rs13007553: Understanding Genetic Associations with CAD Mortality
The rs13007553 variant is a common genetic marker located in an intergenic region of the human genome. Research has identified a statistical association between this variant and an increased risk of all-cause mortality in individuals already diagnosed with coronary artery disease.
What each genotype means
Baseline mortality risk
This genotype represents the major allele pair for this variant. Research indicates that individuals with this genotype do not carry the additional mortality risk associated with the T allele in patients with coronary artery disease.
This is the most common genotype for this variant in populations of European ancestry.
Increased mortality risk
Carrying one copy of the T allele is associated with a statistically significant increase in the risk of all-cause mortality for individuals already diagnosed with coronary artery disease. If you have this genotype and a history of heart disease, please discuss your long-term health management and risk factors with your cardiologist.
This genotype is found in a significant portion of the population, though it is less common than the homozygous CC genotype.
Elevated mortality risk
Carrying two copies of the T allele is associated with a higher statistical risk of all-cause mortality in patients with coronary artery disease compared to those without the T allele. This association has been observed in clinical studies of White patients with coronary artery disease; please consult your healthcare provider to discuss your specific cardiovascular health profile.
This is the least common genotype for this variant in most studied populations.
What is rs13007553?
The rs13007553 variant is a single-nucleotide polymorphism (SNP), which is a variation at a single position in the DNA sequence. This specific SNP is classified as intergenic, meaning it is located in the non-coding DNA sequence between genes rather than within a gene that codes for a protein. Specifically, rs13007553 is situated between the MYTIL and EIPR1 genes. Because it resides in a non-coding region, its biological function is not immediately obvious, and it does not directly alter a protein sequence. Instead, researchers study such variants to determine if they influence how nearby genes are regulated or expressed. In the context of genomic research, rs13007553 is identified by its unique reference SNP ID (rsID) assigned by the dbSNP database, which allows scientists to track and compare findings across different studies globally.
Research and Clinical Associations
The primary evidence for rs13007553 comes from genome-wide association studies (GWAS) focused on longitudinal survival outcomes in patients with coronary artery disease (CAD). A study published in Frontiers in Genetics identified this variant as having a significant association with all-cause mortality in White patients with CAD. In this research, the minor T allele was associated with a 53% increased risk of mortality per copy, even after adjusting for various clinical covariates. It is important to note that this evidence is based on statistical associations observed in specific cohorts. While the association was consistent across discovery, replication, and meta-analysis phases in the cited study, it represents a correlation rather than a direct cause-and-effect mechanism. The strength of this evidence is considered moderate, as it highlights a potential genetic contributor to disease progression that warrants further investigation into the underlying biological pathways.
Understanding Your Results
If you encounter this variant in a genetic report, it is essential to understand that this information is for educational purposes and does not constitute a medical diagnosis. Genetic variants like rs13007553 are just one of many factors—including lifestyle, environment, and other genetic markers—that contribute to overall health outcomes. Having a specific genotype does not guarantee a particular health outcome, nor does it provide a definitive prediction of survival. Because this variant is associated with mortality risk specifically in the context of existing coronary artery disease, it is not a standalone tool for assessing general health. If you have concerns about your cardiovascular health or how your genetic profile might relate to your medical history, you should discuss these findings with a qualified healthcare provider or a cardiologist who can interpret them within the context of your complete clinical picture.
How common is this variant?
The rs13007553 variant is considered a common SNP, meaning it appears frequently across various populations with a minor allele frequency typically greater than 0.05.
Frequently asked questions
Does having the rs13007553 T allele mean I will develop heart disease?
No. The association identified in research is specific to mortality risk in individuals who have already been diagnosed with coronary artery disease. It is not a diagnostic marker for the development of heart disease itself.
Can I change my risk associated with this variant?
Genetic variants are inherited and cannot be changed. However, managing cardiovascular health through lifestyle choices, such as diet, exercise, and clinical management of blood pressure and cholesterol, remains the primary way to influence heart health outcomes.
Is this variant used in clinical practice?
Currently, rs13007553 is primarily a subject of research. It is not routinely used in clinical settings to guide treatment decisions or predict individual patient outcomes.
Where can I find more information about this SNP?
You can search for the rsID on public databases like the NCBI dbSNP website or the GWAS Catalog. These resources provide technical details and links to the original scientific publications.
Sources & further reading
Educational information only, last refreshed 10/28/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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