CD55 rs1652333: What Your Genotype Means
The rs1652333 variant is a single-nucleotide polymorphism located in the CD55 gene. It has been associated with longitudinal changes in axial length, suggesting a potential role in the regulation of ocular growth.
What each genotype means
Typical ocular growth
This genotype is associated with standard longitudinal changes in axial length during childhood. While linked to ocular growth regulation in some studies, the evidence remains limited.
This genotype is common in East Asian populations.
Varied ocular growth
Carriers of this genotype may show slight differences in the rate of axial length change over time. This association has been observed in longitudinal studies of children, though the clinical significance is not fully established.
This genotype is frequently observed in East Asian populations.
Associated with ocular growth
This genotype is statistically associated with 3-year longitudinal changes in axial length. These findings suggest a role in ocular growth regulation, but the association is complex and requires further research.
This genotype is common in East Asian populations.
What is the rs1652333 Variant?
The rs1652333 variant is a single-nucleotide polymorphism (SNP) found within the CD55 gene. SNPs are the most common type of genetic variation among people, representing a difference in a single DNA building block, or nucleotide. The CD55 gene is involved in the regulation of the complement system, which is part of the immune response, but research has also identified its potential relevance to ocular traits. When scientists identify a SNP like rs1652333, they investigate whether the presence of different alleles at this location correlates with specific physical characteristics. In this instance, the research focuses on the eye, specifically how the eye grows and changes over time. It is important to remember that genetic variants are often located in non-coding regions of the genome, meaning they may influence how genes are turned on or off rather than changing the structure of a protein directly. This makes the study of such variants a complex area of modern genomics.
Research and Ocular Growth
Research has linked the rs1652333 variant to longitudinal changes in axial length, which is the measurement of the eye from front to back. Studies, such as those published in the British Journal of Ophthalmology, have observed that this variant is associated with how the eye changes over a three-year period. The evidence for this association is currently described as limited, indicating that while the finding is statistically significant in the studied cohorts, it is not a universal rule for all individuals. Furthermore, this SNP has been identified in studies exploring regulatory variants in refractive error, suggesting it may play a role in the biological pathways that control eye globe growth. Because these studies often focus on specific populations, such as East Asian schoolchildren, the findings may not be generalizable to all ancestries. The association is a statistical observation, highlighting a potential area for further biological investigation rather than a definitive clinical finding.
Understanding Your Genetic Information
It is important for readers to understand the scope and limitations of genetic association data. Information regarding the rs1652333 variant is intended for educational purposes and to provide insight into ongoing scientific research. It is not a diagnostic tool, and it cannot predict an individual's future eye health or refractive status. Because eye growth is a complex process influenced by many genetic and environmental factors, a single SNP like rs1652333 provides only a very small amount of information. Individuals should not use this data to make medical decisions or to draw conclusions about their own health. If you have questions about your vision or the health of your eyes, the most reliable source of information is a qualified eye care professional. They can provide personalized assessments and evidence-based care. Genetic research is a powerful tool for understanding human biology, but it is not a substitute for professional medical advice and clinical examination.
How common is this variant?
The rs1652333 variant is common in East Asian populations, where it has been frequently studied in the context of ocular biometry and refractive error.
Frequently asked questions
Is rs1652333 a marker for eye disease?
No, rs1652333 is not a clinical marker for eye disease. It is a genetic variant associated with statistical changes in axial length in research studies, which is different from a diagnostic test for a specific condition.
Can I use this SNP to know if I will need glasses?
No, you cannot use this SNP to determine if you will need glasses. Refractive error is a complex trait influenced by many factors, and this variant does not provide a reliable prediction for an individual's vision needs.
Where can I find more information about CD55 and the eye?
You can search for 'CD55' and 'refractive error' on PubMed or the GWAS Catalog. These resources provide peer-reviewed articles that explain the current scientific understanding of how this gene relates to ocular traits.
What should I do if I am worried about my eye growth?
If you are concerned about your eye growth or vision, you should schedule an appointment with an eye care professional. They can perform a comprehensive exam and provide advice based on your individual health history.
Sources & further reading
Educational information only, last refreshed 11/7/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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