APOE rs1064793890: Understanding This Genetic Variant
The rs1064793890 variant is a specific genetic change located within the APOE gene, a region well-known for its role in Alzheimer's disease susceptibility. Current research is investigating how this and other variants in the APOE locus may influence individual risk profiles for neurodegenerative conditions.
What each genotype means
Typical APOE region profile
This genotype represents the most common configuration for this specific site in the APOE region. Current research indicates that while this variant is located in a gene region critical to Alzheimer's disease risk, the specific impact of this individual site is still being characterized by the scientific community. It is not considered a primary driver of disease risk compared to the well-established APOE ε2, ε3, and ε4 alleles.
This is the most frequent genotype observed across most global populations.
Variant APOE region profile
You carry one copy of the variant allele at this site. Research into this specific variant is ongoing, and its role in influencing Alzheimer's disease risk remains under investigation. Because this variant is located in the APOE region, it is of interest to researchers, but it does not currently change clinical risk assessments in the same way as established APOE genotypes.
This genotype is found at a low frequency in the general population.
Rare variant APOE profile
You carry two copies of the variant allele at this site. While this variant is located in the APOE region, which is highly significant for neurodegenerative health, the specific clinical implications of this rare genotype are not yet fully understood. Further research is required to determine if this genotype independently influences disease risk or interacts with other known APOE factors.
This genotype is rare and observed at a very low frequency across most ancestral groups.
What is the rs1064793890 Variant?
The rs1064793890 variant is a single nucleotide polymorphism (SNP) situated within the APOE gene. In genetics, a SNP represents a variation at a single position in the DNA sequence among individuals. This specific variant is part of the broader APOE genomic region, which has been extensively studied due to its critical influence on lipid metabolism and brain health. Because the APOE gene is highly polymorphic—meaning it contains many different variations—researchers track specific SNPs like rs1064793890 to understand how subtle changes in the genetic code might correlate with health outcomes. While many variants in this region are well-characterized, rs1064793890 is considered a newly annotated variant, meaning that scientific understanding of its specific functional impact is still evolving as more genomic data becomes available.
The Role of the APOE Gene
The APOE gene provides instructions for making a protein called apolipoprotein E. This protein is essential for the normal breakdown of fats (lipids) in the body and plays a major role in transporting cholesterol to cells. In the brain, APOE is the primary cholesterol carrier and is involved in the repair and maintenance of neurons. Because of these functions, the APOE gene is widely recognized as the most significant genetic modulator of sporadic Alzheimer's disease risk. Different versions of the APOE gene, such as the well-known ε2, ε3, and ε4 alleles, have distinct effects on how the brain manages amyloid-beta proteins and maintains the blood-brain barrier. Variations within this gene can alter the structure or expression of the protein, potentially impacting how effectively the brain protects itself against neurodegenerative processes.
Research and Evidence Strength
Current evidence linking rs1064793890 to specific health outcomes is categorized as moderate. In the context of complex diseases like Alzheimer's, genetic associations are often identified through large-scale genome-wide association studies (GWAS). These studies look for statistical correlations between specific variants and disease status across large populations. While the APOE region is a hotspot for Alzheimer's research, it is important to note that a statistical association does not imply a direct cause. Many factors, including other genetic modifiers, environmental exposures, and lifestyle, contribute to the development of neurodegenerative conditions. Because rs1064793890 is a newer entry in genetic catalogs, researchers are still working to determine if this variant has a functional effect on protein activity or if it is simply a marker inherited alongside other, more influential genetic changes.
Navigating Genetic Information
When encountering information about genetic variants, it is vital to remember that genetics is only one piece of a much larger health puzzle. APOE-related variants are susceptibility factors, not deterministic ones; they do not guarantee that an individual will or will not develop a condition. If you have received genetic testing results, it is best to discuss them with a qualified healthcare provider or a genetic counselor who can interpret the findings within the context of your personal and family medical history. Avoid making medical decisions based solely on individual SNP reports. If you are concerned about cognitive health or Alzheimer's risk, consult a clinician who can provide a comprehensive evaluation. Genetic information is a tool for research and clinical guidance, but it should never replace professional medical advice or diagnostic testing.
How common is this variant?
The rs1064793890 variant is documented as having a low population frequency, meaning it is relatively uncommon across most studied ancestral groups.
Frequently asked questions
Can this variant diagnose Alzheimer's disease?
No. APOE variants are susceptibility factors, not diagnostic tools. Alzheimer's disease is a complex condition influenced by many genetic and environmental factors, and no single SNP can determine a diagnosis.
Should I be worried if I have a rare APOE genotype?
Genetic variants are common, and having a specific genotype does not mean you will develop a disease. It is important to focus on overall health and consult with a doctor if you have concerns about your cognitive health.
Where can I find more information about my APOE status?
If you have undergone genetic testing, your report should provide context. For clinical interpretation, always speak with a genetic counselor or your primary care physician who can review your results alongside your medical history.
Is there a cure for Alzheimer's if I have a high-risk variant?
There is currently no cure for Alzheimer's disease. Research is focused on understanding the biology of the disease to develop better treatments, and knowing your genetic risk does not change the current standard of care.
Sources & further reading
Educational information only, last refreshed 10/8/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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Variant in the APOE/TOMM40 locus associated with late-onset Alzheimer's disease risk.
Downstream variant in the APOE region associated with lipid metabolism profiles and healthspan indicators.
Variant (c.497G>A, p.Arg166Gln) in the APOE gene known as Apolipoprotein E4 Christchurch, which has been shown in clinical case studies to confer resistance to familial Alzheimer's disease pathology.
Upstream regulatory variant influencing APOE transcription and plasma lipid modulation.
Defines the APOE ε2 allele, associated with lower LDL cholesterol and reduced risk of Alzheimer's disease.
Regulatory variant in the APOE promoter region modulating transcriptional activity and risk for late-onset neurodegeneration.