NTM Gene Variant rs139945292: What Your Genotype Means
The rs139945292 variant is a genetic marker located within the NTM gene. It has been identified in research as being associated with variations in blood pressure response and cardiovascular outcomes in patients treated with beta-blocker medications.
What each genotype means
Typical beta-blocker response
This genotype represents the most common genetic state for this variant. Research suggests that individuals with this profile do not carry the specific genetic marker associated with altered blood pressure response to beta-blocker therapy. Please discuss any concerns regarding your medication efficacy or cardiovascular health with your clinician or pharmacist.
This is the most common genotype observed across most global populations.
Potential altered drug response
This genotype includes one copy of the variant associated with reduced blood pressure response and increased risk of adverse cardiovascular outcomes in patients treated with beta-blockers. Because this is a statistical association, it does not guarantee a specific clinical outcome for you. Please consult your healthcare provider or pharmacist before making any changes to your prescribed medication regimen.
This genotype is considered rare, with frequency varying significantly by ancestral background.
Increased risk of adverse response
This genotype carries two copies of the variant associated with a reduced blood pressure response and a higher risk of adverse cardiovascular outcomes when using beta-blockers. These findings are based on population-level research and should be interpreted in the context of your overall health history. Always discuss your medication management and any potential side effects with your prescribing physician or pharmacist.
This genotype is rare and is found at very low frequencies in most studied populations.
Understanding the rs139945292 Variant
The rs139945292 variant is a specific single nucleotide polymorphism (SNP) located within the NTM gene on chromosome 11. In genomics, a SNP represents a variation at a single position in the DNA sequence among individuals. This particular variant is categorized as a trait-associated marker, meaning that researchers have observed statistical correlations between the presence of this specific DNA change and certain physiological or clinical outcomes. Because it is located within the NTM gene, scientists investigate whether this variant might influence how the gene functions or how it is regulated within the body. Genetic variants like rs139945292 are often identified through genome-wide association studies (GWAS), which scan the entire genome to find links between specific genetic locations and observable traits or drug responses.
The Role of the NTM Gene
The NTM gene encodes a protein called Neurotrimin, which is a member of the immunoglobulin superfamily and the IgLON family of proteins. Neurotrimin is primarily known for its role in the nervous system, where it is involved in processes such as neurite outgrowth and cell adhesion, which are critical for the development and maintenance of neural connections. Beyond its neurological functions, recent research has explored the expression of NTM in other tissues and its potential involvement in cardiovascular health. Some studies suggest that NTM may interact with various biological pathways that influence blood pressure regulation and cardiovascular disease risk. While the exact mechanism by which NTM variants influence drug response is still being studied, its role as a cell-adhesion molecule makes it a subject of interest for understanding how genetic background can influence complex physiological responses to medical treatments.
Research and Evidence Strength
The evidence linking rs139945292 to clinical outcomes is currently considered moderate. Research, including studies from the International Consortium for Antihypertensive Pharmacogenomics Studies, has highlighted that variation in the NTM gene is associated with an increased risk of adverse cardiovascular outcomes and a reduced blood pressure response in patients treated with beta-blockers. Beta-blockers are a common class of medication used to manage high blood pressure and heart conditions. When a patient carries a variant that alters their response to these drugs, it may lead to differences in how effectively the medication lowers blood pressure. It is important to note that these findings are based on statistical associations observed in large study populations. These associations do not imply a direct cause-and-effect relationship for every individual, and the strength of the evidence can vary depending on the ancestry and clinical characteristics of the populations studied.
Population Frequency and Interpretation
The rs139945292 variant is classified as rare in the general population. In genetic research, the frequency of a variant can differ significantly across various ancestral groups, which is why scientists emphasize the need for diverse study cohorts to fully understand the impact of such markers. Because this variant is rare, it is not commonly found in the general public, and its clinical significance is primarily relevant in the context of specific pharmacogenomic studies. When interpreting information about this variant, it is essential to understand that genetic markers are only one piece of a much larger puzzle. Factors such as diet, lifestyle, overall health, and other genetic variants all contribute to an individual's cardiovascular health and their response to medications. Genetic data should never be used in isolation to make health decisions.
What You Can Do With This Information
If you have received information about your status for the rs139945292 variant, it is important to approach it with a clear understanding of its limitations. This information is intended for educational purposes and does not constitute a medical diagnosis or a recommendation for treatment. Because this variant is associated with medication response, the most appropriate step is to discuss your genetic findings with your healthcare provider or a clinical pharmacist. They can help you interpret these results in the context of your personal medical history, current medications, and overall health goals. Never make changes to your prescribed medication regimen, such as stopping or altering the dose of a beta-blocker, based on genetic test results without consulting your doctor. Your clinician is the best resource for determining if any adjustments to your care plan are necessary based on your unique genetic and clinical profile.
How common is this variant?
The rs139945292 variant is considered rare across most global populations, with specific frequency data varying by ancestry.
Frequently asked questions
What is the NTM gene?
The NTM gene provides instructions for making a protein called Neurotrimin. It is primarily involved in the development of the nervous system but is also being studied for its potential role in cardiovascular health.
Does this variant mean I will have heart problems?
No. Having a specific genetic variant does not mean you will develop a disease. It simply indicates a statistical association observed in research studies that may influence how your body responds to certain medications.
Should I stop taking my beta-blocker if I have this variant?
Absolutely not. You should never stop or change your medication without consulting your doctor. Genetic variants are only one factor in how a drug works, and your doctor needs to manage your treatment based on your full clinical picture.
How can I find out if I have this variant?
This variant is typically identified through specialized genetic testing or research-grade sequencing. If you are concerned about your medication response, speak with your healthcare provider about whether pharmacogenomic testing is appropriate for you.
Sources & further reading
Educational information only, last refreshed 10/31/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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