NARS2 rs2373115: Understanding This Alzheimer's Risk Variant
The rs2373115 variant is a genetic change located within the NARS2 gene. Research has identified this variant as having a statistical association with the risk of developing Alzheimer's disease in certain European cohorts.
What each genotype means
Typical risk profile
This genotype is considered the common baseline for this variant. Research regarding the association of this variant with Alzheimer's disease risk is currently mixed and inconclusive, with some reports suggesting only a very small or negligible effect on risk. This finding should not be used to predict personal health outcomes.
This is a common genotype found in diverse populations, with the G allele appearing at a frequency of approximately 70% in many cohorts.
Potential risk variation
Carriers of this genotype have one copy of the T allele, which has been investigated for potential links to Alzheimer's disease risk. Current scientific evidence is conflicting and limited, meaning it is unclear if this genotype meaningfully influences your personal risk profile. Please consult with a healthcare professional for comprehensive risk assessment rather than relying on individual genetic markers.
This heterozygous genotype is frequently observed in European and diverse global populations.
Potential risk variation
This genotype contains two copies of the T allele, which has been the subject of exploratory research regarding Alzheimer's disease susceptibility. Because reports on this variant are inconsistent and often describe only small or dubious associations, this result does not provide a clear clinical picture of your health risk. Always discuss concerns about cognitive health with a qualified clinician.
This genotype is less common than the G/G or G/T combinations but is present across various ancestral groups.
What is rs2373115?
The rs2373115 variant is a single nucleotide polymorphism (SNP) located within the NARS2 gene. In genetics, a SNP represents a variation at a single position in the DNA sequence among individuals. This specific variant is cataloged in public databases as a trait-associated marker. It sits within the genomic region of the NARS2 gene, which provides instructions for building a specific protein. Scientists study such variants to understand how subtle differences in our genetic code might influence complex health outcomes, such as neurodegenerative conditions. Because this variant is located in a regulatory or coding region of the gene, researchers investigate whether it alters how the NARS2 protein is produced or functions within the cell. It is important to note that the presence of a variant does not guarantee a health outcome; rather, it is a statistical signal identified through large-scale genome-wide association studies (GWAS) that compare the DNA of individuals with and without a specific condition.
The Role of the NARS2 Gene
The NARS2 gene encodes the asparaginyl-tRNA synthetase 2 enzyme, which is primarily located in the mitochondria. Mitochondria are the powerhouses of the cell, responsible for generating the energy required for various biological processes. The NARS2 enzyme plays a critical role in protein synthesis within these organelles by attaching the amino acid asparagine to its corresponding transfer RNA (tRNA). This process is essential for the proper assembly of proteins that are vital for mitochondrial function. Mutations in NARS2 have been linked to rare, severe conditions such as Leigh syndrome, which involves mitochondrial dysfunction. In the context of more common, late-onset conditions like Alzheimer's disease, researchers are exploring whether subtle variations in NARS2 expression or function might contribute to the gradual decline of cellular health in the brain. By maintaining mitochondrial integrity, NARS2 supports the high energy demands of neurons, making it a subject of interest in studies regarding neuroprotection and aging.
Research and Evidence Strength
The association between rs2373115 and Alzheimer's disease is currently classified as having moderate evidence strength. This classification comes from the GWAS Catalog, which aggregates findings from numerous large-scale genetic studies. These studies identify statistical correlations between specific genetic markers and disease risk across large populations. While the association has been observed in diverse European cohorts, it is crucial to understand that statistical association does not imply direct causation. Many factors, including other genetic variants, environmental influences, and lifestyle choices, contribute to the development of Alzheimer's disease. The evidence for rs2373115 is considered moderate because, while the signal is detectable in specific datasets, the biological mechanism linking this specific SNP to the disease process is still being actively researched. As with many complex traits, the genetic architecture of Alzheimer's is polygenic, meaning it involves the cumulative effect of many different variants, each contributing a small amount to the overall risk profile.
Population Frequency
The rs2373115 variant is found in European and other diverse cohorts. Its frequency can vary significantly depending on the ancestral background of the population being studied, which is a common observation for many genetic variants identified in GWAS.
What This Information Means for You
Understanding your genetic profile regarding variants like rs2373115 can be an educational experience, but it is not a diagnostic tool. Because the association with Alzheimer's disease is based on statistical trends across large groups, it cannot predict an individual's health outcome. You cannot use this information to diagnose yourself or to determine your personal risk with certainty. If you are concerned about your cognitive health or family history of Alzheimer's disease, the most effective step is to consult with a healthcare professional or a genetic counselor. They can provide context based on your full medical history, lifestyle, and other clinical factors. Avoid making medical decisions based solely on genetic data found in public databases. Always prioritize guidance from qualified clinicians who can interpret genetic information within the context of your overall health and well-being.
How common is this variant?
The rs2373115 variant is found in European and diverse cohorts, with allele frequencies varying across different ancestral populations.
Frequently asked questions
Does having the rs2373115 variant mean I will get Alzheimer's?
No. This variant is only associated with a statistical change in risk across large populations and is not a diagnostic marker for Alzheimer's disease.
What is the function of the NARS2 gene?
NARS2 encodes an enzyme that helps mitochondria produce proteins. It is essential for maintaining cellular energy production and overall mitochondrial health.
Where can I find more information on Alzheimer's genetics?
You can visit resources like MedlinePlus Genetics or the Alzheimer's Disease Variant Portal for curated, evidence-based information on the genetics of the disease.
Should I get tested for this variant?
Genetic testing for complex, late-onset conditions is generally not recommended for the general public. Consult a doctor or genetic counselor to discuss whether testing is appropriate for your specific situation.
Sources & further reading
Educational information only, last refreshed 9/24/2026. Not medical advice — these associations describe population statistics, not individual predictions.
Curious what your genotype is for rs2373115?
Upload a raw DNA file from 23andMe, AncestryDNA, MyHeritage, or FamilyTreeDNA and see this variant — plus thousands more — interpreted in your full report.
Get my report — $29