ADIPOQ rs1800057: What Your Genotype Means
The rs1800057 variant is a single nucleotide polymorphism located in the promoter region of the ADIPOQ gene. It is primarily studied for its potential association with circulating levels of adiponectin, a protein hormone involved in regulating glucose levels and fatty acid breakdown.
What each genotype means
Typical adiponectin expression
This is the most common genotype for this variant in many populations. Research suggests this genotype is associated with baseline levels of circulating adiponectin, a hormone that helps regulate glucose and lipid metabolism.
This is the major homozygous genotype, found in the majority of individuals of European ancestry.
Intermediate adiponectin profile
Carrying one copy of the A allele may be associated with slight variations in circulating adiponectin levels compared to the GG genotype. Because the evidence linking this specific variant to clinical outcomes like insulin resistance is limited and often inconsistent across studies, this result should be viewed as a minor genetic marker rather than a diagnostic indicator.
Carried by roughly 1 in 5 to 1 in 4 people of European ancestry.
Potential altered adiponectin levels
This genotype represents the homozygous state for the minor allele. Some studies have associated this variant with differences in adiponectin levels, which may influence metabolic traits; however, the evidence remains limited and results vary significantly between different ethnic groups. It is not a definitive predictor of health outcomes, and any concerns regarding metabolic health should be discussed with a healthcare provider.
This is the least common genotype, occurring in approximately 1% to 2% of individuals of European ancestry.
Understanding the rs1800057 Variant
The rs1800057 variant is a specific change in the DNA sequence located within the promoter region of the ADIPOQ gene. In genetics, a promoter is a region of DNA that initiates the transcription of a particular gene. By sitting in this regulatory area, the variant is hypothesized to influence how much of the ADIPOQ gene product is created. This specific SNP is often referred to in literature as the -11391G>A variant. Because it is located in a non-coding regulatory region rather than the protein-coding sequence itself, it does not change the structure of the adiponectin protein, but rather may alter the efficiency or timing of its production. Researchers study such variants to understand the genetic architecture behind individual differences in hormone levels.
The Role of the ADIPOQ Gene
The ADIPOQ gene provides instructions for making a protein called adiponectin. This hormone is secreted by adipose tissue (body fat) and plays a critical role in metabolic processes, including the regulation of glucose levels and the breakdown of fatty acids. Adiponectin is known for its insulin-sensitizing and anti-inflammatory properties. Because it helps the body manage energy and metabolism, researchers have long investigated how variations in the ADIPOQ gene might contribute to metabolic conditions. When adiponectin levels are low, it is sometimes observed in association with insulin resistance and other metabolic markers. However, the relationship between specific genetic variants, protein levels, and clinical health outcomes is complex and influenced by many environmental and lifestyle factors.
Research Associations and Evidence Strength
Scientific research into rs1800057 has primarily focused on its association with circulating adiponectin levels. While some studies have explored links between ADIPOQ variants and metabolic traits like type 2 diabetes or obesity, the evidence for rs1800057 specifically is considered limited. Genetic associations can be inconsistent across different populations, and it is common for a variant to show a statistical signal in one study but not in another. Furthermore, many of these associations are modest, meaning the variant explains only a small fraction of the total variation in adiponectin levels. It is important to note that these findings are based on population-level statistics and do not predict an individual's health status. The field continues to evolve as larger, more diverse genomic studies are conducted to clarify these relationships.
What You Can and Cannot Do With This Information
Genetic information regarding variants like rs1800057 is intended for educational and research purposes. It is not a diagnostic tool and cannot predict whether an individual will develop a specific health condition. Because the evidence linking this variant to clinical outcomes is limited and often inconsistent, it should not be used to make medical decisions or lifestyle changes. If you have concerns about your metabolic health, such as blood sugar levels or weight management, the most effective approach is to consult with a healthcare professional. They can provide personalized guidance based on your clinical history, blood work, and overall health profile. Never use genetic data to self-diagnose or alter any prescribed medical treatments without direct supervision from your doctor.
How common is this variant?
The minor allele frequency for rs1800057 is approximately 0.10 to 0.15 in European populations, meaning the variant is relatively common but not the majority allele.
Frequently asked questions
Is rs1800057 a cause of diabetes?
No, rs1800057 is not considered a direct cause of diabetes. While some research explores associations between ADIPOQ variants and metabolic traits, genetics is only one of many factors that influence health.
Can I use this SNP to predict my adiponectin levels?
No, you cannot use this SNP to accurately predict your personal adiponectin levels. Many factors, including diet, physical activity, and overall body composition, have a much larger impact on hormone levels than this specific genetic variant.
Should I get tested for this variant?
There is no clinical utility in testing for this variant for the general public. It does not provide actionable medical information that would change your standard of care or health management.
Where can I find more information on ADIPOQ?
You can find reliable information on the ADIPOQ gene and its functions through resources like MedlinePlus Genetics or the NCBI Gene database. These sites provide comprehensive, peer-reviewed summaries of human genes.
Sources & further reading
Educational information only, last refreshed 10/26/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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Common regulatory polymorphism in the ADIPOQ gene associated with circulating adiponectin levels.
This SNP is associated with circulating adiponectin levels and metabolic syndrome risk.
This SNP is studied for its role in adiponectin levels and metabolic response to diet.
This SNP in the adiponectin gene is associated with insulin sensitivity and metabolic syndrome risk.
A candidate SNP in the adiponectin gene investigated for its potential association with human longevity and aging phenotypes.
A variant in the ADIPOQ gene linked to inflammatory regulation and insulin sensitivity in the context of dietary intake.