rs10786156: Understanding the Genetic Link to Cluster Headache
The rs10786156 variant is a genetic marker located on chromosome 10 that has been identified through genome-wide association studies (GWAS). It is recognized as a significant index variant associated with an increased susceptibility to cluster headache.
What each genotype means
Typical risk profile
This genotype represents the common state at this location on chromosome 10. Research indicates that individuals carrying the C allele at this position have a statistically higher susceptibility to cluster headache compared to those without it. This association is based on population-level data and does not predict individual health outcomes.
The C allele is the index allele associated with increased risk in genome-wide association studies of cluster headache.
Slightly elevated risk
Carrying one copy of the C allele is associated with a modest increase in the odds ratio for developing cluster headache. This finding is derived from large-scale genetic studies comparing individuals with cluster headache to healthy controls. Please consult with a healthcare professional if you have concerns regarding neurological symptoms or headache patterns.
This heterozygous genotype is observed in populations where the C allele contributes to the genetic architecture of cluster headache susceptibility.
Baseline risk profile
This genotype does not carry the C allele identified as a risk factor for cluster headache in recent genome-wide association studies. While this specific genetic marker is not associated with increased risk for you, cluster headache is a complex condition influenced by many genetic and environmental factors. This information is for educational purposes and should not be used to rule out any medical condition.
The T allele is the non-risk allele at this locus, and the TT genotype is found in the general population.
What is the rs10786156 Variant?
The rs10786156 variant is a single nucleotide polymorphism (SNP) located in an intergenic region on chromosome 10. In genetics, an intergenic region refers to the stretches of DNA located between genes. While these regions do not code for proteins directly, they often contain regulatory elements that can influence how nearby genes are expressed. Researchers identify such variants using genome-wide association studies (GWAS), which scan the entire genome to find statistical links between specific DNA markers and complex traits or diseases. Because rs10786156 is an index variant, it serves as a primary signpost for a specific genomic region that shows a strong statistical correlation with the occurrence of cluster headache in the populations studied.
Research and Cluster Headache Association
Scientific research, including large-scale GWAS, has identified rs10786156 as a risk locus for cluster headache. Studies have reported that individuals carrying the risk allele (the C allele) show an increased odds ratio for developing this condition compared to those who do not. The evidence for this association is considered moderate to strong within the context of current genetic research, as it has been highlighted in peer-reviewed literature investigating the genetic architecture of primary headache disorders. It is important to note that cluster headache is a complex, multifactorial condition. This means that while genetic variants like rs10786156 contribute to an individual's overall risk, they are not the sole cause of the disorder. Environmental factors and other genetic influences also play significant roles in the development of the condition.
Understanding Your Results
If you encounter information about your genotype for rs10786156, it is essential to understand that this is a statistical association, not a medical diagnosis. Having a specific genotype does not guarantee that an individual will develop cluster headache, nor does the absence of the risk allele provide immunity. Genetic testing for such variants is primarily used in research settings to better understand the biological pathways involved in disease. If you are experiencing symptoms such as severe, recurring headaches, you should consult a healthcare professional or a neurologist. They can provide a clinical evaluation, which is the only way to accurately diagnose a headache disorder. Never use genetic data to make decisions about your health or to attempt self-diagnosis.
How common is this variant?
The frequency of the rs10786156 variant varies across different ancestral populations. Current research primarily highlights its association with cluster headache risk in European-ancestry cohorts.
Frequently asked questions
Does having the rs10786156 variant mean I will get cluster headaches?
No. Genetic variants like rs10786156 only indicate a statistical increase in risk. Many people with the risk genotype never develop the condition, and many people without it do.
Is rs10786156 a diagnostic test for cluster headache?
No. Cluster headache is diagnosed by a physician based on clinical symptoms and medical history. Genetic markers are currently used for research purposes to understand the disease, not for clinical diagnosis.
What should I do if I know my genotype for this variant?
You should treat this information as a general insight into your genetic makeup. If you have concerns about your health or are experiencing symptoms, please consult a doctor.
Are there other genes involved in cluster headache?
Yes. Cluster headache is a complex disorder influenced by multiple genetic loci and environmental factors. Research is ongoing to identify the full range of genetic contributors.
Sources & further reading
Educational information only, last refreshed 11/1/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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