ABCB1 rs2235067: what the research says
This variant is part of a linkage block in the ABCB1 gene associated with antidepressant treatment response.
What each genotype means
Typical ABCB1 genotype
This genotype represents the most common form of the ABCB1 gene at this location. While some research has explored whether this variant influences how antidepressants are transported across the blood-brain barrier, results remain inconsistent and inconclusive. You should discuss any concerns regarding your medication response or dosing directly with your clinician or pharmacist.
This is the most common genotype observed across most global populations.
Heterozygous ABCB1 variant
You carry one copy of the variant allele at this position. Research into whether this specific variant affects antidepressant efficacy has produced mixed findings, with some studies suggesting a potential link to drug transport and others finding no significant clinical impact. Please consult your healthcare provider to discuss your treatment plan and any necessary medication adjustments.
This genotype is found at moderate frequencies in many populations, though exact prevalence varies by ancestry.
Homozygous ABCB1 variant
You carry two copies of the variant allele at this position. Because this variant is part of a linkage block in the ABCB1 gene, it is often studied alongside other markers to understand potential variations in drug response. Current scientific evidence is conflicting regarding whether this genotype significantly alters clinical outcomes, so it should not be used to guide medical decisions without professional clinical oversight.
This genotype is less common than the CC or CT genotypes in most studied populations.
Common
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Influences the expression of P-glycoprotein, impacting the transport and clearance of numerous medications including digoxin and certain statins.
A tri-allelic variant (2677T>G/A) in the ABCB1 gene that influences drug transport and is associated with susceptibility to inflammatory bowel disease.
This variant is studied for its influence on the pharmacokinetics of immunosuppressive drugs like cyclosporine and tacrolimus in transplant patients.
This variant in the ABCB1 gene, which encodes the P-glycoprotein transporter, is a well-established marker for drug transport across the blood-brain barrier and drug efflux.
This SNP is located in the ABCB1 gene and is associated with the regulation of drug efflux pumps that influence intracerebral drug concentrations.
Synonymous variant (c.3435C>T) in ABCB1 linked to altered P-glycoprotein expression and multi-drug transporter pharmacokinetics.