rs138174682: Investigating Genetic Links to Human Longevity
The variant rs138174682 is a rare genetic change located in an intergenic region of the human genome. It is currently being investigated by researchers for its potential association with extreme human longevity.
What each genotype means
Typical genetic profile
This genotype represents the most common form of this genetic location observed in the general population. Current research into this specific variant is ongoing, and there is no established evidence that this genotype significantly influences longevity or other health traits. As this is an intergenic variant, it does not directly alter protein-coding sequences.
This is the most frequent genotype found across all major global populations.
Rare variant carrier
You carry one copy of a rare genetic variant that is currently being investigated for its potential association with extreme longevity. Because this variant is rare and located in an intergenic region, its functional impact remains uncertain and is not considered a diagnostic indicator of health or lifespan. Scientific understanding of this variant is still evolving as more data from diverse populations becomes available.
This genotype is rare and observed at very low frequencies across most studied ethnic groups.
Rare variant homozygous
You carry two copies of a rare genetic variant that is currently under study for its potential role in human longevity. The scientific evidence regarding this variant is limited, and it is not currently possible to determine if this genotype confers any specific biological advantage or risk. Further research is required to understand the significance of this variant in the context of aging and health.
This genotype is extremely rare and is found in only a tiny fraction of the global population.
Understanding the Variant
The variant rs138174682 is a single nucleotide polymorphism (SNP), which is a variation at a single position in the DNA sequence. This specific SNP is classified as intergenic, meaning it is located in the non-coding DNA between genes rather than within a gene that provides instructions for making proteins. Because it does not sit inside a known gene, researchers are interested in whether it might influence the regulation of nearby genes or play a role in complex biological pathways. In the context of human genetics, intergenic variants are often studied to see if they act as switches or enhancers that modulate how genes are expressed throughout a person's life. While many intergenic variants have no known effect, others are found to be statistically linked to specific traits or health outcomes through genome-wide association studies.
The Science of Longevity
Human longevity is a complex, polygenic trait, meaning it is influenced by the combined effects of many different genetic variants, as well as environmental and lifestyle factors. Research into extreme longevity often focuses on centenarians—individuals who have reached the age of 100 or older—to identify genetic signatures that may contribute to their survival. While well-known genes like APOE and FOXO3A have been consistently linked to aging and lifespan in various studies, the genetic architecture of longevity remains largely elusive. Scientists use large-scale genomic data to look for rare variants that might be enriched in long-lived populations. The investigation into rs138174682 is part of this broader effort to map the rare genetic landscape that might protect against age-related decline or promote healthy aging processes, though evidence for this specific variant remains moderate and requires further validation.
Evidence and Uncertainty
The evidence linking rs138174682 to longevity is currently classified as moderate. In genetic research, a moderate evidence strength suggests that while there are observed statistical associations in certain cohorts, these findings have not yet reached the level of definitive proof required to establish a clear biological mechanism. It is important to note that association does not equal causation; a statistical link between a variant and a trait does not necessarily mean the variant itself causes the trait. Furthermore, genetic associations can be highly ancestry-specific, meaning a variant that appears linked to longevity in one population may not show the same effect in another. Because this variant is rare, it is difficult to gather enough data to confirm its impact across diverse groups. Researchers continue to study such variants to determine if they are truly functional or if they are simply markers inherited alongside other, more influential genetic factors.
What This Information Means for You
If you have encountered information about rs138174682, it is essential to view it as a subject of ongoing scientific inquiry rather than a diagnostic tool. Because the role of this variant in human health is not fully understood, it cannot be used to predict your lifespan or health outcomes. Genetic testing for such rare variants is not a standard clinical practice and does not provide actionable medical advice. Longevity is heavily influenced by factors you can control, such as diet, physical activity, sleep, and regular medical screenings. If you are interested in your genetic health, the best approach is to consult with a certified genetic counselor or a healthcare provider who can help you interpret information in the context of your personal and family medical history. Always prioritize evidence-based lifestyle choices over the results of individual genetic markers, which currently offer only a very small piece of a much larger, complex puzzle.
How common is this variant?
The variant rs138174682 is considered rare across most global populations, with its specific frequency varying significantly depending on ancestral background.
Frequently asked questions
Can I use this variant to predict how long I will live?
No. Longevity is a complex trait influenced by thousands of genetic variants, environmental factors, and lifestyle choices. A single rare variant like rs138174682 cannot provide a meaningful prediction of your lifespan.
Is rs138174682 a disease-causing mutation?
There is no evidence that this variant causes disease. It is being studied for its potential association with longevity, which is a complex trait rather than a specific medical condition.
Where can I find more information about my own genetic data?
If you have had genetic testing, you should discuss your results with a qualified healthcare provider or a genetic counselor. They can help you understand the clinical relevance of any findings in the context of your health.
Why is the evidence for this variant considered moderate?
Evidence is considered moderate because while some studies have identified a statistical association, these findings have not been consistently replicated across large, diverse populations. Further research is needed to confirm the role of this variant.
Sources & further reading
Educational information only, last refreshed 9/17/2026. Not medical advice — these associations describe population statistics, not individual predictions.
Curious what your genotype is for rs138174682?
Upload a raw DNA file from 23andMe, AncestryDNA, MyHeritage, or FamilyTreeDNA and see this variant — plus thousands more — interpreted in your full report.
Get my report — $29Related variants
Nonsense change in PAX6 leading to haploinsufficiency and classical congenital aniridia.
Classic Pro23His (p.P23H) mutation in rhodopsin causing autosomal dominant retinitis pigmentosa.
Functional missense variant (p.Arg419Gln) in OCA2 modulating melanin deposition in iris and hair.
Pathogenic missense variant (p.Gly1961Glu) in ABCA4 causing Stargardt disease and macular degeneration phenotypes.
Variant in CDKN2B-AS1 strongly associated with optic nerve cup-to-disc ratio and primary open-angle glaucoma susceptibility.
Missense mutation in BEST1 causing classical Best vitelliform macular dystrophy type 2.