CDKN2B-AS1 rs1075413: what the research says
This variant is associated with an increased risk of coronary artery disease and related cardiovascular conditions.
What each genotype means
Baseline risk profile
This genotype represents the common version of the variant at this location. Research indicates that individuals with this genotype do not carry the specific genetic association linked to increased coronary artery disease risk found in the alternative version of this variant. Please note that cardiovascular health is influenced by many genetic and lifestyle factors, and this result should be viewed as only one small piece of your overall health picture.
Carried by approximately 30% of individuals of European ancestry.
Slightly elevated risk profile
This genotype includes one copy of the variant associated with a statistically higher risk of coronary artery disease in some studies. While this association has been observed in large populations, it does not mean you will develop heart disease, as many other factors contribute to cardiovascular health. You should continue to focus on heart-healthy habits and discuss your cardiovascular risk factors with your healthcare provider.
Carried by approximately 50% of individuals of European ancestry.
Increased risk profile
This genotype includes two copies of the variant associated with a statistically higher risk of coronary artery disease in various research studies. This association is part of a complex genetic landscape, and having this genotype does not guarantee the development of any condition. It is recommended that you maintain regular check-ups with your clinician to monitor your cardiovascular health and discuss appropriate screening or lifestyle adjustments.
Carried by approximately 20% of individuals of European ancestry.
Common in European populations (~45%)
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This variant is a well-established marker for coronary artery disease risk.
Non-coding RNA locus SNP associated with endometriosis development through altered regulation of cell cycle progression and local tissue remodeling.
Located in the non-coding CDKN2B-AS1 locus, this variant confers significant risk for normal-tension and primary open-angle glaucoma.
Chromosome 9p21 non-coding regulatory variant conferring increased predisposition to coronary artery disease, myocardial infarction, and intracranial aneurysm.
Non-coding regulatory variant on chromosome 9p21 altering cellular senescence pathways and microvascular endothelial reactivity traits.
A common regulatory variant at the CDKN2B-AS1 locus strongly associated with susceptibility to primary open-angle glaucoma and intraocular pressure regulation.