CRP rs1130864: What Your Genotype Means
The rs1130864 variant is a single nucleotide polymorphism located in the 3' untranslated region of the CRP gene. It is statistically associated with variations in baseline circulating levels of high-sensitivity C-reactive protein (hs-CRP) in human populations.
What each genotype means
Baseline CRP level profile
This genotype is associated with lower baseline circulating levels of high-sensitivity C-reactive protein (hs-CRP) compared to those carrying the T allele. Research indicates that while this variant influences inflammatory markers, it does not show a direct causal association with coronary heart disease risk.
This is the most common genotype in many populations, particularly among those of European ancestry.
Intermediate CRP level profile
Carrying one copy of the T allele is associated with higher baseline circulating levels of high-sensitivity C-reactive protein (hs-CRP) compared to the CC genotype. Some studies have observed an association between this genotype and an increased risk of certain inflammatory conditions, such as H. pylori-associated chronic gastritis, though evidence regarding broader disease outcomes remains limited.
This genotype is carried by a significant portion of the population, with the T allele frequency reaching approximately 0.25–0.30 in European ancestries.
Elevated CRP level profile
This genotype is associated with the highest baseline circulating levels of high-sensitivity C-reactive protein (hs-CRP) among the three genotypes. Individuals with this profile may show a stronger statistical association with certain inflammatory-related conditions, though it is not considered a diagnostic marker for heart disease.
This is the least common genotype, occurring less frequently than the CC or CT genotypes in most studied populations.
Understanding the rs1130864 Variant
The rs1130864 variant is a specific genetic change, often referred to as a single nucleotide polymorphism or SNP, located within the CRP gene on chromosome 1. Specifically, it is situated in the 3' untranslated region (3' UTR), a segment of the gene that does not code for protein but plays a critical role in regulating gene expression, such as the stability of messenger RNA. In the context of this variant, the change involves a substitution of one nucleotide for another, often documented as a C to T change. Because it sits in a regulatory region, researchers have long investigated whether this specific location influences how much C-reactive protein the body produces. Genetic variants like rs1130864 are identified through large-scale genomic studies that compare DNA sequences across diverse groups of people to find patterns that correlate with measurable biological traits.
The Role of the CRP Gene
The CRP gene provides the instructions for creating C-reactive protein, a substance produced by the liver. This protein is a member of the pentraxin family and acts as a key component of the body's innate immune system. When inflammation occurs anywhere in the body, the liver increases the production of CRP, which then travels through the bloodstream to help clear out damaged cells and pathogens. Because of this, clinicians often measure hs-CRP levels in the blood as a general marker of systemic inflammation. While CRP is a normal and necessary part of the immune response, the amount of protein circulating in the blood can vary significantly between healthy individuals due to a combination of environmental factors, lifestyle, and inherited genetic variations like rs1130864.
Research Associations and Evidence
Scientific research has consistently identified a statistical association between the rs1130864 variant and baseline levels of circulating hs-CRP. Multiple studies have observed that individuals carrying different alleles at this position show measurable differences in their average CRP concentrations. While these associations are statistically significant in various cohorts, the evidence regarding the clinical impact of these differences remains limited. Researchers have explored whether these genetic influences on CRP levels correlate with long-term health outcomes, such as cardiovascular disease or inflammatory conditions. However, current findings are mixed, and it is not yet fully understood to what extent these genetic variations directly contribute to disease risk versus simply reflecting natural biological variation. As with many complex traits, CRP levels are influenced by a wide array of genetic and non-genetic factors, making it difficult to isolate the effect of a single SNP.
Interpreting Your Genetic Information
It is important to understand that having a specific genotype for rs1130864 does not serve as a medical diagnosis or a definitive predictor of future health. Genetic associations are based on population-level data, which describe trends across large groups rather than the specific health trajectory of an individual. If you have received information about your genotype for this variant, it is best viewed as a small piece of a much larger biological puzzle. You cannot use this information to diagnose yourself with an inflammatory condition or to determine your risk for heart disease. If you have concerns about your hs-CRP levels or your cardiovascular health, the most appropriate step is to consult with a healthcare professional. They can interpret your blood test results in the context of your overall health history, lifestyle, and other clinical markers, which are far more informative than a single genetic variant.
How common is this variant?
The minor allele (T) frequency is approximately 0.25–0.30 in European populations and 0.10–0.15 in African ancestries.
Frequently asked questions
What does the rs1130864 variant do?
The rs1130864 variant is a genetic change in the CRP gene that is associated with differences in the baseline levels of C-reactive protein in the blood. It is located in a regulatory region of the gene.
Does this variant cause inflammation?
No, this variant does not cause inflammation. It is simply a genetic marker that has been statistically linked to the amount of C-reactive protein your body produces under normal, baseline conditions.
Should I be worried if I have the T allele?
There is no reason for concern based on this genotype alone. Genetic variants are common, and this SNP is just one of many factors that influence your body's baseline protein levels.
Can I change my CRP levels?
CRP levels are influenced by lifestyle factors such as diet, exercise, and smoking. If you are concerned about your CRP levels, you should discuss testing and management strategies with your doctor.
Sources & further reading
Educational information only, last refreshed 10/16/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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