LPA rs10455874: Understanding Your Genetic Risk Factors
The rs10455874 variant is a genetic change located within the LPA gene, which provides instructions for making a protein involved in cholesterol transport. This specific variant is associated with elevated levels of lipoprotein(a) in the blood and an increased statistical risk for developing coronary artery disease and aortic valve stenosis.
What each genotype means
Typical lipoprotein(a) profile
This genotype is considered the common or reference state for this variant. Research indicates that individuals with this genotype generally do not carry the specific genetic signal associated with elevated lipoprotein(a) levels linked to this variant. As with all genetic findings, this does not preclude other factors from influencing your cardiovascular health.
This is the most common genotype, found in the vast majority of individuals across most global populations.
Increased lipoprotein(a) association
Carrying one copy of the T allele is associated with higher plasma lipoprotein(a) concentrations compared to those without it. Elevated lipoprotein(a) is recognized as a genetically determined risk factor for coronary heart disease and aortic valve stenosis. You should discuss your cardiovascular health and any relevant family history with your clinician.
This genotype is carried by approximately 1 in 7 to 1 in 8 people of European ancestry, though it is significantly less common in African and Asian populations.
Elevated lipoprotein(a) association
Carrying two copies of the T allele is associated with a more pronounced increase in plasma lipoprotein(a) levels. Research suggests that higher levels of lipoprotein(a) are linked to an increased risk of developing aortic valve stenosis and coronary heart disease. It is recommended that you discuss these findings and your overall cardiovascular risk profile with your healthcare provider.
This genotype is relatively rare, occurring in approximately 0.5% to 1% of individuals of European ancestry and is even less frequent in other global populations.
What is the rs10455874 Variant?
The rs10455874 variant is a single nucleotide polymorphism (SNP) located within the LPA gene on chromosome 6. In genetics, a SNP represents a variation at a single position in the DNA sequence. This particular variant is categorized as an intronic splice-affecting variant, meaning it sits in a non-coding region of the gene that helps regulate how the gene's instructions are processed. By influencing the splicing process, this variant can alter the production of apolipoprotein(a), a key component of lipoprotein(a) particles. Because it is located in a region that affects gene expression, it is frequently studied in the context of lipid metabolism and cardiovascular health. Researchers track this variant to understand how subtle changes in our genetic code can lead to measurable differences in blood chemistry and long-term health outcomes.
The Role of the LPA Gene
The LPA gene is responsible for producing apolipoprotein(a), which combines with other proteins to form lipoprotein(a), or Lp(a). Lipoprotein(a) is a type of low-density lipoprotein that circulates in the bloodstream. While the exact physiological function of Lp(a) is still being researched, it is well-established that high concentrations of this particle are linked to cardiovascular issues. The gene is complex, and its activity is heavily influenced by both the number of repeating segments it contains and specific variants like rs10455874. When the LPA gene is expressed, it influences the amount of Lp(a) that enters the circulation. Because Lp(a) levels are primarily determined by genetics rather than diet or lifestyle, variations in the LPA gene are considered primary drivers of an individual's baseline Lp(a) concentration.
Research and Statistical Associations
Scientific research has consistently identified a statistical association between the rs10455874 variant and higher plasma concentrations of lipoprotein(a). Large-scale genome-wide association studies (GWAS) have linked this variant to an increased risk of calcific aortic valve stenosis and coronary artery disease. The evidence suggests that the variant's effect on health is mediated through these elevated Lp(a) levels, which may contribute to the buildup of calcium and plaque in the heart's valves and arteries. It is important to note that while the association is statistically significant, the evidence strength for this specific variant's clinical impact is often described as limited in terms of direct diagnostic utility. Many factors contribute to heart health, and having this variant does not guarantee the development of disease. Research continues to explore how other biomarkers, such as inflammation, might modify the risk associated with this genetic profile.
Population Frequency
The frequency of the rs10455874 variant varies significantly across different ancestral groups. In European populations, the minor allele frequency is approximately 0.07, meaning it is present in a notable portion of the population. However, the variant is observed to be much rarer in African and Asian cohorts. This distribution highlights the importance of considering ancestry when interpreting genetic data, as the prevalence of specific risk-associated variants is not uniform globally. Understanding these frequency differences helps researchers conduct more accurate studies and ensures that genetic health insights are appropriately contextualized for diverse populations.
What You Can Do With This Information
Genetic information regarding the rs10455874 variant is intended for educational purposes and should not be used for self-diagnosis or medical decision-making. If you are concerned about your cardiovascular health or your family history of heart disease, the most effective step is to consult with a healthcare professional. A doctor can order clinical blood tests to measure your actual lipoprotein(a) levels, which provides a more direct assessment of your current health status than genetic testing alone. Never make changes to your medications or health regimen based on genetic reports without first discussing them with your clinician or pharmacist. They can help you interpret your results in the context of your overall health, including other risk factors like blood pressure, cholesterol levels, and lifestyle habits.
How common is this variant?
The minor allele frequency for rs10455874 is approximately 0.07 in European populations, while it is significantly rarer in African and Asian cohorts.
Frequently asked questions
Does having the rs10455874 variant mean I will get heart disease?
No, having this variant does not mean you will develop heart disease. It is a statistical risk factor, meaning it is associated with a higher likelihood of certain conditions, but many other genetic and environmental factors contribute to your overall health.
Can I change my Lp(a) levels through diet?
Lipoprotein(a) levels are primarily determined by your genetics and are generally resistant to changes in diet or exercise. You should discuss your specific lipid profile and any concerns about heart health with your doctor.
Should I get a genetic test for this variant?
Genetic testing for this variant is generally not required for routine medical care. If you are concerned about your cardiovascular risk, a standard blood test to measure your lipoprotein(a) levels is a more direct and clinically useful approach.
What is the difference between this variant and a diagnosis?
A genetic variant is a piece of information about your DNA, whereas a diagnosis is a clinical assessment made by a doctor based on symptoms, physical exams, and diagnostic tests. Genetic variants are only one part of the complex picture of human health.
Sources & further reading
Educational information only, last refreshed 9/25/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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This variant in the LPA gene elevates serum lipoprotein(a) levels, significantly increasing the risk of coronary atherosclerosis and aortic stenosis.
Variant in the LPA gene locus associated with circulating lipoprotein(a) levels and cardiovascular healthspan.
A splice-altering variant in LPA that lowers circulating lipoprotein(a) levels and is significantly associated with extended parental attained age and healthspan.
Intronic variant in LPA strongly associated with elevated circulating lipoprotein(a) levels and increased risk for coronary artery disease and aortic stenosis.
This variant is strongly associated with significantly elevated levels of Lipoprotein(a), a major independent risk factor for heart disease.
An LPA-locus variant identified as an independent genetic determinant of human healthspan and disease-free survival through modulated cardiovascular risk.