PRLHR rs118594083: Understanding This Genetic Variant
The rs118594083 variant is a specific genetic change located in the 3' untranslated region (UTR) of the PRLHR gene. This gene is responsible for encoding a receptor that plays a role in regulating reproductive hormones and metabolic processes like food intake.
What each genotype means
Typical genetic profile
This genotype represents the most common sequence observed at this location in the PRLHR gene. Current scientific literature does not associate this specific sequence with any known clinical conditions or reproductive health outcomes. As research on this variant is limited, its functional impact remains unknown.
This is the most frequent genotype observed across global populations.
Rare genetic variation
You carry one copy of the less common allele at this position in the PRLHR gene. There is currently no established clinical evidence linking this specific variation to reproductive hormone regulation or other health traits. Because this variant is rare and evidence is limited, the functional significance of this genotype is not well understood.
This genotype is extremely rare, appearing in a very small fraction of the global population.
Rare genetic variation
You carry two copies of the less common allele at this position in the PRLHR gene. Scientific research has not yet determined if this specific genotype influences the function of the prolactin-releasing hormone receptor or related physiological processes. Due to the limited nature of current data, this finding should be considered of unknown clinical significance.
This genotype is exceptionally rare and is not commonly observed in standard population genetic studies.
What is the rs118594083 Variant?
The rs118594083 variant is a single nucleotide polymorphism (SNP) situated within the 3' untranslated region (3' UTR) of the PRLHR gene. The 3' UTR is a segment of messenger RNA that follows the coding region of a gene; while it does not provide instructions for building a protein, it is critical for regulating how much protein is produced and how stable the genetic message remains within the cell. Because this variant is located in a regulatory region rather than the protein-coding sequence, its primary potential impact is on the fine-tuning of gene expression rather than altering the structure of the receptor protein itself. Geneticists study these non-coding variants to understand how subtle changes in gene regulation can influence complex biological pathways.
The Role of the PRLHR Gene
The PRLHR gene encodes the prolactin-releasing hormone receptor, also known as GPR10. This receptor is a member of the G-protein-coupled receptor family, which acts as a molecular switch on the surface of cells to transmit signals from the outside environment to the cell's interior. Research indicates that the PRLHR receptor is involved in several physiological functions, including the regulation of food intake, energy balance, and reproductive hormone signaling. By binding to specific neuropeptides, the receptor helps the body respond to metabolic cues. Because of its involvement in these pathways, the gene is a subject of interest in studies concerning appetite regulation and metabolic health, though its exact contribution to human disease remains a topic of ongoing scientific investigation.
Evidence and Associations
Current evidence regarding the clinical significance of rs118594083 is limited. While the PRLHR gene itself is well-characterized in biological research for its role in hormone signaling and feeding behavior, specific associations between the rs118594083 variant and human health outcomes are not well-established in large-scale clinical studies. In genomics, a 'limited' evidence strength means that while the variant exists and is cataloged, there is currently insufficient data to conclude that it causes or significantly contributes to any specific medical condition. It is common for many variants in the non-coding regions of the genome to have neutral effects. Researchers continue to monitor such variants as more data becomes available through global genomic databases, but at this time, this variant should not be considered a diagnostic marker for any health condition.
Population Frequency
The population frequency of rs118594083 is not widely documented in major public databases, and specific data regarding its prevalence across different ancestral groups is currently thin. In genomic research, when a variant is not frequently reported in large cohorts like gnomAD, it may indicate that the variant is rare or that it has not been a primary focus of large-scale population studies. Because frequency data is currently unavailable, it is impossible to determine if this variant is common or rare in the general population. As more individuals participate in genomic research, our understanding of the distribution of such variants will improve, providing a clearer picture of how common this specific genetic change is globally.
What You Can Do With This Information
Information about variants like rs118594083 is primarily educational and intended to help the public understand the complexity of the human genome. Because the evidence for this variant is limited and there are no established clinical associations, this information does not have a direct application in medical decision-making or personal health management. You cannot use this information to diagnose a condition or predict a health outcome. If you have received this information through a genetic test and have concerns about your health, metabolic function, or reproductive history, the most appropriate step is to consult with a qualified healthcare provider or a genetic counselor. They can help you interpret your overall health profile in the context of your medical history and current clinical guidelines, rather than focusing on a single, unverified genetic variant.
How common is this variant?
The population frequency for rs118594083 is not currently specified in major genomic databases, suggesting that data on its prevalence across different ancestries is limited.
Frequently asked questions
Is rs118594083 associated with weight gain?
While the PRLHR gene is involved in feeding behavior and metabolism, there is no established scientific evidence linking the rs118594083 variant to weight gain or obesity in humans.
Should I be worried if I have this variant?
No. The evidence for this variant is limited, and it is not currently linked to any known health risks. It is common to carry many genetic variations that have no impact on your health.
Can I use this to change my diet?
No. This variant does not provide actionable information for dietary changes. Always consult with a registered dietitian or your doctor before making significant changes to your nutrition plan.
Where can I find more information about PRLHR?
You can find reliable information about the PRLHR gene on resources like the NCBI Gene database or the GeneCards website, which provide summaries of gene function and research.
Sources & further reading
Educational information only, last refreshed 9/19/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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