BRIP1 rs1064793626: Understanding This Genetic Variant
The rs1064793626 variant is a single nucleotide polymorphism located within the BRIP1 gene. It is documented in clinical databases as a common finding in population studies.
What each genotype means
Common genetic profile
This genotype represents the most frequently observed sequence at this position in the BRIP1 gene. Current population studies indicate this is a standard finding and does not inherently suggest an increased risk for clinical conditions. Please note that genetic associations are complex and should be discussed with a healthcare professional in the context of your overall health history.
This is the most common genotype observed across major global populations.
Common genetic profile
This genotype indicates you carry one copy of the variant allele at this position in the BRIP1 gene. Research identifies this as a common finding in population studies, and it is generally considered a normal variation. As with all genetic findings, this result should be interpreted by a clinician who can consider your personal and family health history.
This genotype is found at varying frequencies across different ancestral groups, consistent with its classification as a common variant.
Common genetic profile
This genotype indicates you carry two copies of the variant allele at this position in the BRIP1 gene. This is a documented finding in population databases and is considered a common genetic variation. This result does not constitute a diagnosis, and you should consult with a medical professional to understand how this fits into your broader health profile.
This genotype is observed in population studies, though its specific frequency varies depending on ancestral background.
What is rs1064793626?
The rs1064793626 variant is a specific genetic change, or single nucleotide polymorphism (SNP), located on chromosome 17. In the human genome, SNPs represent the most common type of genetic variation, occurring when a single building block of DNA—a nucleotide—is replaced by another. This particular variant is situated within the BRIP1 gene, which is located at the 17q23.2 cytogenetic position. Because the human genome is vast, researchers use rsIDs (reference SNP identification numbers) like rs1064793626 to precisely track and catalog these variations across different studies. This variant is cataloged in major genomic databases, including dbSNP and ClinVar, which serve as central repositories for researchers to share information about genetic findings observed in diverse populations.
The Role of the BRIP1 Gene
The BRIP1 gene, also known as FANCJ or BRCA1-interacting protein C-terminal helicase 1, provides instructions for making a protein that plays a critical role in DNA repair. Specifically, the BRIP1 protein is a helicase, an enzyme that helps unwind DNA strands, which is essential for the repair of double-strand breaks. This process is vital for maintaining genomic stability and is closely linked to the function of the BRCA1 protein, a well-known tumor suppressor. Because of its involvement in DNA repair, the BRIP1 gene is highly studied in the context of hereditary cancer syndromes. While some rare, pathogenic mutations in this gene are associated with an increased risk of certain cancers, such as ovarian cancer, it is important to distinguish these rare, high-impact mutations from common variants like rs1064793626.
Research and Evidence Strength
The evidence regarding the clinical significance of rs1064793626 is currently categorized as moderate. In the context of genomics, 'moderate' evidence often suggests that while the variant is frequently observed in population-wide sequencing projects, it has not been definitively linked to a specific disease or health outcome in the same way that rare, pathogenic mutations are. Many common variants identified in large-scale studies are considered neutral, meaning they do not significantly alter the function of the protein or contribute to disease risk. Researchers continue to investigate such variants to understand the full spectrum of human genetic diversity. It is essential to note that the presence of this variant in a genetic report does not constitute a medical diagnosis, and it should not be used to predict individual health outcomes without professional clinical interpretation.
Population Frequency
The rs1064793626 variant is classified as a common finding in population studies. This means that a significant portion of the general population carries this specific genetic change. Large-scale genomic databases, such as gnomAD and the 1000 Genomes Project, track the frequency of such variants across different ancestral groups. When a variant is described as 'common,' it typically indicates that it is a normal part of human genetic variation rather than a rare, disease-causing mutation. Because it is widespread, it is frequently encountered during routine genetic screening and sequencing efforts. Understanding the frequency of such variants helps scientists establish a baseline for what is considered 'normal' variation within the human population, which is a fundamental step in distinguishing common genetic traits from those that may have clinical relevance.
What You Can Do With This Information
Genetic information can be complex, and it is important to approach findings like rs1064793626 with a clear understanding of their limitations. Because this variant is a common, neutral finding, it generally does not require specific medical action or lifestyle changes. If you have received a report containing this variant, it is helpful to view it as a piece of your unique genetic profile rather than a health indicator. You cannot use this information to diagnose yourself or others, and it should not influence decisions regarding medical treatments or preventative care. If you have concerns about your genetic health or family history, the most appropriate step is to consult with a certified genetic counselor or a healthcare provider. They can help place your results in the context of your overall health and provide guidance based on established clinical standards.
How common is this variant?
This variant is documented as a common finding in population studies, appearing frequently across diverse ancestral groups.
Frequently asked questions
Is rs1064793626 a sign of cancer risk?
No, rs1064793626 is a common genetic variant and is not considered a marker for increased cancer risk. While the BRIP1 gene is involved in DNA repair, this specific variant is generally considered a neutral part of human genetic diversity.
Do I need to see a doctor if I have this variant?
Generally, no. Because this is a common, neutral variant, it does not typically require medical follow-up. However, if you have concerns about your family history or personal health, speaking with a healthcare provider is always a good idea.
What does 'common' mean in genetics?
In genetics, 'common' means that a variant is found in a significant percentage of the population. It indicates that the variation is a normal part of human genetic makeup rather than a rare, disease-causing mutation.
Can I use this information to change my diet or lifestyle?
No, this variant does not provide actionable information for diet or lifestyle changes. It is a neutral genetic finding that does not influence your health in a way that requires specific modifications.
Sources & further reading
Educational information only, last refreshed 10/9/2026. Not medical advice — these associations describe population statistics, not individual predictions.
Curious what your genotype is for rs1064793626?
Upload a raw DNA file from 23andMe, AncestryDNA, MyHeritage, or FamilyTreeDNA and see this variant — plus thousands more — interpreted in your full report.
Get my report — $29Related variants in BRIP1
This variant in the BRIP1 gene is associated with DNA repair mechanisms and cancer susceptibility.
This variant is located in the BRIP1 gene, which is linked to Fanconi anemia and breast cancer risk.
This variant is located in the BRIP1 gene, which is associated with DNA repair mechanisms and hereditary cancer predisposition syndromes.
This variant in the BRIP1 gene is documented in clinical databases and is relevant for assessing hereditary cancer predisposition.
This variant in the BRIP1 gene is associated with DNA damage repair mechanisms and is monitored for its potential link to cancer predisposition.