PAPSS2 rs10887741: What Your Genotype Means
The rs10887741 variant is a common single nucleotide polymorphism located within the PAPSS2 gene. Research has investigated this variant for its potential associations with variations in leisure-time physical activity and cardiorespiratory fitness responses.
What each genotype means
Baseline exercise association
This genotype represents the non-risk allele configuration identified in studies of exercise behavior. Research suggests that individuals with this genotype may have different baseline tendencies regarding leisure-time physical activity compared to those carrying the T allele. These findings are based on statistical associations in population studies and do not determine individual exercise capacity or outcomes.
This is a common genotype found in a significant portion of the global population.
Intermediate exercise association
This heterozygous genotype includes one copy of the T allele, which has been statistically associated with variations in leisure-time physical activity levels. Research indicates that this variant may play a role in how individuals respond to lifestyle interventions regarding physical activity and cardiorespiratory fitness. These associations are based on population-level data and should not be used to predict personal fitness outcomes.
This is a common genotype observed across diverse ancestral populations.
Increased exercise association
This genotype contains two copies of the T allele, which has been identified in genome-wide association studies as a risk allele linked to variations in leisure-time exercise behavior. While this variant is studied for its potential role in moderating responses to lifestyle interventions, it is only one of many factors influencing physical activity. These results reflect population-level trends and are not a measure of an individual's potential for physical fitness.
This genotype is common, with the T allele appearing in approximately one-third of individuals in many studied populations.
Understanding the rs10887741 Variant
The rs10887741 variant is a single nucleotide polymorphism (SNP) situated on chromosome 10. In the context of human genetics, a SNP represents a variation at a single position in the DNA sequence among individuals. This specific variant is located within the PAPSS2 gene, which provides instructions for making an enzyme called 3'-phosphoadenosine 5'-phosphosulfate synthetase 2. This enzyme plays a critical role in the process of sulfation, a chemical modification necessary for the proper function of various molecules in the body, including those involved in cartilage development and hormone regulation. Because this variant is common in the general population, it has been a subject of interest in genome-wide association studies (GWAS) aimed at identifying genetic factors that might influence complex behavioral and physiological traits, such as how individuals engage in physical activity or respond to exercise interventions.
The Role of the PAPSS2 Gene
The PAPSS2 gene is essential for the production of PAPS, the universal sulfate donor in the cell. Sulfation is a vital biological process that helps activate or deactivate various compounds, including neurotransmitters, hormones, and structural proteins in the extracellular matrix. While rare, severe mutations in the PAPSS2 gene are known to cause a form of spondyloepimetaphyseal dysplasia, a skeletal disorder characterized by abnormal bone growth and development. However, the rs10887741 variant is a common polymorphism, meaning it is a standard variation found in healthy individuals rather than a disease-causing mutation. Scientists study such common variants to understand how subtle differences in gene expression or enzyme activity might contribute to natural variation in human health and fitness. It is important to distinguish these common, small-effect variants from the rare, high-impact mutations that lead to specific clinical genetic conditions.
Research Associations and Evidence Strength
The evidence linking rs10887741 to physical activity and fitness is considered moderate and complex. Early research identified this SNP as having a statistical association with leisure-time exercise behavior. Subsequent studies have attempted to determine if this variant, often in combination with others, influences how individuals respond to structured lifestyle interventions, such as exercise programs aimed at improving cardiorespiratory fitness. Findings have been mixed; some analyses suggest that the influence of this genetic marker may be moderated by other factors, such as age. For instance, some research has indicated that the association between polygenic scores—which include rs10887741—and physical activity phenotypes might be more pronounced in older age groups. Because these associations are statistical in nature and often show small effect sizes, they do not provide a definitive prediction of an individual's athletic potential or their specific response to any given exercise regimen.
Interpreting Your Genetic Information
It is important to understand that genetic variants like rs10887741 provide only a tiny fraction of the information regarding an individual's physical fitness or activity levels. Lifestyle, environment, socioeconomic factors, and thousands of other genetic variants all play significant roles in shaping these complex traits. You cannot use this information to diagnose a medical condition, predict your future athletic performance, or determine the effectiveness of a specific workout plan. Genetic associations identified in research studies are meant to help scientists understand the biological pathways underlying human traits, not to serve as a guide for personal health decisions. If you are interested in improving your physical fitness or starting a new exercise program, the most effective approach is to consult with a qualified fitness professional or healthcare provider who can offer personalized guidance based on your current health status and goals.
How common is this variant?
The rs10887741 variant is considered common, with a global minor allele frequency reported at approximately 0.337 in major population databases.
Frequently asked questions
Does my genotype for rs10887741 determine if I am athletic?
No. Athletic ability is a complex trait influenced by a vast combination of genetic, environmental, and lifestyle factors. A single SNP like rs10887741 has a negligible impact on overall physical performance.
Can I use this SNP to choose the best exercise program for me?
No. There is no scientific evidence to support using this genetic variant to tailor exercise programs. You should focus on evidence-based training principles and consult with a fitness professional.
Is rs10887741 related to the PAPSS2-type skeletal dysplasia?
No. The rare, severe mutations that cause PAPSS2-type skeletal dysplasia are distinct from the common rs10887741 polymorphism. This SNP is a normal variation found in the general population.
Why do research results for this SNP seem inconsistent?
Genetic association studies often show mixed results because complex traits are influenced by many genes and environmental factors. Differences in study design, participant age, and population ancestry can also lead to varying findings.
Sources & further reading
Educational information only, last refreshed 10/11/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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