rs2286823: Understanding Genetic Associations with Clopidogrel
The rs2286823 variant is a single nucleotide polymorphism located in an intergenic region of the human genome. It has been identified in research studies as a potential marker associated with how individuals respond to clopidogrel, a common antiplatelet medication.
What each genotype means
Typical platelet aggregation profile
This genotype represents the common form of this genetic variant. Research indicates that this variant is associated with variations in platelet aggregation response to clopidogrel, though the clinical significance of this specific genotype remains a subject of ongoing study. Please discuss any concerns regarding medication response or cardiovascular health with your clinician or pharmacist.
This genotype is common in many populations, though its frequency varies significantly by ancestry.
Varied platelet aggregation profile
This genotype represents a heterozygous state for this variant. Studies have suggested that this variant may influence how platelets aggregate in response to clopidogrel, with some evidence of frequency differences in Latin American populations. Because individual responses to medication are complex, please consult your healthcare provider or pharmacist to discuss how this might relate to your specific health profile.
This genotype is found at varying frequencies across global populations, with notable prevalence in Latin American cohorts.
Varied platelet aggregation profile
This genotype represents the alternative homozygous state for this variant. Research has linked this variant to differences in platelet aggregation response to clopidogrel, particularly in specific ancestral groups. As this is a complex trait influenced by many factors, please consult with your clinician or pharmacist regarding any implications for your medical care.
This genotype is observed at varying frequencies globally, with specific prevalence patterns noted in Latin American populations.
What is rs2286823?
A single nucleotide polymorphism, or SNP, is a variation at a single position in a DNA sequence among individuals. The variant rs2286823 is classified as an intergenic SNP, meaning it is located in the non-coding DNA between genes rather than within a gene that provides instructions for making a protein. Because it sits in these regulatory regions, researchers investigate whether it might influence the expression of nearby genes or play a role in complex biological pathways. In the context of pharmacogenomics, scientists look for such variants to see if they correlate with how different people process or respond to specific pharmaceutical treatments. While rs2286823 does not reside in a protein-coding sequence, its presence is tracked in genomic databases to help map the landscape of human genetic diversity and its potential influence on health-related traits.
Research and Clopidogrel Response
Clopidogrel is a widely used antiplatelet medication prescribed to prevent blood clots in patients with cardiovascular disease. Research into the genetic basis of clopidogrel response has historically focused on the CYP2C19 gene, which is critical for converting the drug into its active form. However, studies have also explored other genomic regions to understand why some patients exhibit high on-treatment platelet reactivity (HTPR). The variant rs2286823 has been noted in scientific literature as a marker of interest in studies examining these response differences. It is important to note that the evidence linking this specific variant to clinical outcomes is considered moderate. Genetic associations are often complex, and many factors—including other genetic variants, environmental influences, and medication adherence—contribute to how a patient responds to therapy. Current research continues to evaluate how such markers might eventually contribute to more personalized approaches in cardiovascular medicine.
Understanding Genetic Associations
When scientists report that a variant like rs2286823 is associated with a trait, they are describing a statistical correlation observed in a specific study population. This does not necessarily mean the variant causes the trait directly. Instead, it may be in linkage disequilibrium with another functional variant, meaning they are inherited together. Furthermore, genetic associations can be highly ancestry-specific. A variant that shows a strong signal in one population may not show the same effect in another due to differences in genetic background and environmental factors. Because of this, findings must be replicated across diverse groups to confirm their clinical relevance. Readers should view these associations as pieces of a larger puzzle rather than definitive predictors of individual health outcomes. Genomic research is an evolving field, and the interpretation of these markers often changes as more data becomes available from larger and more diverse cohorts.
What You Can Do With This Information
Information about genetic variants like rs2286823 is intended for educational purposes and should not be used to make personal medical decisions. If you are taking clopidogrel or any other medication, it is essential to discuss your treatment plan, potential side effects, and any concerns about drug efficacy with your healthcare provider or pharmacist. They are the only ones qualified to interpret your medical history in the context of your overall health. Never change your medication dosage or stop taking a prescribed drug based on information found in genetic databases or online reports. If you are interested in how your genetics might influence your response to medications, ask your doctor about pharmacogenetic testing. Such tests are performed in clinical settings and are interpreted by professionals who can provide guidance based on established clinical guidelines and your specific health needs.
How common is this variant?
The frequency of the rs2286823 alleles varies significantly across different global populations, reflecting the diverse genetic architecture of human ancestries.
Frequently asked questions
Is rs2286823 a diagnostic test for clopidogrel response?
No, rs2286823 is not a diagnostic test. It is a genetic marker that has been studied for statistical associations with drug response, but it is not used in clinical practice to determine medication efficacy.
Should I change my medication if I have this variant?
Absolutely not. You should never alter your medication regimen based on genetic information without consulting your doctor. Only a healthcare professional can determine if your treatment plan is appropriate for you.
Where can I find more information about my own genetic data?
If you have undergone genetic testing, you should consult the report provided by your testing service or discuss your results with a genetic counselor. They can help you understand the limitations and context of your specific data.
Why do studies show different results for the same variant?
Genetic studies often differ due to variations in study design, sample size, and the ancestral background of the participants. These differences can lead to varying statistical results, which is why replication in diverse populations is necessary.
Sources & further reading
Educational information only, last refreshed 10/3/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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