PALLD rs144493374: What Your Genotype Means
The rs144493374 variant is a specific change in the PALLD gene that has been identified in genome-wide association studies. It is currently recognized for its statistical association with variations in trunk fat mass.
What each genotype means
Typical PALLD profile
This is the most common genotype for this variant in the general population. Research indicates this version of the PALLD gene is associated with baseline levels of trunk fat mass, though individual body composition is influenced by many genetic and environmental factors.
This is the major homozygous genotype found in the vast majority of individuals across all global populations.
Associated with trunk fat
Carrying one copy of the T allele has been identified in genome-wide association studies as having a statistical link to variations in trunk fat mass. Because this association is based on population-level data, it does not predict an individual's specific body composition or health outcomes.
This heterozygous genotype is rare, occurring at low frequencies in most populations.
Associated with trunk fat
Carrying two copies of the T allele is associated with differences in trunk fat mass in some research cohorts. As this is a complex trait influenced by numerous genes and lifestyle factors, this genotype should be viewed as one small contributor to overall body composition rather than a definitive indicator.
This homozygous genotype is very rare and is observed infrequently in global population databases.
Understanding the rs144493374 Variant
The rs144493374 variant is a single nucleotide polymorphism (SNP) located within the PALLD gene. In genetics, a SNP represents a variation at a single position in the DNA sequence among individuals. This specific variant is cataloged in international databases that track genetic markers linked to human traits. Because it is classified as a rare variant, it is not found in the majority of the population, making it a subject of interest for researchers studying the genetic architecture of body composition. By mapping this variant to its precise location on the chromosome, scientists can investigate how such small changes in the genetic code might influence biological processes related to fat distribution and storage.
The Role of the PALLD Gene
The PALLD gene encodes a protein known as palladin, which is a cytoskeletal-associated protein. Palladin plays a critical role in maintaining the structural integrity of cells by acting as a component of actin-containing microfilaments. These structures are essential for controlling cell shape, adhesion, and contraction. Beyond its structural duties, research has linked the PALLD gene to various biological functions, including cell motility and tissue development. Because the cytoskeleton is fundamental to how cells interact with their environment, variations in the PALLD gene are often studied in the context of how they might influence cellular behavior. While its primary role is structural, its involvement in complex biological pathways makes it a candidate gene for studies exploring how genetic differences contribute to physical traits.
Research Associations and Evidence
The association between rs144493374 and trunk fat mass was identified through genome-wide association studies (GWAS). These studies scan the genomes of large groups of people to find statistical correlations between specific genetic variants and observable traits. The evidence for this particular association is currently considered moderate. This means that while a statistical link has been observed in research cohorts, it does not imply a direct cause-and-effect relationship. Genetic associations are often complex, influenced by a combination of multiple genes, environmental factors, and lifestyle choices. Because the evidence is based on population-level data, it is important to interpret these findings as a piece of a much larger puzzle rather than a definitive predictor of an individual's physical health or body composition.
Population Frequency and Distribution
The rs144493374 variant is characterized as rare across human populations. In genetic research, a variant is typically considered rare if it appears at a very low frequency in the general population. Because of this rarity, it is difficult to draw broad conclusions about how this variant might manifest across different ancestral groups without extensive, large-scale data. Most individuals will not carry this specific variant. When a variant is rare, the statistical power to detect its effects is often limited, which is why the evidence strength remains moderate. Researchers continue to monitor such variants in diverse cohorts to better understand if their association with traits like trunk fat mass remains consistent across different genetic backgrounds or if it is specific to certain populations.
Interpreting Your Genetic Information
If you have received information about your status for the rs144493374 variant, it is important to understand what this means in a practical sense. This information is intended for educational purposes and should not be used to make medical decisions or to diagnose health conditions. Genetic variants are only one of many factors that influence human traits; diet, physical activity, and overall health history play significant roles in body composition. You cannot change your genetic code, but you can focus on evidence-based lifestyle choices that support your well-being. If you have concerns about your health, body composition, or weight management, the best course of action is to consult with a qualified healthcare provider or a registered dietitian. They can provide personalized guidance based on your clinical history rather than relying on a single genetic marker.
How common is this variant?
The rs144493374 variant is classified as rare, meaning it is found at a very low frequency across most human populations.
Frequently asked questions
What is the PALLD gene?
The PALLD gene provides instructions for making a protein called palladin, which is important for the structure and movement of cells. It helps maintain the cytoskeleton, which acts as the cell's internal framework.
Does having this variant mean I will have more trunk fat?
No. Genetic associations are statistical correlations found in large groups and do not predict individual outcomes. Many factors, including lifestyle and environment, have a much larger impact on body composition.
Is rs144493374 a disease-causing mutation?
No, this variant is not classified as a disease-causing mutation. It is a genetic marker associated with a trait in research studies, which is different from a mutation that directly causes a medical condition.
Should I be worried about my result for this SNP?
There is no reason to be worried. This variant is a normal part of human genetic diversity, and its association with trunk fat mass is only one small factor among many that influence your health.
Sources & further reading
Educational information only, last refreshed 9/15/2026. Not medical advice — these associations describe population statistics, not individual predictions.
Curious what your genotype is for rs144493374?
Upload a raw DNA file from 23andMe, AncestryDNA, MyHeritage, or FamilyTreeDNA and see this variant — plus thousands more — interpreted in your full report.
Get my report — $29