DPYSL5 rs145095347: What Your Genotype Means
The genetic variant rs145095347 is located within the DPYSL5 gene. It has been identified in scientific literature as a significant locus associated with brain fluid dynamics and the function of the glymphatic system.
What each genotype means
Typical brain fluid dynamics
This genotype represents the most common sequence observed at this location in the DPYSL5 gene. Research suggests this version of the gene is associated with standard patterns of brain fluid dynamics and glymphatic system function. As this is the common form, it is generally considered the baseline for comparison in studies of brain structure.
This is the most frequent genotype found across global populations.
Variant brain fluid association
Carrying one copy of the T allele at this position has been identified as a locus associated with variations in brain fluid dynamics and glymphatic system function. Because this variant is rare, the specific functional consequences for an individual are not fully established and may be influenced by other genetic or environmental factors. Please note that this association is based on statistical population data and does not provide a clinical diagnosis.
This heterozygous genotype is rare and observed at low frequencies across most studied ancestral groups.
Rare variant brain association
This genotype involves two copies of the rare T allele, which has been linked to differences in brain fluid dynamics and glymphatic system function. Current research is limited regarding the specific physiological impact of this homozygous state, and it is important to interpret these findings as statistical associations rather than medical outcomes. Further clinical research is required to understand the full implications of this specific genetic profile.
This homozygous genotype is extremely rare in the general population.
Understanding the Variant
The identifier rs145095347 refers to a specific single nucleotide polymorphism (SNP) located within the DPYSL5 gene. In genomics, a SNP represents a variation at a single position in the DNA sequence among individuals. This particular variant is categorized as a trait-associated marker. Researchers study such variants to understand how subtle differences in our genetic code might influence physiological processes. Because this variant is located within a gene, it has the potential to influence how that gene is expressed or how the resulting protein functions within the body. Geneticists use these markers to map complex biological traits, providing a foundation for further investigation into how our DNA contributes to the maintenance of brain health and fluid regulation.
The Role of DPYSL5
The DPYSL5 gene, also known as CRMP5, encodes a cytosolic phosphoprotein that belongs to the collapsin response mediator protein family. This protein is primarily recognized for its role as a negative regulator of neurite and dendrite outgrowth, which are critical processes in the development and maintenance of the nervous system. By influencing the structural integrity and growth of neurons, DPYSL5 plays a vital part in neurodevelopmental pathways. Beyond its structural roles, recent research has begun to explore its involvement in broader neurological functions, including the regulation of fluid dynamics within the brain. Understanding the function of this gene is essential for interpreting how variants like rs145095347 might influence the complex environment of the central nervous system.
Research and Evidence
The association between rs145095347 and brain fluid dynamics is supported by moderate evidence within the scientific community. Genome-wide association studies (GWAS) have highlighted this locus as a significant factor in the function of the glymphatic system, which is the brain's waste clearance pathway. While these findings are compelling, it is important to note that the evidence is considered moderate, meaning that while a statistical link exists, the biological mechanisms are still being actively researched. Most genetic associations are complex, and the presence of a specific variant does not guarantee a particular physiological outcome. As with many findings in the GWAS Catalog, these results represent population-level observations rather than individual clinical predictions, and further studies are required to fully elucidate the clinical significance of this specific genetic marker.
Population Frequency
The rs145095347 variant is classified as rare across human populations. In genetic research, a variant is typically considered rare if its frequency is very low within the general population. Because of its rarity, large-scale genomic studies are often required to gather enough data to draw meaningful conclusions about its distribution across different ancestral groups. The limited frequency of this variant means that it is not commonly found in the general public, which can make it more challenging to study compared to more frequent genetic markers. Researchers continue to monitor such rare variants to determine if their effects are consistent across diverse populations or if they are specific to certain ancestral backgrounds.
Interpreting Your Information
If you have information regarding your status for the rs145095347 variant, it is important to view it through an educational lens. This information describes statistical associations observed in large research cohorts and does not constitute a medical diagnosis or a prediction of your personal health. Genetic variants are only one piece of a much larger puzzle that includes environmental factors, lifestyle, and other genetic influences. You cannot use this information to make medical decisions or to self-diagnose conditions related to brain health. If you have concerns about your neurological health or questions about how your genetics might influence your well-being, the most appropriate step is to consult with a qualified healthcare professional or a genetic counselor who can provide context based on your full clinical history.
How common is this variant?
The rs145095347 variant is documented as rare in global populations, with its specific frequency varying depending on ancestral background.
Frequently asked questions
What is the glymphatic system?
The glymphatic system is a functional waste clearance pathway in the brain that uses cerebrospinal fluid to remove metabolic waste products. It is most active during sleep and is essential for maintaining brain health.
Does having this variant mean I have a brain condition?
No. This variant is associated with statistical trends in research studies and is not a diagnostic tool for any medical condition. Genetic associations are complex and do not determine individual health outcomes.
Where can I find more information on DPYSL5?
You can search for the DPYSL5 gene on resources like the NCBI Gene database or the GWAS Catalog. These sites provide detailed information on gene function and known research associations.
Should I be worried about this variant?
There is no reason for concern based on a single genetic variant. Genetic markers are common, and most do not have a significant impact on daily health; always consult a doctor for health-related questions.
Sources & further reading
Educational information only, last refreshed 10/5/2026. Not medical advice — these associations describe population statistics, not individual predictions.
Curious what your genotype is for rs145095347?
Upload a raw DNA file from 23andMe, AncestryDNA, MyHeritage, or FamilyTreeDNA and see this variant — plus thousands more — interpreted in your full report.
Get my report — $29