ARRB1 rs140226575: what the research says
This low-frequency variant (Thr370Met) is associated with a greater reduction in HbA1c levels when treated with GLP-1 receptor agonists.
What each genotype means
Typical medication response
This is the common genotype for this variant. Research suggests that individuals with the alternative T allele may experience a greater reduction in HbA1c when using GLP-1 receptor agonists, but this does not imply that those with the CC genotype will not respond to treatment. Please discuss your diabetes management and medication options with your doctor.
This is the most common genotype in most populations.
Enhanced medication response
This genotype (also known as the Thr370Met variant) is associated with a greater reduction in HbA1c levels when treated with GLP-1 receptor agonists. While this may suggest a more favorable response, individual results can vary based on many factors. Please consult your healthcare provider to discuss how this might relate to your treatment plan.
This genotype is found in approximately 6-11% of Hispanic and American Indian populations.
Enhanced medication response
This genotype (also known as the Thr370Met variant) is associated with a greater reduction in HbA1c levels when treated with GLP-1 receptor agonists. While this may suggest a more favorable response, individual results can vary based on many factors. Please consult your healthcare provider to discuss how this might relate to your treatment plan.
This genotype is rare, occurring at low frequencies in Hispanic and American Indian populations.
6-11% in Hispanic and American Indian populations
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