LOC105377508 rs1104897: What Your Genotype Means
rs1104897 is a common single nucleotide polymorphism mapped within or adjacent to the non-coding RNA locus LOC105377508. In genome-wide association studies, this variant has been examined in relation to human physiological characteristics and anthropometric measurements. However, overall scientific evidence supporting a direct, causative biological effect remains limited.
What each genotype means
| Genotype | What the research suggests | Reading |
|---|---|---|
| CC | Homozygous for the C allele at rs1104897. In population studies, this common genotype represents a standard background baseline for evaluated anthropometric and physiological traits without indicating any clinical risk. | Informational |
| CT | Heterozygous carrier of one C allele and one T allele at rs1104897. This common combination reflects standard population-level genetic diversity and shows only minor statistical associations in complex trait research. | Informational |
| TT | Homozygous for the T allele at rs1104897. This genotype is commonly observed across global populations and exhibits modest associations with physiological measurements in exploratory genome-wide studies without diagnostic significance. | Informational |
Genomic Context and the LOC105377508 Locus
The genetic variant rs1104897 is a single nucleotide polymorphism positioned in a non-coding region of the human genome documented under the locus symbol LOC105377508. Rather than residing within an established, classical protein-coding gene, LOC105377508 denotes an uncharacterized, non-coding RNA or computationally predicted genomic feature. Variants in such non-coding regions typically do not directly alter the amino acid sequence of a protein. Instead, when functional, they generally act by modulating local gene regulation, altering transcriptional enhancer activity, or influencing chromatin structure. Alternatively, variants like rs1104897 often serve as statistical proxies that are linked via linkage disequilibrium to functional mutations located elsewhere on the same chromosome. Public databases such as dbSNP catalogue this polymorphism as an intergenic or non-coding variant, meaning that uncovering its precise biological footprint requires detailed functional genomics assays.
Associations with Anthropometric and Physiological Measures
rs1104897 has been identified in high-throughput genome-wide association studies (GWAS) investigating population-level variation in human anthropometric traits and baseline physiological measures. Anthropometric measurements, which include metrics such as standing height, waist circumference, and body mass distribution, are classical complex traits driven by hundreds or thousands of distinct genetic loci across the genome. In these association studies, rs1104897 has shown modest statistical signals indicating that certain alleles correlate slightly with measurable physical differences. However, the evidence supporting these links is classified as limited. Complex human traits are governed by polygenic architecture, where any single locus contributes only an imperceptible fraction of the total phenotypic variance. Without consistent replication across independent cohorts and direct experimental validation, observed correlations should be treated as preliminary associations rather than definitive biological mechanisms.
Population Distribution and Allelic Frequency
According to large-scale sequencing and genotyping initiatives such as the 1000 Genomes Project and the Genome Aggregation Database (gnomAD), rs1104897 is a common polymorphism found across global populations. Both major and minor alleles circulate at high frequencies in diverse demographic groups, with particularly consistent representation documented in European and East Asian ancestry cohorts. Because the minor allele is widely distributed rather than rare, carrying one or two copies of this variant represents normal human genetic diversity rather than an unusual biological mutation. Subtle differences in allele frequency across distinct ancestries can influence the statistical power of association studies in specific cohorts, underscoring the critical need to interpret genetic association data within the appropriate ancestral and demographic context.
Interpreting Results and Practical Limitations
It is essential for readers to recognize what personal genomic data involving rs1104897 can and cannot convey. This variant is not a clinical diagnostic marker and cannot be used to predict disease onset, diagnose a medical condition, or guide therapeutic interventions. A common variant associated with an anthropometric trait does not deterministically define physical health, fitness, or metabolic outcomes. Physical traits and physiological markers are heavily influenced by lifestyle factors, nutrition, physical activity, and broad environmental influences, alongside thousands of additional genetic variants. Consequently, learning your rs1104897 genotype offers fascinating insight into your personal genome and human evolution, but it does not carry standalone clinical utility or mandate any changes to your daily lifestyle.
How common is this variant?
rs1104897 is a common genetic polymorphism frequently observed across diverse global populations, with well-documented representation in both European and East Asian cohorts.
Frequently asked questions
Does having a variant at rs1104897 cause a specific medical condition?
No, rs1104897 is not linked to any monogenic or high-penetrance medical disease. It is a common non-coding variant evaluated in association studies for subtle shifts in continuous physiological and anthropometric measurements.
What function does the LOC105377508 locus perform in the body?
LOC105377508 represents an uncharacterized, non-coding RNA locus rather than a standard protein-producing gene. Its exact regulatory roles or downstream cellular functions remain largely uncharacterized in modern molecular biology.
Can my rs1104897 genotype tell me my ideal body weight or height?
No, physical attributes like height and weight are highly polygenic and shaped by hundreds of thousands of genetic variants interacting with diet, environment, and physical activity. A single common polymorphism provides no meaningful personal predictive power.
Why is the evidence for rs1104897 described as limited?
The evidence is considered limited because the observed statistical signals from association studies have small effect sizes, lack direct functional laboratory verification, and may vary depending on the ancestral background of the cohorts studied.
Sources & further reading
Educational information only, last refreshed 9/9/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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