TENM4 rs1941379: Understanding Stress and Genetic Associations
The rs1941379 variant is a single nucleotide polymorphism located within the TENM4 gene. Research has statistically associated this variant with changes in stress-induced gene expression in the hippocampus and potential susceptibility to depressive behaviors.
What each genotype means
Typical stress response
You carry two copies of the major A allele for rs1941379 in the TENM4 gene. Research examining hippocampal gene expression under stress models indicates that this baseline genotype is not associated with elevated vulnerability to stress-induced behavioral changes. However, environmental factors and broader lifestyle patterns play substantial roles in overall resilience.
Carried by approximately 56% of individuals of European ancestry and is the predominant genotype worldwide.
Moderately altered stress sensitivity
You carry one copy of the G risk allele and one copy of the A allele for rs1941379. Observational and animal cross-species studies correlate this variant with altered TENM4 expression in the hippocampus following chronic stress, which may moderately influence behavioral vulnerability to stress. This finding reflects population-level statistical risk rather than a medical diagnosis.
Carried by approximately 38% of people of European ancestry.
Elevated stress sensitivity profile
You carry two copies of the G risk allele for rs1941379 within the TENM4 locus. Translational studies link this genotype to lower TENM4 expression and higher sensitivity to chronic stress-related depressive behaviors in comparative models. Evidence remains observational and polygenic, meaning individual resilience is heavily shaped by psychological, social, and environmental supports.
Found in approximately 6% of people of European ancestry and is less common in most non-European populations.
What is the rs1941379 Variant?
The rs1941379 variant is a single nucleotide polymorphism (SNP), which is a variation at a single position in the DNA sequence. It is located within the TENM4 gene, which resides on chromosome 11. In genomics, SNPs are the most common type of genetic variation among people. Each SNP represents a difference in a single DNA building block, called a nucleotide. While many SNPs have no effect on health, researchers study them to understand how specific genetic regions might influence biological processes or susceptibility to certain conditions. The rs1941379 variant is specifically noted in scientific literature for its presence within the genomic region of the TENM4 gene, which has been the subject of various association studies regarding neurological and behavioral traits.
The Role of the TENM4 Gene
The TENM4 gene encodes the teneurin transmembrane protein 4. This protein plays a critical role in the development of the nervous system, particularly in establishing proper neuronal connectivity and regulating axon guidance. It is also involved in the process of myelination, which is the formation of the protective sheath around nerve fibers that allows for efficient electrical signaling. Because of its function in the brain, researchers have investigated the TENM4 gene in the context of various neurological and psychiatric conditions. Beyond its role in the brain, the gene is expressed in other tissues, including the ovary and thyroid. Understanding how variations in this gene affect protein function is an active area of research, as mutations in TENM4 have been linked to specific hereditary conditions like essential tremor in some populations.
Research and Evidence Strength
The evidence linking rs1941379 to stress-related outcomes is considered moderate and is primarily based on statistical associations observed in research studies. Published research has identified this SNP as having significant associations with stress-induced changes in hippocampal gene expression. In some studies, this variant and others within the same gene region have been analyzed for their potential link to depressive behaviors. It is important to note that these findings are based on population-level statistical correlations rather than direct causation. Furthermore, genetic associations can be complex and influenced by environmental factors, gene-gene interactions, and ancestry. While the data suggests that the TENM4 gene is a potential target for understanding the molecular basis of stress responses, the clinical significance of this specific SNP remains a subject of ongoing scientific investigation.
Population Frequency
The rs1941379 variant is observed across various populations, with a minor allele frequency of approximately 0.25 in European ancestry populations. This means that a significant portion of the population carries at least one copy of the variant allele.
Interpreting Genetic Information
Genetic information regarding variants like rs1941379 provides insight into biological predispositions but does not serve as a medical diagnosis. A reader cannot use this information to predict personal health outcomes or to make decisions about medical treatment. Statistical associations found in research studies describe trends across large groups of people and do not necessarily apply to an individual's specific health profile. If you are concerned about stress, mood, or any other health condition, it is essential to consult with a qualified healthcare professional. They can provide context based on your personal medical history, lifestyle, and clinical symptoms. Never use genetic data to self-diagnose or alter any prescribed medication regimens without direct guidance from your clinician or pharmacist.
How common is this variant?
The rs1941379 variant has a minor allele frequency of approximately 0.25 in European ancestry populations, making it a relatively common genetic variation.
Frequently asked questions
Does having the rs1941379 variant mean I will develop depression?
No. Genetic variants like rs1941379 are associated with statistical trends in populations, not individual outcomes. Many factors, including environment and lifestyle, contribute to mental health.
Is rs1941379 a diagnostic test for stress?
No. There is no clinical diagnostic test for stress based on this SNP. Genetic associations are used for research purposes to understand biological pathways.
Can I change my gene expression related to TENM4?
Gene expression is a complex biological process influenced by many factors. While research explores how genes interact with the environment, there is no established way to target this specific variant for clinical intervention.
Where can I find more information about my specific genetic results?
If you have received results from a genetic testing service, consult the documentation provided by that service. For health-related concerns, always speak with a doctor or a genetic counselor.
Sources & further reading
Educational information only, last refreshed 10/19/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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An intronic variant in the TENM4 gene identified as a significant marker in cross-species studies linking restraint stress to depressive phenotypes.
This variant is in linkage disequilibrium with haplotypes in the TENM4 gene that are associated with hippocampal gene expression changes and susceptibility to stress-induced depressive behaviors.