Understanding rs11652684: A Common Genetic Variant
The rs11652684 variant is a common genetic marker located in an intergenic region of the human genome. It has been identified in large-scale genome-wide association studies (GWAS) as being linked to specific phenotypic traits.
What each genotype means
Common genetic variant profile
This genotype represents the homozygous state for the A allele at this location. Current research in the GWAS Catalog indicates this variant is associated with various traits, though specific clinical implications remain under investigation and are not diagnostic of any condition.
This genotype is common in many global populations, though exact frequencies vary significantly by ancestry.
Common genetic variant profile
This genotype represents the heterozygous state for the A and G alleles at this location. Large-scale association studies have linked this variant to specific phenotypic traits, but the presence of this genotype does not indicate a medical diagnosis or specific health outcome.
This genotype is observed frequently across diverse populations, with prevalence rates dependent on regional genetic background.
Common genetic variant profile
This genotype represents the homozygous state for the G allele at this location. While this variant is cataloged in genome-wide association studies, the current evidence is limited and does not support specific clinical or health-related predictions for individuals carrying this genotype.
This genotype is found at varying frequencies globally, appearing as a common variant in many population groups.
What is rs11652684?
The rs11652684 variant is a single nucleotide polymorphism (SNP), which is a variation at a single position in the DNA sequence. In the context of human genetics, SNPs are the most common type of genetic variation. This specific variant is classified as intergenic, meaning it is located in the DNA sequence between genes rather than within a gene that codes for a protein. Because it is intergenic, it does not directly alter the structure of a protein. Instead, researchers study such variants to understand how they might influence the regulation of nearby genes or serve as markers for other functional genetic changes nearby. It is cataloged in major databases like dbSNP, which track these variations across the human population to facilitate scientific research.
Research and Associations
The rs11652684 variant is included in the GWAS Catalog, a curated collection of published genome-wide association studies. These studies compare the genomes of large groups of people to identify statistical associations between specific genetic variants and various health-related traits or conditions. When a variant like rs11652684 is identified in a GWAS, it means that individuals with a particular allele at this position are statistically more or less likely to exhibit a certain trait compared to those without it. It is important to note that these associations are statistical in nature and do not necessarily imply a direct cause-and-effect relationship. The evidence strength for this variant is currently categorized as moderate, reflecting the findings reported in large-scale population studies.
Population Frequency
The rs11652684 variant is considered a common SNP. In genetics, a variant is typically described as common if it appears with a significant frequency across the general population. Because it is common, it is found in many individuals across diverse ancestral backgrounds. Population databases like gnomAD provide data on how frequently different alleles appear in various continental populations, such as African, European, East Asian, and South Asian groups. Understanding the frequency of a variant is a fundamental step in genetic research, as it helps scientists distinguish between rare variants that might have a strong impact on health and common variants that contribute to the natural diversity of human traits.
Interpreting Genetic Information
Information about genetic variants like rs11652684 is intended for educational and research purposes. It is crucial to understand that having a specific genotype at this location does not constitute a medical diagnosis or a prediction of future health outcomes. Genetic associations identified in research studies are often based on averages across large populations and may not apply to any single individual. If you have questions about your genetic information or how it relates to your health, the most appropriate course of action is to consult with a qualified healthcare professional, such as a doctor or a genetic counselor. They can provide context based on your personal and family medical history, which is essential for interpreting any genetic data accurately.
How common is this variant?
The rs11652684 variant is a common SNP, meaning it is widely distributed across various human populations and ancestral groups.
Frequently asked questions
What does it mean if a SNP is intergenic?
An intergenic SNP is located in the DNA sequence between genes. Because it is not inside a gene, it does not change the protein produced by that gene, though it may still play a role in how genes are regulated.
Can I use this information to diagnose a disease?
No, this information cannot be used for diagnosis. Genetic associations are statistical findings from large studies and do not provide medical advice or individual health predictions.
Where can I find more information about this variant?
You can search for the rsID (rs11652684) in public databases like the GWAS Catalog or dbSNP. These resources provide detailed information on the studies and populations where the variant has been observed.
Should I be worried if I have a specific genotype for this SNP?
There is no reason for concern based on a single SNP genotype. Most common variants have a very small impact on health, and genetic results should always be discussed with a healthcare provider.
Sources & further reading
Educational information only, last refreshed 10/2/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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