SLC6A2 rs2070762: What Your Genotype Means
The rs2070762 variant is a single nucleotide polymorphism located within the SLC6A2 gene, which encodes the norepinephrine transporter. Research has investigated whether this genetic variation influences how individuals with ADHD respond to methylphenidate treatment.
What each genotype means
Reduced methylphenidate response
Research suggests that individuals with this genotype may show a decreased response to methylphenidate treatment compared to those carrying the T allele. This effect may be more pronounced in children with a history of prenatal tobacco exposure. Please discuss your medication response and any dosing concerns with your clinician or pharmacist.
This genotype is common, with a reported minor allele frequency for the C allele of approximately 0.42 in some studied populations.
Typical methylphenidate response
Individuals with this genotype carry one copy of the T allele, which has been associated with a more favorable response to methylphenidate compared to the CC genotype in some studies. This association is based on limited evidence and should not be used to predict individual clinical outcomes. Please discuss your treatment plan and medication efficacy with your healthcare provider.
This heterozygous genotype is frequently observed in diverse populations, reflecting the common distribution of both C and T alleles.
Typical methylphenidate response
Individuals with this genotype carry two copies of the T allele, which has been associated with a more favorable response to methylphenidate compared to the CC genotype in some studies. As this evidence is limited and based on observational research, it does not guarantee a specific clinical result. Please discuss your medication response and any treatment adjustments with your clinician or pharmacist.
This genotype is common, occurring at a frequency consistent with the prevalence of the T allele in the general population.
Understanding the Variant and Gene
The rs2070762 variant is a specific change in the DNA sequence of the SLC6A2 gene. This gene provides instructions for creating the norepinephrine transporter (NET), a protein responsible for clearing norepinephrine from the synaptic cleft between neurons. By regulating the levels of this neurotransmitter, the NET protein plays a critical role in brain signaling pathways related to attention and arousal. Because methylphenidate is a medication that modulates catecholamine levels—including norepinephrine—researchers have long hypothesized that variations in the genes controlling these transporters might influence how effectively the drug works for different people. The rs2070762 SNP is one of several markers within this gene that scientists have examined to see if it acts as a predictor for treatment outcomes in patients diagnosed with attention-deficit/hyperactivity disorder (ADHD).
Research and Evidence Strength
The evidence linking rs2070762 to methylphenidate response is currently considered limited. While some studies have explored the relationship between SLC6A2 variants and ADHD medication efficacy, results have been inconsistent across different populations and clinical settings. For instance, while certain genotypes have been associated with poorer responses in specific patient subgroups—particularly those with lower baseline ADHD severity—other studies have failed to replicate these findings or have found no statistically significant association after correcting for multiple testing. The complexity of ADHD, combined with the fact that medication response is likely influenced by many genes rather than a single variant, makes it difficult to draw definitive clinical conclusions. Consequently, this variant is not currently used as a standard diagnostic or predictive tool in clinical practice, and any observed associations should be viewed as preliminary findings requiring further validation.
Clinical Implications and Next Steps
It is important to understand that genetic information regarding rs2070762 cannot be used to diagnose ADHD or to determine the best treatment plan on its own. Because the evidence is limited and mixed, this variant does not provide a reliable basis for making medical decisions. If you are curious about how your genetics might relate to your medication, it is essential to discuss this with your healthcare provider or a clinical pharmacist. They can help you interpret information in the context of your overall health, medical history, and current treatment goals. Never make changes to your medication regimen, such as stopping or adjusting your dose, based on genetic test results without direct supervision from your doctor. Personalized medicine is an evolving field, and clinical decisions should always be based on comprehensive clinical assessments rather than individual genetic markers.
How common is this variant?
The frequency of the rs2070762 variant is variable across different global populations, and specific allele frequencies depend on ancestral background.
Frequently asked questions
Can I use this genetic test to see if methylphenidate will work for me?
No. The evidence linking rs2070762 to methylphenidate response is limited and inconsistent. It is not a reliable tool for predicting how an individual will respond to ADHD medication.
What does the SLC6A2 gene do?
The SLC6A2 gene encodes the norepinephrine transporter, a protein that helps regulate the levels of norepinephrine in the brain. This neurotransmitter is involved in attention and focus.
Should I change my ADHD medication based on my genotype?
Absolutely not. You should never change your medication or dosage based on genetic test results without consulting your doctor. Medication adjustments must be managed by a healthcare professional.
Is this variant a diagnostic test for ADHD?
No. ADHD is a complex condition diagnosed through clinical evaluation by a healthcare professional. Genetic variants like rs2070762 are not used for diagnosis.
Sources & further reading
Educational information only, last refreshed 10/9/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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This variant, also known as -3081A>T, is a significant contributor to individual differences in response to methylphenidate administration.
The G/G genotype of this variant is associated with an improved response to methylphenidate compared to A allele carriers.