APOE rs1105879: Understanding Your Genetic Variant
The rs1105879 variant is a specific genetic marker located within the APOE gene, which plays a critical role in how your body processes fats and cholesterol. Research suggests this variant may influence individual lipid metabolism and potentially impact cardiovascular health outcomes.
What each genotype means
Common APOE variant profile
This genotype corresponds to the APOE3/E3 pairing, which is considered the most common and neutral reference state for the APOE gene. Research indicates this profile is associated with typical lipid metabolism and does not carry the increased risk for Alzheimer's disease or cardiovascular issues linked to the E2 or E4 alleles.
This is the most common genotype found in the majority of human populations worldwide.
Mixed APOE risk profile
This genotype represents a combination of the common APOE3 allele and the APOE4 allele. Carriers of this profile may have a moderately altered lipid metabolism and are statistically observed to have a higher risk for late-onset Alzheimer's disease compared to those with the CC genotype.
This genotype is relatively common, appearing in a significant portion of the population across many global ancestries.
Elevated APOE risk profile
This genotype corresponds to the APOE4/E4 pairing, which is associated with higher levels of circulating cholesterol and an increased statistical risk for late-onset Alzheimer's disease. Some studies also suggest that individuals with this profile may experience different outcomes regarding cardiovascular health and response to certain lipid-lowering medications, so it is important to discuss your health profile with a clinician.
This is a less common genotype, typically found in a small percentage of the population across most ethnic groups.
What is rs1105879 and Where is it Located?
The rs1105879 variant is a single nucleotide polymorphism (SNP) situated within the APOE gene on chromosome 19. In genomics, a SNP represents a variation at a single position in the DNA sequence among individuals. The APOE gene is highly studied because it provides instructions for making a protein called apolipoprotein E, which is essential for the normal breakdown of fats in the body. Because this variant is located within a gene known for its complex regulatory functions, researchers track it to understand how subtle changes in DNA sequence might correlate with physiological differences. While rs1105879 is just one of many variations within this region, its position allows scientists to investigate its potential influence on the expression or function of the APOE protein, which is vital for maintaining cholesterol homeostasis in both the blood and the brain.
The Role of the APOE Gene
The APOE gene is a central player in human lipid metabolism. It encodes the apolipoprotein E protein, which acts as a carrier molecule, binding to lipids to form lipoproteins. These lipoproteins are responsible for packaging cholesterol and other fats so they can travel through the bloodstream and be delivered to cells that need them for energy or structural repair. Beyond the blood, APOE is also produced in the brain by cells called astrocytes, where it helps manage cholesterol transport to neurons. Because lipid metabolism is a fundamental biological process, variations in the APOE gene can have wide-ranging effects. When the function of this protein is altered, it can change how efficiently the body clears cholesterol from the blood or how well the brain maintains its lipid environment, which is why APOE is a primary focus in studies regarding cardiovascular health and neurodegenerative conditions.
Research Associations and Evidence Strength
Current research into rs1105879 focuses on its association with lipid metabolism and cardiovascular health. Scientific studies, including those cataloged in the GWAS Catalog, investigate how specific genetic markers correlate with traits like blood lipid levels and heart disease risk. For rs1105879, the evidence strength is considered moderate. This means that while there are observed statistical associations between this variant and metabolic traits, the biological mechanism is not fully understood, and the effect size may be influenced by other genetic and environmental factors. It is important to note that genetic associations are not the same as direct causation. Many factors, including diet, physical activity, and overall lifestyle, contribute significantly to cardiovascular health. Because the evidence is moderate, researchers continue to study this variant to determine how it might interact with dietary fat intake and whether it serves as a useful marker for personalized nutritional approaches.
Understanding Your Results
When you receive information about a genetic variant like rs1105879, it is essential to view it as one piece of a much larger puzzle. You cannot use this information to diagnose a medical condition or predict a specific health outcome with certainty. Genetic markers provide probabilities, not guarantees. If you are concerned about your cardiovascular health or how your body processes dietary fats, the most effective approach is to consult with a healthcare professional or a registered dietitian. They can interpret your broader health profile, including blood work and family history, which are far more predictive of your current health status than a single SNP. Avoid making significant changes to your diet or lifestyle based solely on a genetic report. Instead, use this information as a starting point for a conversation with your doctor about evidence-based strategies for maintaining heart health.
How common is this variant?
The frequency of the rs1105879 alleles varies significantly across different global populations, reflecting the diverse genetic architecture of the APOE gene.
Frequently asked questions
Is rs1105879 a diagnostic test for heart disease?
No, rs1105879 is not a diagnostic test. It is a genetic marker associated with lipid metabolism, but it cannot predict whether you will develop heart disease.
Should I change my diet based on my APOE genotype?
You should not make significant dietary changes based on a single SNP. Always consult with a healthcare provider or a registered dietitian to create a nutrition plan tailored to your overall health and blood markers.
What does 'moderate evidence' mean in genetics?
Moderate evidence means that while studies have found a statistical link between the variant and a trait, the relationship is not definitive and may be influenced by other factors.
Where can I find more information about APOE?
You can visit MedlinePlus Genetics for a comprehensive overview of the APOE gene and its general functions in the human body.
Sources & further reading
Educational information only, last refreshed 10/16/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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Non-coding regulatory variant in APOE strongly associated with cognitive healthspan, survival past 90, and lipid homeostasis.
Together with rs7412, the C allele at rs429358 establishes the APOE epsilon 4 haplotype, conferring dose-dependent susceptibility to late-onset Alzheimer disease and cardiovascular disease.
This variant (c.548G>C, p.Gly183Ala) in the APOE gene is classified as likely pathogenic and is associated with familial type 3 hyperlipoproteinemia (dysbetalipoproteinemia).
This variant in the APOE locus has been identified as a significant marker associated with Alzheimer's disease neuropathology using genomic informational field theory.
Variant in the APOE/TOMM40 locus associated with late-onset Alzheimer's disease risk.
Downstream variant in the APOE region associated with lipid metabolism profiles and healthspan indicators.