rs113288717: Understanding This Intergenic Variant
The genetic variant rs113288717 is a single nucleotide polymorphism located in an intergenic region on chromosome 19. Recent research has identified a statistical association between this variant and cognitive impairment in populations of long-living adults.
What each genotype means
Typical cognitive risk profile
This genotype represents the most common form of this variant in many populations. Research suggests this version is not associated with the increased risk of cognitive impairment observed in carriers of the alternative allele.
Carried by the majority of individuals in most global populations.
Potential cognitive risk association
Carrying one copy of the G allele has been associated in some studies with a higher likelihood of cognitive impairment in long-living adults. This association is based on statistical trends in population-level research and does not predict individual cognitive outcomes.
Carried by a small minority of the population, consistent with the reported minor allele frequency of approximately 0.037.
Elevated cognitive risk association
Carrying two copies of the G allele is statistically associated with a higher risk of cognitive impairment in older age groups compared to those without the variant. Because this is a complex trait influenced by many genetic and environmental factors, this result should be viewed as a general association rather than a diagnostic indicator.
This homozygous genotype is rare, occurring in a very small fraction of the population based on the reported minor allele frequency.
What is rs113288717?
A single nucleotide polymorphism, or SNP, is a variation at a single position in a DNA sequence among individuals. The variant rs113288717 is classified as an intergenic variant, meaning it is located in the non-coding DNA sequence between genes rather than within a gene that codes for a protein. Because it sits in an intergenic region, it does not directly alter the amino acid sequence of a protein. Instead, researchers investigate such variants to see if they influence the regulation of nearby genes or serve as markers for other functional genetic changes. Located on chromosome 19, this specific site has been highlighted in genome-wide association studies (GWAS) that look for correlations between specific genetic markers and complex health-related traits in aging populations.
Research and Cognitive Health
The evidence linking rs113288717 to health outcomes is derived from GWAS, which scan the genomes of large groups of people to find statistical associations between variants and specific traits. In the context of aging, researchers have observed an association between this variant and cognitive impairment in long-living adults. It is important to note that this evidence is considered moderate. GWAS results identify correlations, not direct causes; the presence of a variant does not guarantee a specific health outcome. Furthermore, cognitive health is a complex trait influenced by a combination of many genetic factors, environmental exposures, and lifestyle choices. Because this variant is intergenic, the biological mechanism by which it might influence cognitive function remains a subject of ongoing scientific inquiry rather than established medical fact.
Interpreting Your Genetic Information
When encountering information about genetic variants like rs113288717, it is essential to maintain a clear perspective on what this data means. Genetic associations are statistical observations made across large groups and cannot be used to predict an individual's health or diagnose a condition. You cannot use this information to make medical decisions or change your lifestyle habits without professional guidance. If you are concerned about cognitive health or memory, the most appropriate step is to consult with a healthcare provider or a neurologist. They can evaluate your personal health history, perform clinical assessments, and provide context that a single genetic marker cannot offer. Always prioritize clinical evaluations over findings from genetic databases, as your overall health is determined by a vast array of factors beyond any single SNP.
How common is this variant?
The variant rs113288717 has a reported population frequency of approximately 0.037, though frequencies can vary significantly depending on ancestral background.
Frequently asked questions
Can I use this SNP to predict my risk of cognitive decline?
No. This variant is associated with cognitive impairment in statistical studies of large groups, but it is not a diagnostic tool for individuals. Cognitive health is influenced by many factors, and a single SNP cannot provide a personal risk assessment.
What does 'intergenic' mean?
An intergenic variant is located in the DNA sequence between genes. These regions do not code for proteins, but they may play roles in regulating how nearby genes are turned on or off.
Should I be worried if I have the G/G genotype?
Genetic variants are common and do not determine your health destiny. If you have concerns about your cognitive health, you should speak with a doctor who can provide a comprehensive evaluation based on your clinical symptoms and history.
Where can I find more information on this variant?
You can search for the rsID on the GWAS Catalog or the NCBI SNP database. These resources provide access to published research and the scientific context behind genetic associations.
Sources & further reading
Educational information only, last refreshed 10/12/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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