LOC105374441 rs113608863: What Your Genotype Means
The genetic variant rs113608863 is a single nucleotide polymorphism (SNP) located within the LOC105374441 gene region. It has been identified in genome-wide association studies (GWAS) as a suggestive marker associated with facial skin sebum production and photo-aging parameters.
What each genotype means
Typical skin sebum profile
This genotype represents the common baseline for this genetic marker. Research suggests this variant is associated with facial skin sebum and oil traits, though the evidence remains limited and primarily observed in East Asian populations. This finding is a statistical association and does not indicate a specific skin condition or health outcome.
This is the most common genotype in populations where this variant is present.
Potential skin trait variation
Carrying one copy of the minor allele may be associated with subtle differences in facial skin sebum or oil production. Current evidence for this association is limited and based on GWAS findings, meaning the clinical significance is not well-established. Please note that skin health is influenced by a complex interplay of genetics, environment, and lifestyle factors.
This genotype is observed at low-to-moderate frequency, primarily within East Asian populations.
Potential skin trait variation
Carrying two copies of the minor allele may be associated with variations in facial skin sebum or oil production compared to the common genotype. Because the evidence for this association is limited, it is unclear how this genotype influences individual skin characteristics. This information is for educational purposes and should not be used to guide medical or dermatological decisions.
This genotype is less common and is primarily found in East Asian populations.
Understanding the Variant
A single nucleotide polymorphism, or SNP, is a variation at a single position in a DNA sequence among individuals. The variant rs113608863 represents a specific location in the human genome where a single base pair differs between people. This SNP is situated within the genomic region associated with the LOC105374441 gene. In genetic research, identifying such variants is the first step toward understanding how subtle differences in our DNA code might influence physical traits. While rs113608863 has been highlighted in scientific literature, it is classified as a 'suggestive' locus, meaning that while statistical signals have been observed, the biological mechanism by which this specific DNA change influences skin physiology remains an active area of investigation.
The Role of LOC105374441
The gene LOC105374441 is a locus identified through genomic mapping. In the context of skin research, scientists look for genes that may influence the function of sebaceous glands—the structures responsible for producing sebum, an oily substance that lubricates the skin. Sebum production is a complex physiological process that varies significantly between individuals based on age, sex, and genetic background. While the specific function of the LOC105374441 gene is not as extensively characterized as better-known skin genes, its proximity to the rs113608863 variant suggests it may play a role in the regulatory pathways governing skin oiliness or the skin's response to environmental stressors like ultraviolet radiation, which contributes to photo-aging.
Evidence and Associations
The association between rs113608863 and skin traits is grounded in GWAS, which scan the genomes of large groups of people to find statistical links between specific variants and physical characteristics. Research has identified this SNP as a potential marker for facial sebum traits and photo-aging parameters. It is important to note that the evidence strength for this association is currently considered limited. In scientific terms, 'suggestive' means the statistical p-values reached a threshold of interest but may not yet meet the rigorous standards required to confirm a definitive causal relationship. Because skin aging is a polygenic trait—meaning it is influenced by many genes working in concert with environmental factors like sun exposure and lifestyle—no single variant like rs113608863 can predict an individual's skin health or aging trajectory.
Population Frequency
Genetic variants often show different frequency patterns across global populations due to evolutionary history and migration. Current research indicates that rs113608863 is found at low-to-moderate frequency specifically within East Asian populations. Because many GWAS are conducted on specific ancestral groups, findings observed in one population may not necessarily replicate in others. This ancestry-specific observation highlights the importance of diversity in genomic research; understanding how a variant behaves in one group helps scientists build a more complete picture of human genetic variation. If you are interested in your own genetic profile, it is helpful to remember that population-level statistics describe groups, not individuals, and your personal genetic makeup is a unique combination of thousands of variants.
Interpreting Your Results
If you have received information about your rs113608863 genotype, it is essential to view it as a piece of scientific data rather than a medical diagnosis. This variant is not a clinical tool for predicting skin disease or determining specific skincare needs. Because the association is suggestive and the biological impact is not fully understood, this information cannot be used to guide medical decisions or treatment plans. Skin health is influenced by a vast array of factors, including diet, sun protection habits, and overall health. If you have concerns about your skin, such as changes in oil production, texture, or signs of premature aging, the most effective approach is to consult a board-certified dermatologist. They can provide evidence-based advice tailored to your specific skin type and health history.
How common is this variant?
The rs113608863 variant is observed at low-to-moderate frequency in East Asian populations, with limited data available for other global ancestral groups.
Frequently asked questions
Can this SNP predict if I will have oily skin?
No. While rs113608863 has been associated with sebum traits in research studies, it is not a diagnostic test for skin type. Oily skin is influenced by many genetic and environmental factors, and this variant alone cannot predict your skin's oil production.
Is rs113608863 a marker for skin cancer?
There is no evidence linking this specific variant to skin cancer. The research regarding this SNP is focused on skin physiology traits like sebum production and photo-aging, not disease risk.
Should I change my skincare routine based on this variant?
No. You should not alter your skincare routine based on this genetic information. Skincare should be based on your current skin condition and professional advice from a dermatologist, not on suggestive genetic markers.
Why is the evidence for this variant called 'limited'?
In genomics, 'limited' evidence means that while some studies have found a statistical association, the findings have not been consistently replicated across large, diverse populations. More research is required to confirm the biological significance of the variant.
Sources & further reading
Educational information only, last refreshed 10/10/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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