibility locus for prostate cancer across multiple ancestries, including European, Asian, and African populations.
This heterozygous genotype is found in a significant portion of the population, with the T allele frequency reported at approximately 0.215.
Highest prostate cancer risk
Individuals with this genotype carry two copies of the T allele, which is associated with the highest statistical risk for prostate cancer among the three possible genotypes for this variant. Studies have shown that the effect size of this risk allele can vary by ancestry, with some populations showing a more pronounced association.
The TT genotype is the least common of the three, occurring at a frequency consistent with the minor allele frequency of approximately 0.215.
Not specified
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