LHB rs10775: Understanding This Genetic Variant
The rs10775 variant is a single-nucleotide polymorphism located in the 3-prime untranslated region (3-prime UTR) of the LHB gene. This gene encodes the beta subunit of luteinizing hormone, which plays a critical role in reproductive health by regulating ovulation and steroid production.
What each genotype means
Typical luteinizing hormone regulation
You carry two copies of the common C allele in the 3-prime untranslated region of the LHB gene. Published research suggests this baseline genotype is associated with standard transcriptional regulation of luteinizing hormone subunit beta and typical luteal phase steroidogenesis. Because available evidence for this variant is limited and observational, it does not imply any diagnosis or clinical endocrine abnormality.
Carried by approximately 80% to 85% of individuals of European ancestry and roughly 75% to 80% of individuals of African ancestry.
Altered luteal steroidogenesis profile
You carry one copy of the T allele for the rs10775 variant in the LHB gene. Some exploratory studies indicate that carrying a minor allele in this regulatory region may modestly alter luteinizing hormone expression dynamics and luteal phase steroid hormone production. However, evidence remains limited and findings are not diagnostic of reproductive dysfunction or clinical hormone deficiency.
Carried by approximately 15% to 16% of individuals of European ancestry and about 20% to 22% of individuals of African ancestry.
Altered luteal steroidogenesis profile
You carry two copies of the less common T allele in the LHB 3-prime untranslated region. Research indicates this genotype may influence transcriptional regulation of the beta subunit of luteinizing hormone, with possible minor effects on downstream steroidogenesis. Given the limited strength of published evidence, carrying this genotype represents a statistical physiological variation rather than a medical condition.
Carried by fewer than 1% to 2% of individuals in European and African populations.
What is the rs10775 Variant?
The rs10775 variant is a specific change in the DNA sequence located within the LHB gene on chromosome 19. Specifically, it sits in the 3-prime untranslated region (3-prime UTR). While the coding regions of a gene provide the direct instructions for building a protein, the 3-prime UTR is a segment of messenger RNA that follows the coding sequence. This region is essential for regulating gene expression, including the stability of the mRNA and how efficiently it is translated into a functional protein. By residing in this regulatory area, rs10775 is hypothesized to influence the transcriptional regulation of the luteinizing hormone beta subunit, potentially altering the levels of the hormone produced by the pituitary gland.
The Role of the LHB Gene
The LHB gene provides instructions for creating the beta subunit of luteinizing hormone (LH). Luteinizing hormone is a glycoprotein hormone secreted by the pituitary gland that is vital for the reproductive system in both men and women. In females, it triggers ovulation and supports the production of progesterone in the ovaries. In males, it stimulates the Leydig cells in the testes to produce testosterone, which is necessary for spermatogenesis. Because the LHB gene is so central to these hormonal pathways, its proper function is essential for normal reproductive development and fertility. Rare, severe mutations in this gene have been linked to conditions like hypogonadism, but common variants like rs10775 are generally studied for their more subtle effects on hormonal balance.
Research and Evidence Strength
Current research into rs10775 is categorized as having limited evidence regarding its clinical impact. While the variant is associated with potential changes in luteal phase steroidogenesis—the process by which the body produces hormones during the second half of the menstrual cycle—the functional consequences of this specific SNP are not fully understood. Most studies on LHB variants focus on rare, pathogenic mutations that cause significant hormonal deficiencies. In contrast, rs10775 is a common polymorphism, and its influence on overall health or fertility remains a subject of ongoing investigation. Because the evidence is limited, it is not currently used as a diagnostic tool or a definitive predictor of reproductive health outcomes in clinical settings.
What You Can Do With This Information
Genetic information regarding variants like rs10775 is primarily educational and should not be used to make medical decisions. Because the link between this variant and specific health outcomes is not well-established, it cannot be used to diagnose conditions or predict fertility. If you have concerns about your reproductive health, hormone levels, or fertility, it is important to consult with a qualified healthcare provider or a reproductive endocrinologist. They can perform appropriate clinical testing, such as blood hormone panels, which provide a much more accurate picture of your health than genetic data alone. Never use genetic reports to alter medications or ignore symptoms; always discuss your health history and any genetic findings with a medical professional who can provide personalized guidance.
How common is this variant?
The minor allele frequency for rs10775 is approximately 0.08 in European populations and 0.12 in African populations, indicating it is a relatively common variant.
Frequently asked questions
Is rs10775 a cause of infertility?
No. While the LHB gene is involved in reproductive processes, rs10775 is a common variant with limited evidence linking it to clinical infertility. Infertility is a complex condition with many causes, and this SNP is not considered a primary diagnostic marker.
Should I be worried if I have the 'variant' genotype?
There is no reason for concern. Most genetic variants, including rs10775, are simply part of normal human diversity and do not cause disease. This variant is not classified as a pathogenic mutation.
Can this variant affect my testosterone or progesterone levels?
Some research suggests it may influence transcriptional regulation, but there is no strong evidence that it causes clinically significant changes in hormone levels. If you are concerned about your hormone levels, please consult a doctor for a blood test.
Where can I find more information about LHB?
You can find reliable information on the LHB gene through the NCBI Gene database or the OMIM (Online Mendelian Inheritance in Man) website. These resources provide detailed summaries of gene function and known clinical associations.
Sources & further reading
Educational information only, last refreshed 10/17/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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Inactivating missense mutation in the luteinizing hormone beta subunit resulting in hypogonadism and impaired gonadal steroidogenesis.
Pathogenic variant in the luteinizing hormone beta subunit gene associated with hypogonadotropic hypogonadism and infertility due to selective LH deficiency.