SLC15A5 rs192667895: Understanding This Rare Genetic Variant
The rs192667895 variant is a rare genetic change located within the SLC15A5 gene. Current clinical databases classify this specific missense variant as likely benign, meaning it is not currently associated with any known medical conditions.
What each genotype means
Typical genetic profile
This genotype represents the most common version of the SLC15A5 gene found in the general population. Current clinical databases classify this variant as likely benign, meaning it is not expected to cause disease or impact normal biological function.
This is the most common genotype observed across all major global populations.
Carrier of rare variant
You carry one copy of this rare missense variant in the SLC15A5 gene. Clinical databases currently annotate this variant as likely benign, and there is no established evidence linking this specific change to any known medical condition or clinical disorder.
This genotype is rare and observed at a very low frequency in global population databases.
Carrier of rare variant
You carry two copies of this rare missense variant in the SLC15A5 gene. While this variant is classified as likely benign in clinical databases, it remains a rare genetic finding with no established association to specific health outcomes or disease states in current scientific literature.
This genotype is extremely rare and is found in a very small fraction of individuals across studied ancestries.
What is rs192667895?
The identifier rs192667895 refers to a specific single nucleotide polymorphism (SNP) found in the human genome. In genetics, a SNP represents a variation at a single position in a DNA sequence. This particular variant is located within the SLC15A5 gene. When scientists identify a SNP, they assign it an 'rs' number to track it across different studies and databases. Because the human genome is vast, these identifiers are essential for researchers to communicate precisely about which location in the DNA they are investigating. For rs192667895, the variant is classified as a missense mutation, which means the change in the DNA sequence results in a different amino acid being incorporated into the protein structure. However, not all missense changes affect how a protein functions, and many are considered harmless variations that naturally occur within the human population.
The Role of the SLC15A5 Gene
The SLC15A5 gene encodes a protein that belongs to the solute carrier family. Proteins in this family are primarily localized to cell membranes, where they act as gatekeepers, facilitating the movement of various substances into and out of cells. Specifically, SLC15A5 is predicted to be involved in transmembrane transport, including the movement of peptides and other molecules across cellular boundaries. Research indicates that this gene is expressed in several tissues, including the brain and the male reproductive system, with protein detection also noted in the gastrointestinal tract. By helping to transport essential nutrients or signaling molecules, SLC15A5 contributes to the complex biological processes required for cellular health. Understanding the function of this gene helps researchers determine whether variations within it might disrupt these transport mechanisms or if they are simply part of the normal range of human genetic diversity.
Research and Clinical Evidence
In the context of clinical genetics, rs192667895 is currently categorized as likely benign. This classification is based on the evaluation of available data in clinical databases, which aggregate information from various studies to determine the potential impact of genetic variants on human health. Currently, there is no strong evidence linking this specific variant to any disease or clinical phenotype. It is important to note that the field of genomics is constantly evolving; as more data is collected and analyzed, our understanding of specific variants can change. For now, the scientific consensus suggests that this variant does not pose a significant risk to health. Researchers continue to monitor such variants to ensure that as new information emerges, clinical interpretations remain accurate and up-to-date for the benefit of patients and the medical community.
Population Frequency and Interpretation
The rs192667895 variant is considered rare across global populations. Population databases, such as the Genome Aggregation Database (gnomAD), provide researchers with the ability to see how often a specific variant appears in large, diverse groups of people. By comparing the frequency of a variant in the general population to its presence in individuals with specific conditions, scientists can better estimate its potential impact. Because this variant is rare, it is not frequently observed in standard genetic testing panels. When a variant is rare and lacks strong evidence for pathogenicity, it is often classified as a variant of uncertain significance or likely benign. This highlights the importance of large-scale genomic studies, which allow scientists to distinguish between rare, harmless variations and those that might contribute to rare genetic disorders.
What This Information Means for You
If you have encountered this variant in a genetic report, it is helpful to understand that it is currently classified as likely benign. This means that, based on current scientific knowledge, it is not expected to cause health issues. Genetic information can be complex, and it is normal to have questions about what specific findings mean for your health. It is important to remember that this information is for educational purposes and should not be used to make medical decisions or diagnoses. If you are concerned about your genetic results or have questions about how they relate to your personal health history, the best course of action is to consult with a qualified healthcare provider or a genetic counselor. These professionals can help you interpret your results in the context of your overall health and provide guidance tailored to your specific needs.
How common is this variant?
The rs192667895 variant is rare, with low allele frequencies observed across diverse ancestral groups in large-scale genomic databases.
Frequently asked questions
Is rs192667895 associated with any diseases?
No, current clinical databases classify rs192667895 as likely benign. There is no established evidence linking this variant to any specific medical condition.
What does 'likely benign' mean in a genetic report?
A 'likely benign' classification means that scientists have evaluated the variant and determined it is very unlikely to cause disease. It is considered a normal variation in the human genome.
Should I be worried if I have this variant?
Because this variant is classified as likely benign, it is not considered a cause for concern. If you have specific health questions, you should discuss them with your doctor.
Where can I find more information about SLC15A5?
You can find detailed information about the SLC15A5 gene on resources like GeneCards or the NCBI Gene database. These sites provide comprehensive summaries of gene function and expression.
Sources & further reading
Educational information only, last refreshed 9/16/2026. Not medical advice — these associations describe population statistics, not individual predictions.
Curious what your genotype is for rs192667895?
Upload a raw DNA file from 23andMe, AncestryDNA, MyHeritage, or FamilyTreeDNA and see this variant — plus thousands more — interpreted in your full report.
Get my report — $29