LRRC32 rs2495636: Understanding This Genetic Variant
The rs2495636 variant is a non-coding genetic change located in the 11q13.5 region near the LRRC32 gene. It has been studied for its potential association with immune-related traits, specifically those involving regulatory T-cell function and allergic responses.
What each genotype means
Typical LRRC32 signaling profile
This genotype represents the most common genetic configuration at this location in many populations. Research suggests this region of the LRRC32 gene may influence regulatory T-cell function, though the specific impact of this variant remains limited and requires further study. This result does not indicate a medical condition or specific health risk.
Carried by approximately 52% of individuals of European ancestry, based on a minor allele frequency of 0.28.
Varied LRRC32 signaling profile
Carrying one copy of the minor allele may slightly modulate the expression or signaling of the GARP/LRRC32 protein, which is involved in immune system regulation. Current evidence regarding the clinical significance of this variant is limited, and it is not considered a diagnostic marker for any disease. Please consult with a healthcare professional if you have concerns about immune-related health.
Carried by approximately 40% of individuals of European ancestry.
Minor allele signaling profile
This genotype represents the homozygous minor allele state at this locus. While the LRRC32 gene is known to play a role in regulatory T-cell control and allergic responses, the specific functional consequences of this variant are not well-defined in current scientific literature. This finding is not a diagnosis and should not be used to guide medical decisions.
Carried by approximately 8% of individuals of European ancestry.
What is rs2495636?
The rs2495636 variant is a single nucleotide polymorphism (SNP) located on chromosome 11. Being a non-coding variant, it does not reside within the protein-coding sequence of a gene, but rather in the surrounding regulatory regions. These regions are critical because they often act as switches that control when, where, and how much of a specific protein is produced. In the case of rs2495636, its location places it in proximity to the LRRC32 gene. Researchers study such variants to understand how subtle differences in our DNA sequence might influence the expression of nearby genes, potentially affecting biological pathways. Because this variant is non-coding, its primary interest lies in its potential to act as a regulatory element that modulates gene activity rather than altering the structure of a protein directly.
The Role of the LRRC32 Gene
The LRRC32 gene, also known as GARP (Glycoprotein A Repetitions Predominant), encodes a transmembrane protein that plays a specialized role in the immune system. It is primarily recognized for its function on the surface of activated regulatory T cells (Tregs) and platelets. Its main job is to act as a tether or carrier for latent TGF-beta, a powerful signaling molecule that helps regulate immune responses. By anchoring TGF-beta to the cell surface, LRRC32 allows these cells to control the activation and suppression of other immune cells. This mechanism is essential for maintaining immune balance and preventing excessive inflammation. Because of its role in stabilizing the regulatory program of T cells, researchers are interested in how variations near this gene might influence the efficiency of these immune-dampening processes.
Research and Evidence Strength
Current scientific evidence linking rs2495636 to specific health outcomes is considered limited. While genome-wide association studies (GWAS) have identified this region as a site of interest, the functional impact of this specific SNP remains an area of ongoing investigation. Some research suggests that variants in the 11q13.5 region may be associated with allergic phenotypes, such as asthma or atopic dermatitis, potentially by modulating the expression of LRRC32 and, consequently, the control of immune responses. However, it is important to note that a statistical association in a study does not necessarily imply a direct cause-and-effect relationship. Many factors, including other genetic variants, environmental exposures, and lifestyle, contribute to complex traits like allergies. Therefore, the evidence for rs2495636 is not currently sufficient to predict individual health outcomes or to serve as a diagnostic tool.
What You Can Do With This Information
Genetic information like that of rs2495636 is best viewed as a piece of a much larger, complex puzzle. Because the evidence for this variant is limited, it cannot be used to diagnose conditions or predict your personal risk for allergies or immune disorders. If you have concerns about your health, such as symptoms of asthma or skin conditions, the most effective approach is to consult with a qualified healthcare professional. They can evaluate your medical history, perform necessary clinical tests, and provide personalized guidance. Avoid making health decisions based solely on genetic data found in databases or reports. If you are currently taking medications for immune-related conditions, always discuss any questions regarding your treatment or dosing with your clinician or pharmacist, as they are the only ones qualified to manage your care.
How common is this variant?
The minor allele frequency for rs2495636 is approximately 0.28 in European ancestral populations, making the variant relatively common.
Frequently asked questions
Is rs2495636 a cause of asthma?
No, rs2495636 is not considered a direct cause of asthma. While some studies have looked at this region in relation to allergic traits, the evidence is limited and does not establish a definitive causal link.
Can I use this SNP to predict my allergy risk?
No, this SNP cannot be used to predict your risk of developing allergies. Complex traits like allergies are influenced by many genetic and environmental factors, and this variant's contribution is not well-defined.
What does 'non-coding' mean for this variant?
Non-coding means the variant is located in a part of the DNA that does not provide instructions for making a protein. Instead, it likely plays a role in regulating how nearby genes are turned on or off.
Should I change my medication based on this result?
No, you should never change your medication based on genetic test results. Always consult your doctor or pharmacist before making any changes to your prescribed treatment plan.
Sources & further reading
Educational information only, last refreshed 9/29/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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