ANGPTL3 rs10889353: What Your Genotype Means
The rs10889353 variant is a single-nucleotide polymorphism located within the ANGPTL3 gene. It is currently being investigated by researchers for its potential role in modulating LDL cholesterol levels in response to specific dietary patterns.
What each genotype means
Typical lipid association
This genotype represents the major allele combination for this variant. Research indicates that this variant is associated with variations in total cholesterol and triglyceride levels, though the clinical significance of this specific genotype remains limited and requires further study. Please discuss your lipid profile and any dietary concerns with your healthcare provider.
This is the most common genotype observed in many populations, though exact frequencies vary significantly by ancestry.
Varied lipid association
Carrying one copy of the minor allele (C) has been associated in some studies with differences in total cholesterol and triglyceride concentrations. The evidence for this association is limited, and it is not considered a diagnostic marker for lipid disorders. You should consult with a clinician or pharmacist to interpret your specific lipid panel results in the context of your overall health.
This heterozygous genotype is found at moderate frequencies across various global populations.
Minor allele association
This genotype represents the homozygous minor allele state, which has been linked in some research to variations in blood lipid levels, specifically total cholesterol and triglycerides. Because the evidence strength for this variant is limited, this result should not be used to predict specific health outcomes. Always review your blood work and metabolic health with a qualified medical professional.
This genotype is less common than the major allele homozygote and shows variable frequency depending on ancestral background.
Understanding the rs10889353 Variant
The rs10889353 variant is a specific genetic change, or single-nucleotide polymorphism (SNP), located within the ANGPTL3 gene. In genomics, a SNP represents a variation at a single position in the DNA sequence among individuals. This particular variant is categorized within the field of nutrigenomics, which examines how genetic variations interact with dietary intake to influence health outcomes. While many variants in the ANGPTL3 gene have been studied for their impact on blood lipid levels, rs10889353 is specifically noted in research for its potential to modify how an individual's body responds to different dietary compositions, such as the Portfolio Diet. Because this is a complex interaction, the specific biological mechanism by which this single change might influence cholesterol levels remains a subject of ongoing scientific inquiry rather than a settled clinical fact.
The Role of the ANGPTL3 Gene
The ANGPTL3 gene provides instructions for producing the angiopoietin-like 3 protein, which is primarily secreted by the liver. This protein acts as a key regulator of lipid metabolism by inhibiting enzymes such as lipoprotein lipase and endothelial lipase. By controlling these enzymes, the ANGPTL3 protein influences the levels of triglycerides, LDL cholesterol, and HDL cholesterol circulating in the blood. Because of its central role in lipid processing, the ANGPTL3 gene has become a significant target for both genetic research and therapeutic development. While rare loss-of-function variants in this gene are well-documented to cause significant reductions in plasma lipid levels, common variants like rs10889353 are studied to understand the more subtle, everyday variations in how different people process fats and cholesterol based on their unique genetic makeup and dietary habits.
Research and Evidence Strength
The evidence linking rs10889353 to specific health outcomes is currently classified as limited. Scientific studies, such as those conducted within the Toronto Nutrigenomics and Health Study, have utilized candidate gene approaches to examine whether this variant modifies the association between dietary patterns and LDL cholesterol concentrations. While some research has observed correlations between dietary scores and lipid levels, the interaction between specific genetic variants like rs10889353 and these diets is complex and not yet fully understood. It is important to distinguish between the well-established effects of rare, severe mutations in ANGPTL3 and the much smaller, often variable effects of common SNPs. Current research is still working to determine if this variant has a consistent, measurable impact across diverse populations or if its effects are highly dependent on other genetic and environmental factors.
Interpreting Your Genetic Information
When considering information about variants like rs10889353, it is essential to understand that genetic data is not a medical diagnosis. The associations observed in research studies are statistical in nature and describe trends across large groups of people, which may not apply to any single individual. You cannot use this information to predict your personal cholesterol levels or to make decisions about your diet or medication without professional guidance. If you are concerned about your lipid profile or cardiovascular health, you should consult with a healthcare provider or a registered dietitian. They can provide personalized advice based on your clinical history, blood work, and overall health status. Always discuss any changes to your diet or potential medication dosing with your clinician or pharmacist, as they are the only ones qualified to interpret your health data in a clinical context.
How common is this variant?
The frequency of the rs10889353 variant is variable across different ancestral populations, and specific allele frequencies should be checked in databases like gnomAD for precise regional data.
Frequently asked questions
What does the ANGPTL3 gene do?
The ANGPTL3 gene produces a protein that helps regulate how the body processes fats and cholesterol. It works by inhibiting enzymes that break down lipids in the blood.
Can I use this SNP to predict my cholesterol levels?
No. This variant is associated with small, statistical trends in research studies and cannot be used to predict your individual cholesterol levels or health outcomes.
Is rs10889353 a cause of high cholesterol?
There is no evidence that this common variant causes high cholesterol. It is being studied for its potential to influence how diet might affect lipid levels, but the evidence is currently limited.
Should I change my diet based on my rs10889353 genotype?
You should not change your diet based on this genetic information. Always consult with a healthcare provider or a registered dietitian before making significant changes to your nutrition plan.
Sources & further reading
Educational information only, last refreshed 10/28/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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