OR52I1 rs10836331: Understanding This Brain-Associated Variant
The genetic variant rs10836331 is a single nucleotide polymorphism located within the OR52I1 gene. Genome-wide association studies have identified a statistical link between this variant and various brain-related traits.
What each genotype means
Typical brain trait association
This genotype is associated with specific brain-related traits identified in large-scale genome-wide association studies. Because this variant is located in a region linked to complex neurological traits, the exact functional impact remains a subject of ongoing research. Please note that genetic associations are statistical in nature and do not determine individual health outcomes.
This genotype is common in many global populations, though exact frequencies vary significantly by ancestral background.
Typical brain trait association
Carrying one copy of each allele is associated with the same brain-related traits observed in genome-wide studies of this variant. Current research indicates that this variant may play a role in neurological trait variation, but the biological mechanism is not yet fully understood. These findings represent population-level trends rather than individual diagnostic information.
This heterozygous genotype is frequently observed across diverse populations, representing a common variation in the human genome.
Typical brain trait association
This genotype is associated with brain-related traits as reported in genome-wide association studies. While this variant is cataloged for its link to neurological traits, the evidence is considered moderate and the specific biological influence on brain function is still being investigated. Genetic data should be interpreted as one of many factors contributing to human trait diversity.
This genotype is found at varying frequencies globally, with prevalence patterns often differing between continental populations.
What is rs10836331?
The variant rs10836331 is a specific change in the DNA sequence, known as a single nucleotide polymorphism (SNP), located within the human genome. In the context of genetic research, SNPs are the most common type of genetic variation among people. Each SNP represents a difference in a single DNA building block, called a nucleotide. The rs10836331 variant is situated within the OR52I1 gene, which stands for olfactory receptor family 52 subfamily I member 1. Researchers track these variants using an rsID (reference SNP cluster ID) to ensure consistency across global scientific databases. By studying where these variants sit in the genome, scientists can begin to map out how specific DNA sequences might correlate with physical or neurological characteristics observed in large populations.
The Role of the OR52I1 Gene
The OR52I1 gene encodes a protein that belongs to the olfactory receptor family. Olfactory receptors are primarily known for their role in the nose, where they interact with odorant molecules to initiate the biological signals that lead to the perception of smell. While these receptors are essential for olfaction, research has also shown that OR52I1 is expressed in other tissues, including the brain and the male reproductive system. The presence of olfactory receptors in non-olfactory tissues is a subject of ongoing scientific interest, as these proteins may perform functions beyond simple scent detection. Understanding the expression patterns of OR52I1 helps researchers investigate why variants within this gene might show statistical associations with traits that appear unrelated to the sense of smell.
Research and Evidence Strength
The association between rs10836331 and brain-related traits has been identified through genome-wide association studies (GWAS). These studies scan the genomes of thousands of individuals to find statistical correlations between specific variants and observed traits or conditions. According to data curated by the GWAS Catalog, rs10836331 has been linked to brain attributes. It is important to note that the evidence strength for this association is currently considered moderate. A statistical association in a GWAS does not necessarily imply a direct cause-and-effect relationship; rather, it suggests that the variant is located in a region of the genome that may influence the trait in question. Further functional studies are often required to determine the biological mechanism, if any, by which this variant might influence brain-related characteristics.
Interpreting Your Genetic Information
When you encounter information about genetic variants like rs10836331, it is helpful to understand what this data means for you personally. Genetic associations are typically based on population-level statistics, meaning they describe trends across large groups of people rather than predicting individual outcomes. Because the evidence for this specific variant is moderate and based on complex GWAS data, it cannot be used to diagnose any condition or predict specific brain-related health outcomes. If you have questions about your genetic results or how they relate to your health, the most appropriate step is to consult with a qualified healthcare professional or a genetic counselor. They can provide context based on your personal and family medical history, ensuring that you receive accurate information tailored to your specific needs.
How common is this variant?
The frequency of the rs10836331 alleles varies across different ancestral populations. Detailed frequency data for this variant is available through public resources like dbSNP and gnomAD.
Frequently asked questions
Is rs10836331 associated with a specific disease?
Current research identifies rs10836331 as being associated with brain-related traits in genome-wide association studies. It is not currently linked to a specific disease diagnosis.
Can I use this variant to predict my brain health?
No, this variant cannot be used to predict individual brain health. Genetic associations are statistical findings from large populations and do not provide individual medical predictions.
What does the OR52I1 gene do?
The OR52I1 gene encodes an olfactory receptor protein. While primarily involved in the sense of smell, it is also expressed in other tissues, including the brain.
Where can I find more information about this SNP?
You can find more information about rs10836331 by searching the NCBI dbSNP database or the GWAS Catalog. These resources provide curated data on genetic variants and their reported associations.
Sources & further reading
Educational information only, last refreshed 10/2/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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This variant is identified in the GWAS Catalog as having associations with specific brain-related attributes.
A synonymous variant in the OR52I1 gene identified as having clinical significance in ClinVar.
A missense variant in the OR52I1 gene annotated as likely benign in ClinVar.
A missense variant in the OR52I1 gene annotated as likely benign in ClinVar.