SULT2A1 rs10426201: What Your Genotype Means
The rs10426201 variant is a single nucleotide polymorphism located within the SULT2A1 gene. It has been identified in metabolic genome-wide association studies as being linked to specific metabolite levels, particularly androstenediol monosulfate, in cohorts of elite athletes.
What each genotype means
Typical metabolite profile
This genotype represents the most common genetic configuration at this location. Research in elite athlete cohorts has linked this locus to variations in the levels of specific steroid metabolites, such as androstenediol monosulfate, though the functional impact on physical performance remains a subject of ongoing study.
This is the most common genotype across most global populations, with the G allele being the major allele in gnomAD data.
Intermediate metabolite profile
Carrying one copy of the A allele may influence the efficiency of steroid sulfation processes catalyzed by the SULT2A1 enzyme. While this variant has been identified in metabolic studies of elite athletes, it is not a diagnostic marker and does not determine athletic ability or health outcomes on its own.
This heterozygous genotype is found at varying frequencies globally, reflecting the presence of the less common A allele in diverse populations.
Variant metabolite profile
Individuals with this genotype carry two copies of the A allele, which has been associated with altered levels of specific circulating steroid sulfates in research settings. Because this variant is located in an intron of the SULT2A1 gene, its exact influence on enzyme activity is complex and may vary based on other genetic and environmental factors.
This genotype is less common than the GG or GA configurations, as the A allele is the minor allele in most studied populations.
Understanding the rs10426201 Variant
The rs10426201 variant is a specific genetic change located in the intronic region of the SULT2A1 gene. In genetics, an intronic variant sits within the non-coding sequences of a gene, which are regions that do not provide the direct instructions for building a protein but often play critical roles in regulating how genes are expressed. Researchers identify such variants through genome-wide association studies (GWAS), which scan the entire genome to find statistical links between specific DNA locations and observable traits or metabolic profiles. Because rs10426201 is located in a gene responsible for essential metabolic functions, scientists investigate it to understand how subtle differences in our DNA sequence might influence the body's internal chemical environment, particularly in individuals who push their physical limits, such as elite endurance athletes.
The Role of the SULT2A1 Gene
The SULT2A1 gene encodes an enzyme known as Sulfotransferase Family 2A Member 1. This enzyme is a specialized protein that catalyzes the process of sulfation, which involves adding a sulfate group to various molecules, including steroid hormones like DHEA and androstenediol. Sulfation is a fundamental biological process that alters the solubility and activity of these hormones, facilitating their transport through the circulatory system and their eventual elimination or storage. By regulating the levels of active versus sulfated steroids, SULT2A1 helps maintain hormonal homeostasis. Because these hormones are involved in numerous physiological pathways, including those related to metabolism and physical performance, variations in the SULT2A1 gene are of significant interest to researchers studying how the body manages its internal chemical resources during high-intensity exercise.
Research Associations and Evidence Strength
The evidence linking rs10426201 to physical performance is considered moderate and is primarily derived from metabolic GWAS (mGWAS) in elite athlete cohorts. Research has identified a novel association between this specific SNP and the levels of androstenediol (3alpha, 17alpha) monosulfate. This finding suggests that the variant may influence the efficiency of steroid sulfation pathways. However, it is important to note that while these statistical associations are significant within the context of the studies, they do not imply that this variant determines athletic success. The relationship between genetic markers and complex traits like athletic performance is influenced by thousands of other genetic and environmental factors. Furthermore, while some studies show clear genotype-dependent effects on metabolite levels, other research on SULT2A1 variants has shown mixed results regarding their impact on actual hormone concentrations in the blood, highlighting the complexity of these biological systems.
Interpreting Your Genetic Information
Information regarding genetic variants like rs10426201 is intended for educational purposes and should not be used to make medical decisions or to predict athletic potential. Genetic associations identified in research cohorts represent statistical trends across large groups of people and do not necessarily apply to an individual's health or performance. You cannot use this information to diagnose a condition or to determine a specific training regimen. If you are interested in how your genetics might influence your health or metabolic profile, it is best to consult with a qualified healthcare professional or a genetic counselor who can provide context based on your personal medical history. Always remember that lifestyle, training, nutrition, and environmental factors play a far more significant role in physical performance than any single genetic variant.
How common is this variant?
The frequency of this variant is primarily documented in specific research cohorts, such as elite athlete populations, and varies across different ancestral backgrounds.
Frequently asked questions
Does rs10426201 determine if I will be an elite athlete?
No. Athletic performance is a complex trait influenced by a vast combination of genetic, environmental, and training factors. A single genetic variant like rs10426201 cannot predict or determine athletic success.
What does the SULT2A1 gene do in the body?
The SULT2A1 gene provides instructions for making an enzyme that adds sulfate groups to steroid hormones. This process is important for regulating hormone activity and transport in the body.
Can I use this information to change my diet or supplements?
No. You should not use genetic information to make changes to your diet or supplement regimen. Always consult with a doctor or a registered dietitian before making significant changes to your health routine.
Is this variant associated with any diseases?
Current research focuses on the association between this variant and metabolite levels in athletes. There is no established evidence linking this specific variant to the diagnosis or risk of any specific disease.
Sources & further reading
Educational information only, last refreshed 10/31/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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