BDNF rs10767664: What Your Genotype Means
The rs10767664 variant is a single nucleotide polymorphism located within the BDNF gene. Research has linked this specific genetic marker to an increased risk of developing allergic rhinitis and allergic asthma in certain populations.
What each genotype means
Increased allergic risk profile
Research indicates that individuals with this genotype may have an increased risk of developing moderate-to-severe allergic rhinitis. This association is linked to the modulation of neurotrophin signaling, and studies have observed higher levels of BDNF protein and total IgE in the plasma of carriers. Please note that this evidence is primarily based on studies in specific East Asian populations and should be discussed with a healthcare provider in the context of your overall health.
This genotype is common, with the minor allele frequency for this variant reported between 0.40 and 0.50 in many populations.
Intermediate allergic risk profile
This genotype represents a heterozygous state for the BDNF variant associated with allergic airway inflammation. While research has highlighted the AA genotype as having a stronger association with allergic rhinitis risk, carriers of the AT genotype may show intermediate characteristics. As this is a complex trait influenced by many genetic and environmental factors, please consult with a clinician regarding any concerns about allergic symptoms.
This genotype is frequently observed in populations where the minor allele frequency is approximately 0.40 to 0.50.
Baseline allergic risk profile
This genotype represents the alternative homozygous state for the BDNF variant. Research into this specific variant typically identifies the A allele as the one associated with increased risk for allergic conditions like rhinitis and asthma, meaning this genotype does not carry that specific risk factor. Genetic associations are statistical in nature and do not determine health outcomes on their own.
This genotype is common, occurring in a significant portion of the population consistent with the reported minor allele frequencies.
Understanding the rs10767664 Variant
The rs10767664 variant is a single nucleotide polymorphism (SNP) found on chromosome 11 within the BDNF gene. In genetics, a SNP represents a variation at a single position in the DNA sequence among individuals. This specific variant acts as a tagging SNP, meaning it is often inherited alongside other nearby genetic changes. Because of this, researchers study it to understand how variations in this region might influence biological processes. While the variant itself is a small change in the genetic code, its location within the BDNF gene is significant because of the protein that this gene produces. Scientists use these markers to map out potential genetic predispositions to various health conditions, though the presence of a specific SNP does not guarantee that an individual will develop a particular trait or disease.
The Role of the BDNF Gene
The BDNF gene provides instructions for making a protein called brain-derived neurotrophic factor. This protein is a type of growth factor that plays a critical role in the survival, growth, and maintenance of neurons in the brain and nervous system. Beyond its well-known functions in the brain, BDNF is also involved in immune system regulation and inflammatory responses. Research suggests that BDNF may modulate neurotrophin signaling during allergic airway inflammation. When the BDNF gene functions differently due to genetic variations, it may alter the levels or activity of the BDNF protein. In the context of allergic conditions, these changes are thought to potentially influence how the body responds to allergens, which is why researchers have investigated its connection to conditions like allergic rhinitis and asthma.
Research Associations and Evidence Strength
The evidence linking rs10767664 to allergic conditions is considered limited and primarily observed in specific ethnic groups. Studies, particularly in Singaporean and Shandong Chinese populations, have reported that individuals carrying the A allele of rs10767664 show an increased risk of moderate-to-severe allergic rhinitis. Some research has also explored its association with allergic asthma, suggesting that the variant may influence plasma levels of BDNF and total IgE, a marker often elevated in allergic responses. However, it is important to note that genetic associations can be complex and may not be consistent across all global populations. The findings are often specific to the cohorts studied, and the biological mechanisms linking this SNP to clinical outcomes are still being explored. As with many complex traits, the risk is likely influenced by a combination of multiple genetic factors and environmental exposures.
Population Frequency
The rs10767664 variant is relatively common, with a minor allele frequency typically ranging between 0.40 and 0.50 in both East Asian and European populations. This means that a significant portion of the population carries at least one copy of the variant allele. Because the frequency is high, it is considered a common genetic variation rather than a rare mutation. Understanding these frequencies helps researchers determine if a specific association is statistically significant within a given group. However, high frequency also implies that the variant is a normal part of human genetic diversity, and its presence alone is not a diagnostic indicator of disease.
What This Information Means for You
If you have learned your genotype for rs10767664, it is important to view this information in the proper context. Genetic variants are only one piece of a much larger puzzle that includes your environment, lifestyle, and other genetic factors. Having a genotype associated with a higher risk does not mean you will develop a condition, nor does having a 'lower risk' genotype guarantee protection. This information is for educational purposes and should not be used for medical diagnosis or to make decisions about your health. If you have concerns about allergies, asthma, or any other health condition, please consult with a qualified healthcare professional. They can provide personalized advice based on your medical history and clinical symptoms. Never change or stop any medication based on genetic test results without first discussing it with your doctor or pharmacist.
How common is this variant?
The minor allele frequency for rs10767664 is approximately 0.40–0.50 in both East Asian and European populations.
Frequently asked questions
Does having the A allele mean I will get asthma?
No. Genetic associations are statistical, not deterministic. Many people with the A allele do not have asthma, and many people with asthma do not carry this specific variant.
Can I use this SNP to diagnose an allergy?
No. Genetic testing for this SNP is not a diagnostic tool for allergies. Allergies are diagnosed by clinicians based on physical exams, medical history, and allergy testing.
Is this variant only found in Asian populations?
No. While the association was notably studied in Chinese populations, the variant is also found in European populations at similar frequencies.
Should I change my allergy medication based on this result?
No. You should never change your medication based on genetic information without consulting your doctor or pharmacist. They are the only ones who can safely manage your treatment plan.
Sources & further reading
Educational information only, last refreshed 10/15/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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