CYP19A1 rs10835636: What Your Genotype Means
The rs10835636 variant is a common genetic change located within the CYP19A1 gene. Research suggests this variant is associated with variations in circulating estradiol levels and the timing of natural menopause in women.
What each genotype means
Typical CYP19A1 regulatory profile
This genotype represents one of the common configurations for this regulatory region of the CYP19A1 gene. Research indicates that variants in this gene are associated with variations in circulating estradiol levels in postmenopausal women, though these differences are generally considered to be within a normal physiological range.
This genotype is common globally, reflecting the high frequency of the A allele in many populations.
Typical CYP19A1 regulatory profile
Carrying one copy of each allele is a common configuration for this regulatory variant. Studies suggest that genetic variation in CYP19A1 can influence estrogen biosynthesis, but these associations are complex and influenced by many other genetic and environmental factors.
This heterozygous genotype is frequently observed across diverse ancestral groups.
Typical CYP19A1 regulatory profile
This genotype is a common variant configuration for the CYP19A1 gene. While research has linked variants in this gene to differences in endogenous estrogen levels, these findings are statistical associations observed in large populations and do not indicate a clinical condition or specific health outcome for an individual.
This genotype is found at a significant frequency in global populations, consistent with the common nature of this variant.
Understanding the rs10835636 Variant
The rs10835636 variant is a single nucleotide polymorphism (SNP) situated within the CYP19A1 gene. In genetics, a SNP represents a variation at a single position in the DNA sequence among individuals. This specific variant is classified as an intronic regulatory variant, meaning it resides in a non-coding region of the gene known as an intron. While introns do not provide the direct instructions for building proteins, they often contain regulatory elements that act like switches, controlling when, where, and how much of a gene's product is created. By influencing these regulatory processes, rs10835636 may affect the overall activity of the gene, potentially leading to subtle differences in biological outcomes between individuals who carry different versions of this DNA sequence.
The Role of the CYP19A1 Gene
The CYP19A1 gene provides instructions for producing an enzyme called aromatase. This enzyme is a critical component of the cytochrome P450 family, which is responsible for various metabolic processes in the body. Aromatase is primarily known for its role in estrogen biosynthesis; it catalyzes the conversion of androgens, such as androstenedione and testosterone, into estrogens, specifically estrone and estradiol. This process is essential for reproductive health, as these hormones regulate the female reproductive system and influence various physiological functions in both men and women. Because aromatase is the final step in the production of active estrogens, any factor that alters the expression or efficiency of the CYP19A1 gene can have downstream effects on the balance of sex hormones circulating in the bloodstream.
Research Associations and Evidence
Scientific studies have investigated the relationship between CYP19A1 variants and various health-related traits. The rs10835636 variant has been identified in research as being associated with circulating estradiol levels and the timing of natural menopause. The evidence for these associations is generally considered moderate, as genetic studies often observe complex interactions between multiple genes and environmental factors. While some studies suggest that specific genotypes may correlate with earlier or later onset of menopause, it is important to recognize that menopause is a multifactorial process influenced by genetics, lifestyle, and overall health. Because these associations are based on statistical correlations across large populations, they do not necessarily predict an individual's specific reproductive timeline or hormone levels. Further research is ongoing to clarify the precise biological mechanisms by which this intronic variant influences aromatase activity.
Population Frequency and Interpretation
The rs10835636 variant is considered a common genetic marker, with a global minor allele frequency (MAF) of approximately 0.35 according to data from the 1000 Genomes Project. This means that the variant is widely distributed across diverse human populations. When interpreting genetic information, it is crucial to understand that common variants often have small individual effects. Having a particular genotype does not determine a specific health outcome but rather contributes to the natural variation seen within the human population. Because genetic associations can vary significantly based on ancestral background, findings from one group may not always apply to another. Genetic data should be viewed as one piece of a much larger puzzle that includes personal health history and environmental factors.
Navigating Genetic Information
Accessing information about your genetic variants can be an educational experience, but it is important to maintain a balanced perspective. Genetic associations, such as those linked to rs10835636, are statistical observations made at the population level and are not diagnostic tools for individuals. You cannot use this information to predict your personal reproductive health or hormone status with certainty. If you have concerns about your hormone levels, reproductive health, or the timing of menopause, the most appropriate step is to consult with a qualified healthcare provider. They can evaluate your specific clinical history and provide guidance based on established medical standards. Never use genetic data to make decisions about medications or treatments; always discuss any health-related questions or potential interventions with your clinician or pharmacist.
How common is this variant?
The rs10835636 variant is common globally, with a minor allele frequency of approximately 0.35 in the 1000 Genomes Project dataset.
Frequently asked questions
What does the CYP19A1 gene do?
The CYP19A1 gene encodes the aromatase enzyme, which is responsible for converting androgens like testosterone into estrogens like estradiol. This process is vital for maintaining hormonal balance in the body.
Can this variant predict when I will reach menopause?
No, this variant cannot predict your specific age of menopause. While it is statistically associated with the timing of natural menopause in population studies, many other genetic and environmental factors play a much larger role.
Is rs10835636 a disease-causing mutation?
No, rs10835636 is a common genetic variant, not a disease-causing mutation. It is a normal variation in the human genome that may contribute to natural differences in hormone levels.
Should I be worried about my genotype for this SNP?
There is no reason to be worried about your genotype for this SNP. It is a common variation, and having one genotype over another does not indicate a health problem or a medical condition.
Sources & further reading
Educational information only, last refreshed 10/16/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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This variant in the aromatase gene is associated with circulating estrogen levels and influences the timing of natural menopause and cardiovascular risk profiles in postmenopausal women.
This regulatory variant in the aromatase gene is associated with circulating estradiol levels and the timing of natural menopause.
Pathogenic variant causing aromatase deficiency characterized by female pseudohermaphroditism, maternal virilization during pregnancy, and absent pubertal development.
Intronic variant in the CYP19A1 gene associated with circulating estradiol and follicle-stimulating hormone (FSH) levels in men.
This variant in the aromatase gene is associated with variations in sex hormone levels and potential risk modulation for hormone-dependent reproductive cancers.
Affects aromatase activity, influencing efficacy and toxicity in hormone-sensitive cancer treatments.