FARSA-AS1 rs111757774: What Your Genotype Means
The genetic variant rs111757774 is a single nucleotide polymorphism located within the FARSA-AS1 gene. Research has identified an association between this variant and variations in mean corpuscular hemoglobin (MCH) levels, which are clinical markers used to assess red blood cell health.
What each genotype means
Typical hemoglobin marker profile
This genotype represents the most common genetic sequence observed at this location. Research indicates that this variant is associated with variations in mean corpuscular hemoglobin, a measure of the average amount of hemoglobin per red blood cell, but this specific genotype is considered the baseline for comparison.
This is the most common genotype found across all major global populations.
Variant hemoglobin marker association
Carrying this genotype means you have one copy of the variant associated with differences in mean corpuscular hemoglobin levels. Because this variant is rare, the clinical significance of this specific association is still being studied and should not be used to diagnose any blood-related conditions.
This genotype is extremely rare and is observed in a very small fraction of the global population.
Rare variant hemoglobin association
This genotype indicates you carry two copies of the variant associated with differences in mean corpuscular hemoglobin levels. Current evidence is limited regarding the specific physiological impact of this homozygous state, and it is not a diagnostic marker for red blood cell health.
This genotype is exceptionally rare and has not been widely documented in large-scale population databases.
Understanding the Variant
The variant rs111757774 is a specific change in the DNA sequence, categorized as a single nucleotide polymorphism (SNP). It is situated within the genomic region of FARSA-AS1, which stands for FARSA Antisense RNA 1. In genetics, an antisense RNA is a type of long non-coding RNA (lncRNA) that is transcribed from the opposite strand of a protein-coding gene. While protein-coding genes provide the instructions for building proteins, lncRNAs like FARSA-AS1 often play regulatory roles in the cell, influencing how other genes are expressed. Because rs111757774 is located in this regulatory region, researchers study it to understand if and how it might influence the biological processes related to blood cell development and maintenance.
The Role of FARSA-AS1
FARSA-AS1 is classified as a long non-coding RNA. Unlike messenger RNA, which acts as a template for protein synthesis, lncRNAs are involved in complex cellular activities, including the regulation of gene expression, chromatin remodeling, and cellular signaling. The gene name is derived from its proximity to the FARSA gene, which encodes the alpha subunit of the cytoplasmic phenylalanine-tRNA synthetase enzyme. This enzyme is essential for protein biosynthesis. While the specific function of the FARSA-AS1 transcript itself is still being characterized by the scientific community, its genomic location suggests it may be involved in the regulatory landscape surrounding the FARSA gene. Understanding these regulatory elements is a key focus of modern genomics, as they help explain how subtle variations in non-coding DNA can contribute to observable differences in human physiological traits.
Research and Associations
The association between rs111757774 and mean corpuscular hemoglobin (MCH) has been identified through Genome-Wide Association Studies (GWAS). MCH is a measurement of the average amount of hemoglobin present in a single red blood cell. It is a standard parameter in a complete blood count (CBC) test, often used by clinicians to help classify different types of anemia. The evidence linking this specific SNP to MCH levels is considered moderate, as it has been highlighted in large-scale genetic databases like the GWAS Catalog. It is important to note that while a statistical association exists, this does not imply that the variant causes a medical condition. Genetic associations are complex, and many factors, including environment and other genetic markers, contribute to an individual's blood cell parameters.
Population Frequency
The variant rs111757774 is classified as rare in the general population. Because it is rare, it is not frequently observed in standard genetic screening panels, and its distribution across different ancestral groups is still being mapped by large-scale genomic projects. Rare variants often provide unique insights into human biology, but their limited frequency means that researchers must study large cohorts to confirm the strength and consistency of their associations with specific traits like MCH. As more individuals participate in genomic research, our understanding of how common or rare this variant is across diverse global populations will continue to improve, providing a clearer picture of its role in human genetic diversity.
Interpreting Your Results
If you have information about your genotype for rs111757774, it is important to view it in the proper context. This variant is associated with minor variations in a blood marker, not a diagnosis of a disease. Mean corpuscular hemoglobin levels are influenced by a wide array of factors, including nutrition, iron status, and overall health. You cannot use this genetic information to diagnose yourself or to make decisions about your health or medical care. If you are concerned about your blood test results or your health, you should consult with a qualified healthcare professional. They can interpret your clinical blood work in the context of your full medical history and provide appropriate guidance. Never change your diet, lifestyle, or medical treatment based on a single genetic variant.
How common is this variant?
The variant rs111757774 is considered rare across most studied populations, meaning it is not commonly found in the general public.
Frequently asked questions
What is mean corpuscular hemoglobin?
Mean corpuscular hemoglobin (MCH) is a measurement of the average amount of hemoglobin in a single red blood cell. It is a standard value reported in a complete blood count (CBC) test.
Does having this variant mean I have anemia?
No. An association with MCH levels does not mean you have a medical condition like anemia. MCH is just one of many factors doctors look at when evaluating blood health.
Can I change my genotype for rs111757774?
No. Your genotype is determined by the DNA you inherited from your parents and remains the same throughout your life.
Should I be worried about this variant?
There is no reason for concern. This variant is a normal part of human genetic variation and is associated with minor differences in a blood marker, not a disease.
Where can I learn more about my blood health?
The best way to learn about your blood health is to speak with your primary care physician. They can order appropriate blood tests and explain what the results mean for you.
Sources & further reading
Educational information only, last refreshed 9/15/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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