HLA-B rs2523558: what the research says
This variant is associated with an increased risk of systemic sclerosis–associated interstitial lung disease.
What each genotype means
Typical risk profile
This genotype represents the common genetic background for this position in the HLA-B gene. Research indicates that this variant is associated with systemic sclerosis–associated interstitial lung disease, but the specific risk contribution of this genotype remains a subject of ongoing study. Please consult with a healthcare provider to discuss any concerns regarding autoimmune health.
Frequency data for this specific genotype is variable and depends significantly on ancestral background.
Increased risk marker
Carrying this genotype may be associated with an increased statistical risk for systemic sclerosis–associated interstitial lung disease. Because HLA-B variants are part of a complex immune system region, this association is influenced by other genetic and environmental factors. This information is for educational purposes and should not be used for medical diagnosis.
Frequency data for this specific genotype is variable and depends significantly on ancestral background.
Increased risk marker
Carrying this genotype may be associated with an increased statistical risk for systemic sclerosis–associated interstitial lung disease. Because HLA-B variants are part of a complex immune system region, this association is influenced by other genetic and environmental factors. This information is for educational purposes and should not be used for medical diagnosis.
Frequency data for this specific genotype is variable and depends significantly on ancestral background.
Variable
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This variant is located in the HLA-B region and is associated with immune response variability and susceptibility to various autoimmune conditions.
Variant in the HLA-B locus associated with immune response and inflammatory disease susceptibility.
Variant residing within the human leukocyte antigen complex associated with autoimmune disorders and differential immune response.
Variant in the HLA-B region associated with immune response and drug hypersensitivity reactions.
Cross-ancestral HLA locus variant conferring consistent risk for oropharyngeal carcinoma across European and admixed ancestry cohorts.
This SNP is located in the 3' region of the HLA-B gene and is associated with HIV-1 controller phenotypes.