LOC105369611 rs143070873: What Your Genotype Means
The genetic variant rs143070873 is located within the LOC105369611 gene on chromosome 12. Research has identified a statistically significant association between this variant and the plasma levels of 9-HODE, an oxylipin derived from linoleic acid.
What each genotype means
Typical oxylipin levels
This genotype is associated with baseline levels of 9-HODE, an inflammatory biomarker derived from linoleic acid. Research suggests that individuals without the T allele typically show lower levels of this specific oxylipin compared to T-allele carriers.
This is the more common genotype in many populations.
Elevated oxylipin levels
Carrying one copy of the T allele is associated with higher plasma levels of 9-HODE. This biomarker is involved in inflammatory pathways, though the clinical significance of these specific genetic-driven variations in healthy individuals remains an area of ongoing research.
This genotype is less common, occurring in approximately 5% of certain studied populations.
Higher oxylipin levels
Individuals with this genotype show a stronger statistical association with elevated levels of 9-HODE. Because 9-HODE is linked to inflammatory processes, these findings are being studied to better understand metabolic and inflammatory health, though they do not indicate a specific disease state.
This genotype is rare in most populations.
Understanding the Variant
The single nucleotide polymorphism (SNP) known as rs143070873 is a specific variation in the human genome located within the LOC105369611 gene on chromosome 12. In genetics, a SNP represents a change in a single building block of DNA, known as a nucleotide. While most of these variations have no observable effect on health, some are identified through genome-wide association studies (GWAS) because they correlate with specific biological markers. This particular variant has gained attention in the field of nutrigenomics due to its link to lipid metabolism. It is important to note that identifying a SNP is a matter of statistical probability rather than a direct cause-and-effect relationship. Researchers use these findings to better understand the complex pathways that govern how our bodies process nutrients and inflammatory biomarkers, which may eventually help in tailoring nutritional strategies to individual genetic profiles.
Association with Oxylipins
Current research, including studies conducted on pediatric cohorts, has linked the T allele of rs143070873 to higher levels of 9-HODE. 9-HODE is an oxylipin, a type of signaling molecule derived from the oxidation of linoleic acid, which is an omega-6 fatty acid. The association reached genome-wide significance in a study of children at risk for type 1 diabetes, suggesting that this genetic locus plays a role in the metabolic pathways of fatty acids. Oxylipins are often studied for their roles in inflammation and metabolic health. While the statistical evidence for this association is strong within the studied population, it is essential to recognize that these findings are based on specific cohorts. Further research across diverse populations is necessary to determine if this association holds true globally or if it is influenced by other environmental or genetic factors.
Interpreting Your Results
If you have information about your genotype for rs143070873, it is important to understand that this data is for educational purposes only. Genetic associations are not diagnostic tools and cannot predict individual health outcomes or disease risk. The presence of a specific allele does not mean you will have high or low levels of 9-HODE, as many factors—including diet, lifestyle, and other genetic variants—influence these levels. You cannot use this information to make medical decisions or to diagnose a condition. If you are concerned about your metabolic health or nutritional status, the most appropriate step is to consult with a qualified healthcare provider or a registered dietitian. They can evaluate your overall health, medical history, and lifestyle to provide personalized guidance that is far more comprehensive than any single genetic marker.
How common is this variant?
The minor allele frequency for rs143070873 is approximately 0.05, though frequencies can vary significantly depending on ancestral background.
Frequently asked questions
What is 9-HODE?
9-HODE is an oxylipin, which is a bioactive molecule produced when linoleic acid, an omega-6 fatty acid, is oxidized. These molecules are involved in various biological processes, including the regulation of inflammation.
Does this variant cause disease?
No, rs143070873 is not a disease-causing mutation. It is a genetic variant associated with variations in the levels of a specific biomarker, which is a normal part of human genetic diversity.
Can I change my genotype?
No, your genotype is determined at conception and cannot be changed. However, understanding your genetic predispositions can sometimes help you make informed lifestyle choices in consultation with a professional.
Should I change my diet based on this SNP?
You should not make dietary changes based solely on this genetic variant. Always consult with a healthcare professional or registered dietitian before making significant changes to your diet or nutrition plan.
Sources & further reading
Educational information only, last refreshed 11/6/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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