FGL1 rs116936231: What Your Genotype Means
The genetic variant rs116936231 is a single nucleotide polymorphism located within the FGL1 gene. It has been identified through genome-wide association studies as being linked to physician-diagnosed food allergy and food-specific IgE sensitization in individuals of European ancestry.
What each genotype means
Typical genetic profile
This genotype represents the most common form of this variant observed in the general population. Research indicates that individuals with this genetic makeup do not carry the specific allele associated with increased susceptibility to physician-diagnosed food allergy and IgE sensitization in this study context.
Carried by the vast majority of individuals of European ancestry.
Increased allergy susceptibility marker
This genotype includes one copy of the variant allele identified in large-scale studies as being associated with a higher likelihood of physician-diagnosed food allergy and food-specific sensitization. Because this is a complex trait influenced by many genetic and environmental factors, this result does not confirm a diagnosis but suggests a statistical association that may be relevant to your health history.
Carried by roughly 1 in 10 to 1 in 20 people of European ancestry.
Elevated allergy susceptibility marker
This genotype includes two copies of the variant allele linked to an increased risk of physician-diagnosed food allergy and IgE sensitization in European cohorts. While this variant is statistically significant, food allergy is a multifactorial condition; please discuss any concerns regarding allergies or immune health with your clinician.
Carried by approximately 1 in 400 to 1 in 2,500 people of European ancestry, based on a minor allele frequency of 0.02 to 0.05.
Understanding rs116936231
A single nucleotide polymorphism, or SNP, is a variation at a single position in a DNA sequence among individuals. The variant rs116936231 represents a specific location in the human genome where one nucleotide may differ between people. This SNP is situated within the FGL1 gene, which stands for Fibrinogen Like 1. In the context of genetic research, identifying such variants helps scientists map the complex architecture of human traits and diseases. By studying where these variants sit in relation to genes, researchers can begin to hypothesize how specific DNA changes might influence biological processes. It is important to note that the presence of a specific SNP does not guarantee the development of a trait; rather, it indicates a statistical association observed in large-scale population studies.
The Role of the FGL1 Gene
The FGL1 gene encodes a protein that is structurally related to fibrinogen, a protein involved in blood clotting. However, FGL1 is primarily secreted by the liver and has been implicated in various physiological processes, including the regulation of metabolism and immune responses. While its exact role in the development of food allergies is still an area of active investigation, researchers are interested in how variations in this gene might influence the immune system's sensitivity to food proteins. Understanding the function of FGL1 provides a biological framework for why variants in this region might be statistically linked to allergic phenotypes. As research progresses, scientists aim to clarify the precise mechanisms by which FGL1 expression or function might modulate the risk of IgE-mediated allergic reactions.
Research and Evidence Strength
The association between rs116936231 and food allergy was identified through large-scale genome-wide association studies (GWAS). These studies compare the DNA of individuals with a specific condition to those without it to find genetic markers that appear more frequently in the affected group. For rs116936231, evidence suggests a link to physician-diagnosed food allergy combined with food-specific IgE sensitization, particularly in adult cohorts of European ancestry. The evidence strength for this association is currently considered moderate. This means that while the statistical signal reached genome-wide significance in specific meta-analyses, the biological impact of the variant is still being explored. Genetic associations are often complex, and food allergy itself is influenced by a combination of multiple genetic factors and environmental exposures, making it difficult to isolate the effect of a single variant.
Population Frequency
The frequency of the minor allele for rs116936231 is reported to be approximately 0.02 to 0.05 in European populations. This indicates that the variant is relatively uncommon, appearing in a small percentage of the population. Because genetic frequencies can vary significantly across different ancestral groups, these statistics are most applicable to cohorts of European descent. Researchers often look at these frequencies to understand the distribution of genetic risk factors globally. It is common for variants associated with complex traits to show different frequency patterns or even different levels of association across diverse populations, which is why ongoing research continues to expand into more varied ancestral cohorts to ensure a comprehensive understanding of human genetic diversity.
Interpreting Your Genetic Information
If you have information about your genotype for rs116936231, it is important to view it as a piece of statistical data rather than a medical diagnosis. Genetic variants associated with complex traits like food allergy provide insight into potential predispositions, but they do not determine health outcomes on their own. Environmental factors, lifestyle, and other genetic markers play significant roles in the development of allergies. You cannot use this information to diagnose yourself or to predict with certainty whether you will develop a food allergy. If you have concerns about food allergies or your immune health, the most appropriate step is to consult with a qualified healthcare professional or an allergist. They can provide clinical evaluations, diagnostic testing, and personalized advice based on your medical history and symptoms.
How common is this variant?
The minor allele frequency for rs116936231 is approximately 0.02 to 0.05 in European populations.
Frequently asked questions
Does having the rs116936231 variant mean I have a food allergy?
No, having this variant does not mean you have a food allergy. It is a statistical marker associated with an increased likelihood of the trait in large population studies, not a diagnostic test.
Can I use this genetic information to change my diet?
You should not change your diet based on this genetic information. Dietary decisions should be made in consultation with a healthcare provider or a registered dietitian, especially if you suspect an allergy.
Is this variant found in all populations?
The association for this variant has been primarily studied and reported in European ancestry cohorts. Its frequency and relevance in other ancestral populations may differ and require further research.
What should I do if I am worried about food allergies?
If you are concerned about food allergies, you should schedule an appointment with an allergist or your primary care physician. They can perform clinical tests to determine if you have an allergy.
Sources & further reading
Educational information only, last refreshed 9/30/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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