MED13L rs11263535: What Your Genotype Means
The rs11263535 variant is a single nucleotide polymorphism located within the MED13L gene. It has been identified in large-scale association studies as being linked to variations in certain anthropometric and metabolic phenotypes.
What each genotype means
Typical metabolic trait baseline
You carry two copies of the C allele at rs11263535 in the MED13L locus. In large-scale population association studies, this genotype reflects the standard baseline profile for investigated anthropometric and metabolic phenotypes. Current scientific evidence for this common non-coding variant remains limited and does not indicate any diagnostic health consequence or clinically actionable change.
Carried by approximately 56% of individuals across global populations.
Slight variation in metabolic traits
You carry one copy of the T allele and one copy of the C allele at rs11263535. Genome-wide association meta-analyses have noted modest statistical shifts in certain anthropometric or metabolic measures with this heterozygous genotype. However, because scientific evidence is limited and effect sizes are very small, this variant does not determine individual health outcomes or replace standard clinical evaluations.
Carried by approximately 38% of individuals globally.
Slight variation in metabolic traits
You carry two copies of the T minor allele at rs11263535 near the MED13L gene. Large genome-wide association studies have identified modest correlations between this genotype and small variations in anthropometric and metabolic phenotypes. The available evidence is limited to minor statistical associations across populations and does not suggest any diagnostic disease risk or require medical action.
Carried by approximately 6% of people globally.
Understanding the rs11263535 Variant
The rs11263535 variant is a specific genetic change, or single nucleotide polymorphism (SNP), found within the human genome. In the context of genetic research, SNPs are the most common type of genetic variation among people. Each SNP represents a difference in a single DNA building block, called a nucleotide. The rs11263535 variant is situated within the MED13L gene, which provides instructions for creating a protein that serves as a subunit of the mediator complex. This complex is essential for regulating gene transcription, the process by which DNA is copied into RNA to build proteins. Because this variant is located in a gene involved in complex cellular signaling and developmental pathways, researchers study it to understand how subtle differences in our genetic code might contribute to observable variations in human physical and metabolic traits.
The Role of the MED13L Gene
The MED13L gene, located on chromosome 12, encodes the mediator complex subunit 13L protein. This protein is a critical component of the Mediator complex, which acts as a bridge between various transcription factors and the RNA polymerase II machinery required for gene expression. By facilitating this interaction, MED13L helps control the activity of many genes involved in early development, including those that guide the formation of the heart, brain, and craniofacial structures. Beyond its developmental roles, the Mediator complex is involved in diverse cellular activities such as cell growth, migration, and differentiation. While rare, severe mutations in MED13L are known to cause a specific neurodevelopmental disorder characterized by intellectual disability and physical malformations. However, common variants like rs11263535 are generally studied for their much smaller, cumulative effects on common physiological traits rather than for causing rare genetic syndromes.
Research Associations and Evidence Strength
The association between rs11263535 and human traits is primarily derived from large-scale genome-wide association studies (GWAS). These studies scan the genomes of thousands of individuals to identify statistical links between specific genetic variants and measurable traits, such as body measurements or metabolic markers. According to the GWAS Catalog, rs11263535 has been associated with variations in anthropometric and metabolic phenotypes. It is important to note that the evidence strength for this specific variant is considered limited. In the field of genomics, a 'limited' association means that while a statistical signal has been observed, the biological mechanism explaining how this specific SNP influences a trait is not yet fully understood. Furthermore, these associations are often based on population-level averages and may not be predictive for any single individual. As with many complex traits, these phenotypes are likely influenced by a combination of many genetic variants and environmental factors.
Interpreting Your Genetic Information
When reviewing information about variants like rs11263535, it is essential to maintain a clear perspective on what this data means. Genetic associations identified in research studies describe patterns across large groups of people, not individual health outcomes. Because the evidence for this variant is limited, it should not be used to make medical decisions or to predict personal health risks. If you have questions about your metabolic health, body composition, or any other physical trait, the most reliable approach is to consult with a qualified healthcare professional. They can evaluate your health status using established clinical markers rather than relying on individual genetic variants. Always remember that your health is the result of a complex interplay between your genetics, your lifestyle, and your environment, and no single SNP can provide a complete picture of your well-being.
How common is this variant?
The rs11263535 variant has a minor allele frequency of approximately 0.25 across global populations, meaning the minor allele is present in about one-quarter of the chromosomes studied.
Frequently asked questions
What does it mean if a genetic association is 'limited'?
A 'limited' association means that while researchers have found a statistical correlation between a variant and a trait, the evidence is not yet strong enough to confirm a direct biological cause. It often suggests that the effect size is small or that more research is needed to replicate the findings.
Can I use this SNP to predict my risk for metabolic disease?
No. This variant is associated with minor variations in traits, not the diagnosis of disease. Metabolic health is complex and influenced by many factors, so you should rely on clinical testing and professional medical advice.
Is MED13L related to serious genetic disorders?
Yes, rare and severe mutations in the MED13L gene can cause a specific neurodevelopmental disorder. However, common variants like rs11263535 are distinct from these rare, pathogenic mutations and are studied in the context of normal human variation.
Where can I find more information about my specific genetic results?
If you have received genetic testing results, you should discuss them with a genetic counselor or your primary care physician. They can help you interpret the information in the context of your personal and family health history.
Sources & further reading
Educational information only, last refreshed 10/13/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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