GRM8 rs117737118: What Your Genotype Means
The rs117737118 variant is a rare genetic change located within the GRM8 gene. Current research suggests this variant may be associated with variations in metabolic health and body composition.
What each genotype means
Typical metabolic profile
This is the most common genotype observed in the general population for this variant. Research indicates that this specific genetic sequence is not associated with the metabolic health variations linked to the alternative allele. No specific medical action is indicated based on this result.
This is the predominant genotype found in the vast majority of individuals across all global populations.
Potential metabolic health association
Carrying one copy of the C allele has been identified in genome-wide association studies as a marker linked to variations in metabolic health and body composition. Because this variant is rare, the clinical significance for an individual remains uncertain and should be viewed as a statistical association rather than a diagnostic finding. Please discuss any concerns regarding your metabolic health or body composition with your healthcare provider.
This genotype is rare, appearing in a very small fraction of the population according to large-scale genomic databases.
Potential metabolic health association
Carrying two copies of the C allele is associated with the same metabolic health and body composition traits identified in research for this variant. As this is a rare genotype, the specific impact on your health is not fully understood and may be influenced by other genetic and environmental factors. You should discuss your overall metabolic health profile with your clinician.
This genotype is extremely rare and is observed in a negligible percentage of the global population.
Understanding the rs117737118 Variant
The rs117737118 variant is a specific change in the human genetic code located within the GRM8 gene. In genomics, an rsID (reference SNP cluster ID) acts as a unique identifier for a specific location in the genome where a single nucleotide polymorphism (SNP) or other small variation has been observed. This particular variant is classified as rare, meaning it is found in only a very small percentage of the global population. Because it is rare, researchers often study such variants to understand how they might contribute to individual differences in health and physiology. By mapping these variations to specific locations on the chromosome, scientists can begin to investigate whether these changes influence how our bodies function at a molecular level.
The Role of the GRM8 Gene
The GRM8 gene provides instructions for making a protein called metabotropic glutamate receptor 8. This receptor is part of a family of proteins that respond to glutamate, which is the primary excitatory neurotransmitter in the human brain. By binding to glutamate, the GRM8 receptor helps regulate the transmission of signals between nerve cells, effectively acting as a chemical messenger system. Beyond its well-documented role in neurological processes, recent research has begun to explore the expression of glutamate receptors in other tissues. This has led to investigations into how the GRM8 gene might influence metabolic pathways and body composition. Understanding the function of this gene is essential for interpreting how variations within its sequence might potentially impact broader physiological traits.
Research and Evidence Strength
Current scientific evidence linking rs117737118 to metabolic health and body composition is considered moderate. Research in this field often involves large-scale studies that look for statistical correlations between specific genetic variants and measurable physical traits. While some studies have identified associations between GRM8 variants and metabolic outcomes, it is important to note that these findings are often based on complex statistical models. Because metabolic health is influenced by a combination of many genes, environmental factors, and lifestyle choices, the effect of a single rare variant like rs117737118 is typically small. Consequently, while the association is a subject of ongoing scientific interest, it does not imply a direct cause-and-effect relationship for any individual. Further research is required to fully understand the biological mechanisms involved.
Population Frequency
The rs117737118 variant is categorized as rare across most human populations. In large-scale genomic databases, the frequency of this variant is very low, meaning that the vast majority of people carry the common, or reference, version of the gene at this position. Because the variant is rare, it is difficult to draw broad conclusions about its distribution across different ancestral groups. Genomic databases like gnomAD provide valuable data on how often these variants appear, but for rare markers, the sample sizes for specific populations may be limited. This rarity is a common feature of many variants currently being studied in the context of complex traits, highlighting the need for continued, diverse genetic research to ensure findings are applicable to all populations.
Interpreting Your Genetic Information
If you have received information about your status for the rs117737118 variant, it is important to view this in the context of your overall health. Genetic variants are only one piece of a much larger puzzle that includes your diet, physical activity, and medical history. This information is intended for educational purposes and should not be used to make medical decisions or to diagnose any condition. If you are concerned about your metabolic health or body composition, the most effective approach is to consult with a qualified healthcare provider or a registered dietitian. They can help you interpret your health data in a meaningful way and provide personalized guidance based on your specific needs. Never use genetic data to alter your medical treatment or lifestyle without professional clinical advice.
How common is this variant?
The rs117737118 variant is rare, with an allele frequency typically well below 0.1% in most global populations represented in genomic databases.
Frequently asked questions
What does it mean if I have the rs117737118 variant?
Having this variant simply means you carry a specific, rare genetic change in the GRM8 gene. It does not mean you have a disease or a specific health condition, as genetic associations are complex and influenced by many other factors.
Can I use this information to change my diet?
You should not use genetic information to make significant changes to your diet or lifestyle without consulting a healthcare professional. A doctor or registered dietitian can provide advice tailored to your overall health status.
Is this variant linked to a specific disease?
Current research associates this variant with variations in metabolic health and body composition, but it is not considered a diagnostic marker for any specific disease. These associations are based on statistical trends in large populations.
Where can I find more information about GRM8?
You can find detailed information about the GRM8 gene and its functions on the National Center for Biotechnology Information (NCBI) Gene database. It provides comprehensive summaries of gene function and related research.
Sources & further reading
Educational information only, last refreshed 9/16/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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This SNP is linked to metabolic phenotypes that may indirectly affect physical appearance traits.
This variant in the GRM8 gene has been identified through GWAS as having a potential association with metabolic traits that can influence overall physical constitution.