Understanding rs1104897: A Common Genetic Variant
The rs1104897 variant is a common genetic polymorphism located within the LOC105377508 gene region. It has been identified in various genome-wide association studies as a potential marker for certain anthropometric and physiological traits.
What each genotype means
Typical physiological baseline
You carry two copies of the A allele for rs1104897. Current genome-wide association studies suggest this genotype reflects the standard baseline profile for investigated anthropometric measures and physiological traits. Evidence remains limited and non-diagnostic, representing subtle statistical shifts rather than direct health consequences.
Carried by approximately 20% to 35% of individuals across European and East Asian cohorts.
Intermediate trait profile
You carry one copy of the A allele and one copy of the G allele for rs1104897. Genome-wide screens have linked this locus to modest variation in measured physical and anthropometric traits. Because the clinical evidence is limited, this heterozygous genotype confers only subtle statistical tendencies without causing defined symptoms.
Carried by approximately 45% to 50% of individuals in most global populations, representing the most common genotype.
Associated trait variation
You carry two copies of the G allele for rs1104897. Published association data indicate a minor statistical shift in anthropometric and physiological parameters compared to non-carriers. Given that available research is exploratory and limited, this variation has minor influence on everyday health.
Carried by roughly 20% to 30% of people of European and East Asian ancestry.
What is rs1104897?
A single nucleotide polymorphism, or SNP, is a variation at a single position in a DNA sequence among individuals. The variant rs1104897 represents a specific location in the human genome where a single base pair change occurs. In the context of genetic research, SNPs like rs1104897 are often studied to understand how small differences in our DNA sequence might contribute to the diversity of human physical characteristics. This particular variant is situated within the genomic region associated with the LOC105377508 gene. Because it is a common polymorphism, it is found frequently across many different human populations, making it a subject of interest for researchers looking to map the genetic architecture of complex traits. It is important to note that the presence of a specific SNP does not determine a trait on its own; rather, it is one of many thousands of variations that researchers analyze to build a broader picture of human biology.
The Role of LOC105377508
The variant rs1104897 is mapped to the LOC105377508 gene region. In genomics, 'LOC' identifiers are often used for loci that have been identified through computational analysis but may not yet have a fully characterized protein-coding function or a well-established biological role in the literature. Research into such regions is ongoing, as scientists work to determine whether these sequences act as regulatory elements, non-coding RNAs, or other functional components of the genome. Because the functional impact of the LOC105377508 region is still being explored, the specific biological mechanism by which rs1104897 might influence a trait remains largely theoretical. Geneticists use large-scale studies to observe correlations between these regions and physical measurements, but establishing a direct causal link requires extensive functional validation in laboratory settings. As genomic databases continue to be updated, our understanding of the role this gene plays in human physiology will likely become more precise.
Research and Evidence Strength
The evidence linking rs1104897 to specific human traits is currently classified as limited. This classification is common in the field of genome-wide association studies (GWAS), where researchers scan the entire genome to find statistical associations between variants and traits. While these studies are powerful tools for identifying potential genetic signals, a 'limited' evidence strength indicates that the findings may not yet be robustly replicated across diverse cohorts or that the effect size of the variant is very small. The GWAS Catalog tracks these associations, noting that rs1104897 has appeared in studies evaluating anthropometric measures—such as body dimensions—and various physiological traits. However, because many factors, including environment, lifestyle, and thousands of other genetic variants, influence these traits, it is difficult to isolate the impact of a single SNP. Consumers should view these associations as preliminary statistical observations rather than definitive predictors of health or physical outcomes.
Interpreting Your Genetic Information
When you encounter information about variants like rs1104897, it is essential to understand that this data is for educational purposes only. You cannot use this information to diagnose a medical condition, predict your future health, or make decisions about your lifestyle or medical care. Genetic associations are population-level statistics, not individual-level medical advice. If you have questions about your health or how your genetics might influence your physical traits, the best course of action is to consult with a qualified healthcare professional or a genetic counselor. They can help you interpret your health history in the context of your overall well-being. Furthermore, if you are ever concerned about medication responses or specific health risks, always discuss these topics with your clinician or pharmacist. They are equipped to provide personalized guidance based on clinical evidence, which is far more reliable than individual SNP data alone.
How common is this variant?
The rs1104897 variant is a common polymorphism, meaning it is frequently observed across both European and East Asian ancestral cohorts.
Frequently asked questions
What does it mean if a variant has 'limited' evidence?
Limited evidence means that while some studies have observed a statistical link between the variant and a trait, the findings are not yet considered definitive. It often suggests that more research is needed to confirm the association across different populations or to understand the underlying biology.
Can I use rs1104897 to predict my height or weight?
No. Anthropometric traits like height and weight are complex and influenced by thousands of genetic variants, as well as significant environmental and lifestyle factors. A single SNP like rs1104897 has a negligible impact on these traits.
Where can I find more information about my specific genotype?
You can look up your specific SNP data in your raw genetic report if you have taken a direct-to-consumer test. However, for medical interpretation, you should always consult with a healthcare provider who can review your results in the context of your full medical history.
Is rs1104897 associated with any diseases?
Current research in the GWAS Catalog focuses on anthropometric and physiological traits rather than specific disease states. There is no established clinical evidence linking this variant to a specific disease diagnosis.
Sources & further reading
Educational information only, last refreshed 10/13/2026. Not medical advice — these associations describe population statistics, not individual predictions.
Curious what your genotype is for rs1104897?
Upload a raw DNA file from 23andMe, AncestryDNA, MyHeritage, or FamilyTreeDNA and see this variant — plus thousands more — interpreted in your full report.
Get my report — $29