NR1I3 rs11265572: What Your Genotype Means
The rs11265572 variant is a single nucleotide polymorphism located within the NR1I3 gene. It has been studied for its potential influence on how the body processes the immunosuppressant medication tacrolimus in kidney transplant patients.
What each genotype means
Typical genotype
This genotype represents the most common form of this variant in many populations. Research investigating this variant's potential link to tacrolimus trough concentrations in kidney transplant recipients has not established a clear clinical impact for this specific genotype. Please discuss any medication dosing concerns with your clinician or pharmacist.
This is the most common genotype observed in many global populations.
Heterozygous genotype
You carry one copy of the G allele and one copy of the T allele. Studies attempting to validate the association between this variant and tacrolimus levels in kidney transplant patients have not found a significant difference in drug concentrations for carriers of the T allele compared to the G allele. Please discuss any medication dosing concerns with your clinician or pharmacist.
This genotype is found at varying frequencies across different ancestral groups.
Variant genotype
You carry two copies of the T allele. Current research, including validation studies in kidney transplant recipients, has not demonstrated that this genotype significantly alters tacrolimus trough concentrations compared to other genotypes. Please discuss any medication dosing concerns with your clinician or pharmacist.
This genotype is less common than the GG genotype in most studied populations.
Understanding the rs11265572 Variant
The rs11265572 variant is a specific genetic change, or single nucleotide polymorphism (SNP), found within the human genome. In the context of genetic research, a SNP represents a variation at a single position in the DNA sequence among individuals. This particular variant is situated within the NR1I3 gene, which provides instructions for creating a protein that acts as a nuclear receptor. Scientists track these variants to determine if they correlate with differences in how individuals respond to environmental factors, including medications. Because rs11265572 is located in a region involved in regulating metabolic processes, it has become a subject of interest in pharmacogenomics—the study of how genes affect a person's response to drugs. Researchers examine such variants to see if they might explain why some patients require different medication doses to achieve the same therapeutic effect.
The Role of the NR1I3 Gene
The NR1I3 gene encodes the nuclear receptor subfamily 1 group I member 3, also known as the constitutive androstane receptor (CAR). This protein functions as a transcription factor, meaning it helps control the activity of other genes. Specifically, the NR1I3 protein is a key regulator of xenobiotic and endobiotic metabolism. Xenobiotics are foreign chemical substances, such as drugs or toxins, that enter the body. By sensing these substances, the NR1I3 protein can trigger the expression of enzymes and transporters that help the body break down and eliminate these compounds. Because of this regulatory role, variations in the NR1I3 gene are hypothesized to potentially alter the efficiency of drug metabolism. Understanding how this gene functions is essential for researchers investigating why drug concentrations in the blood can vary significantly from one person to another.
Research and Evidence Strength
The association between rs11265572 and medication response is currently considered to have limited evidence. Specifically, researchers have investigated whether this variant influences the trough concentrations of tacrolimus, an immunosuppressant drug commonly used to prevent organ rejection in kidney transplant recipients. Some studies have attempted to validate whether carrying specific alleles at this position correlates with higher or lower levels of the drug in the blood. However, results have been mixed or inconclusive. For instance, some research efforts aimed at validating previously reported associations in large cohorts of African American and European American kidney transplant patients did not find a significant link between the T allele and tacrolimus trough concentrations. Because the evidence is not robust or consistent across different populations, this variant is not currently used in standard clinical practice to guide tacrolimus dosing.
What This Information Means for You
If you have received information about your rs11265572 genotype, it is important to understand that this data is primarily used for research purposes rather than clinical decision-making. Because the evidence linking this variant to tacrolimus metabolism is limited and inconsistent, it cannot be used to predict how you will respond to medication. Genetic factors are only one piece of a complex puzzle that includes age, weight, liver and kidney function, and other medications you may be taking. You should never use genetic information to adjust your medication dosage or stop taking a prescribed treatment. If you are a transplant recipient or are taking tacrolimus, always discuss your dosing and any concerns about your medication levels directly with your transplant team, clinician, or pharmacist. They are the only ones qualified to interpret your clinical data and make safe adjustments to your treatment plan.
How common is this variant?
The frequency of the rs11265572 variant is variable and differs significantly across global populations, reflecting the diverse genetic architecture of human ancestries.
Frequently asked questions
Can I use my rs11265572 result to change my tacrolimus dose?
No. You should never change your medication dosage based on genetic test results. Always consult your transplant physician or pharmacist before making any changes to your prescribed treatment.
Is rs11265572 a reliable predictor of drug response?
No. The current scientific evidence for this variant is limited and inconsistent. It is not considered a reliable or validated predictor for clinical drug dosing.
What does the NR1I3 gene do?
The NR1I3 gene encodes a protein that acts as a sensor for foreign substances in the body. It helps regulate the enzymes responsible for metabolizing drugs and other chemicals.
Why do my tacrolimus levels change?
Tacrolimus levels are influenced by many factors, including your kidney and liver function, diet, other medications, and your overall health. Genetic variants are only one of many variables that doctors consider.
Sources & further reading
Educational information only, last refreshed 9/25/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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