rs11799152: Y-DNA Haplogroup G Marker Explained
rs11799152 is a single-nucleotide polymorphism located on the non-recombining portion of the human Y chromosome, also recognized in phylogenetic literature by designations such as U3 or PF2956. Rather than contributing to disease risk or clinical traits, this variant functions as an ancestral lineage marker that defines paternal branches within Y-chromosome haplogroup G. Because it sits on the Y chromosome, it is inherited strictly along patrilineal lines and reflects ancient human population movements.
What each genotype means
Ancestral Y-chromosome lineage
This genotype represents the ancestral state for this marker, meaning you do not carry the specific mutation that defines the U3 or PF2956 sub-branch of haplogroup G. This result indicates your paternal lineage belongs to a broader ancestral group rather than this specific derived branch.
This is the ancestral allele and is found in the majority of the global population outside of the specific haplogroup G lineages where the derived G allele is present.
Derived Y-chromosome lineage
This genotype indicates you carry the derived allele associated with the U3 or PF2956 sub-branch of Y-chromosome haplogroup G. Because this is a Y-chromosome marker, this result is specific to paternal ancestry and reflects a shared genetic history with other men in this lineage.
This genotype is observed in populations where haplogroup G lineages are present, with a global minor allele frequency of approximately 1.3%.
Derived Y-chromosome lineage
This genotype indicates you carry the derived allele associated with the U3 or PF2956 sub-branch of Y-chromosome haplogroup G. This marker is used in genealogical research to help define specific ancestral sub-branches within the broader haplogroup G phylogeny.
This genotype is observed in populations where haplogroup G lineages are present, with a global minor allele frequency of approximately 1.3%.
Genomic Location and Variant Classification
The genetic variant rs11799152 is located on the male-specific region of chromosome Y (positioned at 12,881,443 on GRCh38). Unlike variants positioned within protein-coding regions, rs11799152 is intergenic and does not fall within or alter any identified functional gene. The variant represents a binary single-nucleotide transition from an ancestral adenine (A) allele to a derived guanine (G) allele. Because this region of the Y chromosome does not undergo standard homologous crossing over during meiosis, mutations that arise here are preserved across generations. In phylogenetic research, including phylogenetic catalogs maintained by the International Society of Genetic Genealogy, this variant is also tracked under alternative names such as PF2956 and U3. Its primary utility lies in molecular anthropology, genetic genealogy, and phylogenetics rather than clinical genetics or pharmacology.
Biological Role and Ancestral Significance
Because rs11799152 is situated in an intergenic region of the Y chromosome, it does not transcribe a messenger RNA or alter the sequence of an encoded protein. Consequently, there are no direct biological or physiological phenotypes linked to its different alleles. Instead, the mutation serves as a phylogeographic milestone. Within the human paternal family tree, haplogroup G represents a distinct lineage that diversified tens of thousands of years ago in western Asia and the Near East. Variants such as rs11799152 act as stable molecular clocks. Once the derived G allele emerged on an ancestral Y chromosome, it was stably passed down exclusively from father to son. Modern population geneticists use these stable single-nucleotide changes to reconstruct historical migration routes, founder events, and ancient demographic shifts across western Eurasia without confounding effects from biological selection.
Research Associations and Clinical Relevance
Extensive screening across databases including ClinVar, the GWAS Catalog, and PharmGKB reveals no established clinical, pathological, or pharmacological associations for rs11799152. Its characterization in the scientific literature is confined strictly to population genetics and phylogeography, such as studies investigating human paternal phylogeny and haplogroup G structure. In genome-wide association studies, rs11799152 has not demonstrated reproducible links to complex illnesses, quantitative traits, or drug efficacy. Any classification in consumer genomic catalogs under the category of 'Trait' is nominal, reflecting patrilineal descent classification rather than a noticeable physical characteristic or health risk. The scientific consensus regards rs11799152 entirely as a neutral ancestral marker, meaning that having the derived or ancestral allele provides no indication of disease predisposition or biological dysfunction.
Understanding Your Test Result
Discovering an rs11799152 genotype on an ancestry or direct-to-consumer genetic test informs a user strictly about direct paternal lineage. Individuals with two X chromosomes do not carry a Y chromosome and therefore will typically lack data for rs11799152 or show a no-call on microarrays. For individuals with a Y chromosome, carrying the derived G allele indicates membership in a specific branch of paternal haplogroup G, while the ancestral A allele indicates another branch of the human paternal phylogenetic tree. This result cannot predict personal health outcomes, physical appearance, or fitness, nor does it represent your entire genealogical ancestry, as the Y chromosome reflects only a single ancestral line out of thousands across human history. No clinical action, medical screening, or lifestyle modification is warranted based on your rs11799152 genotype.
How common is this variant?
Globally, the derived G allele is relatively uncommon with an estimated frequency of approximately 1.3%, but it is enriched in populations containing paternal haplogroup G lineages across the Caucasus, the Near East, and Southern Europe.
Frequently asked questions
Does the rs11799152 variant cause any health problems?
No, rs11799152 has no known association with disease, health disorders, or medical vulnerabilities. It is an intergenic variant on the Y chromosome used strictly as a population genetics and ancestry marker.
Why do some people show no data for rs11799152?
Because rs11799152 is located on the male-specific region of the Y chromosome, individuals who do not possess a Y chromosome (such as genetic females with XX chromosomes) will not carry this genetic locus.
What does haplogroup G indicate about my ancestry?
Haplogroup G is a major paternal lineage that originated in the Near East or Caucasus region and expanded into Europe during ancient agricultural migrations. Carrying a marker for this group connects your direct patrilineal lineage to those historical populations.
Can rs11799152 affect how my body processes medications?
No, rs11799152 is not involved in drug metabolism and has no entry in pharmacogenomic resources like PharmGKB or CPIC. It has no bearing on medication efficacy or dosing.
Sources & further reading
Educational information only, last refreshed 9/7/2026. Not medical advice — these associations describe population statistics, not individual predictions.
Curious what your genotype is for rs11799152?
Upload a raw DNA file from 23andMe, AncestryDNA, MyHeritage, or FamilyTreeDNA and see this variant — plus thousands more — interpreted in your full report.
Get my report — $29Related variants in Y-Chromosome
This Y-chromosome SNP is used to distinguish haplogroup G phylogeny.
A phylogenetic marker defining human paternal Y-chromosome Haplogroup P.
An ancestral informative lineage marker defining sub-lineages within Y-haplogroup R1a.
A Y-chromosome haplogroup-defining ancestral single nucleotide polymorphism (M35.1) key for mapping North and East African paternal heritage.