NPAS2 rs11123857: What Your Genotype Means
The rs11123857 variant is a common genetic change located within the NPAS2 gene, which plays a critical role in the body's internal circadian clock. Research has identified associations between this variant and variations in mood stability and sleep-related behaviors.
What each genotype means
Baseline risk profile
This genotype represents the baseline state for this variant in the NPAS2 gene. Research indicates that individuals with this genotype do not show the increased statistical association with mood disorders observed in carriers of the G allele.
This is a common genotype found in many global populations.
Slightly increased mood risk
Carrying one copy of the G allele has been associated in some studies with a 1.44-fold increased statistical risk of developing bipolar disorder or major depression. Because this is a complex trait influenced by many factors, this result should not be interpreted as a diagnosis or a prediction of future health.
This genotype is commonly observed across various ancestral groups.
Increased mood risk
Carrying two copies of the G allele is associated in some research with a 2.88-fold increased statistical risk of bipolar disorder or major depression compared to those without the G allele. Please remember that genetic associations are only one part of overall health, and you should discuss any concerns about mood or sleep with a qualified healthcare professional.
This genotype is found at common frequencies in many populations worldwide.
Understanding the rs11123857 Variant
The rs11123857 variant is a single nucleotide polymorphism (SNP) located within the NPAS2 gene. In genetics, a SNP represents a variation at a single position in the DNA sequence among individuals. This specific variant has been identified through genome-wide association studies (GWAS) as a marker of interest due to its location within a gene known to influence biological timing. Because it is a common variant, it is found frequently across diverse human populations. Scientists study such variants to understand how subtle differences in our genetic code might contribute to the wide range of human behaviors and physiological traits, particularly those related to the timing of our daily activities and emotional regulation.
The Role of the NPAS2 Gene
The NPAS2 gene, or Neuronal PAS Domain Protein 2, encodes a protein that acts as a key component of the circadian clock. This internal time-keeping system regulates approximately 24-hour rhythms in gene expression, which in turn influence metabolism, sleep, and behavior. NPAS2 functions by integrating transcriptional control with broader physiological timing, helping the body adapt to the cycle of day and night. It is particularly active in the brain, where it influences pathways related to neurotransmission. By regulating the rhythmic expression of various genes, NPAS2 ensures that our internal processes are synchronized with the environment. Disruptions or variations in this gene are often investigated for their potential impact on sleep-wake cycles and mood-related phenotypes.
Research and Evidence Strength
Scientific research has explored the link between NPAS2 and various health-related traits. Specifically, studies have identified nominal statistical associations between the rs11123857 variant and mood-related outcomes in certain patient populations. While these findings are significant in a research context, the evidence strength is generally considered moderate. It is important to note that complex traits like mood and sleep are polygenic, meaning they are influenced by many different genes, environmental factors, and lifestyle choices. Therefore, a single SNP like rs11123857 provides only a small piece of a much larger, complex puzzle. Current research continues to move toward larger, more diverse studies to better understand how these genetic markers interact with other biological and environmental variables to influence human health.
Interpreting Your Genetic Information
When considering information about genetic variants like rs11123857, it is essential to maintain a balanced perspective. This variant is a common feature of the human genome and is not a diagnostic tool for any medical condition. Genetic associations observed in research studies describe trends across large groups of people and cannot predict individual outcomes. You cannot use this information to diagnose yourself or others, nor should it be used to make medical decisions. If you have concerns about your sleep patterns, mood, or overall well-being, the most effective approach is to consult with a qualified healthcare professional. They can provide personalized guidance based on your clinical history, symptoms, and professional medical evaluation, rather than relying on isolated genetic data.
How common is this variant?
The rs11123857 variant is considered a common polymorphism, with its genotypes appearing at varying frequencies across different global ancestral populations.
Frequently asked questions
Is rs11123857 a diagnostic test for mood disorders?
No, rs11123857 is not a diagnostic test. It is a genetic variant associated with traits in research studies, but it cannot be used to diagnose any medical or psychiatric condition.
What does the NPAS2 gene do?
The NPAS2 gene produces a protein that helps regulate the body's circadian clock. This system controls daily rhythms in sleep, metabolism, and behavior.
Should I change my medication based on this SNP?
No. You should never change your medication or treatment plan based on genetic information without first consulting your doctor or pharmacist.
Why do studies show different results for this variant?
Genetic studies often show mixed results because complex traits are influenced by many genes, environmental factors, and differences in study population ancestry.
Sources & further reading
Educational information only, last refreshed 9/24/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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