APOE rs34342646: what the research says
Located in the APOE region, this SNP is associated with Alzheimer's disease pathology and end-of-life traits as identified by Genomic Informational Field Theory.
What each genotype means
Typical APOE region profile
This genotype is the common state at this position within the APOE region. While this region is well-known for its influence on Alzheimer's disease risk, this specific SNP is considered a rare variant with limited evidence regarding its individual impact. Statistical associations found in research studies do not predict individual health outcomes.
This is the most common genotype for this variant in most populations.
Associated with trait variation
Carrying one copy of the G allele at this position has been associated with Alzheimer's disease pathology and end-of-life traits in recent genomic studies. Because this variant is in the APOE region, it is often studied alongside other known genetic factors that influence cognitive aging. Please speak with a healthcare provider if you have questions about your genetic risk profile.
This genotype is rare to low frequency, depending on the specific ancestral population.
Rare APOE variant genotype
This genotype is a rare configuration at this position. Research using genomic informational field theory has identified this variant as having a potential association with Alzheimer's disease pathology, though the evidence is currently limited. These findings are based on population-level data and are not diagnostic for any individual.
This genotype is rare and observed infrequently in most global populations.
Rare to low frequency depending on population.
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This variant in the APOE region has been identified as significantly associated with Alzheimer's disease pathology and end-of-life traits.
Together with rs7412, the C allele at rs429358 establishes the APOE epsilon 4 haplotype, conferring dose-dependent susceptibility to late-onset Alzheimer disease and cardiovascular disease.
Non-coding regulatory variant in APOE strongly associated with cognitive healthspan, survival past 90, and lipid homeostasis.
This variant (c.548G>C, p.Gly183Ala) in the APOE gene is classified as likely pathogenic and is associated with familial type 3 hyperlipoproteinemia (dysbetalipoproteinemia).
This variant in the APOE locus has been identified as a significant marker associated with Alzheimer's disease neuropathology using genomic informational field theory.
Variant in the APOE/TOMM40 locus associated with late-onset Alzheimer's disease risk.