SPIRE2 rs35096708: What Your Genotype Means
The rs35096708 variant is a single nucleotide polymorphism located within the SPIRE2 gene. It has been identified in genome-wide association studies as a potential marker associated with quantitative measurements of skin aging.
What each genotype means
Typical skin aging profile
This genotype represents the homozygous state for the A allele at the rs35096708 locus. Research indicates this variant is associated with skin aging measurements, though specific clinical implications for this genotype remain limited and require further study.
Frequency data for this specific genotype is not widely established across global populations.
Typical skin aging profile
This genotype represents the heterozygous state for the rs35096708 variant. While this SNP has been identified in genome-wide association studies as a marker linked to skin aging, the functional impact of carrying one copy of each allele is not currently well-defined in clinical literature.
Frequency data for this specific genotype is not widely established across global populations.
Typical skin aging profile
This genotype represents the homozygous state for the G allele at the rs35096708 locus. This variant is recognized in the GWAS Catalog for its association with skin aging traits, but it is not considered a diagnostic marker and does not imply a specific medical condition.
Frequency data for this specific genotype is not widely established across global populations.
Understanding the Variant
The rs35096708 variant is a specific change in the DNA sequence located on chromosome 16. In the context of genomics, a single nucleotide polymorphism (SNP) represents a variation at a single position in the DNA chain, where one nucleotide—the building block of DNA—is replaced by another. For rs35096708, the variation involves the nucleotides adenine (A) and guanine (G). This SNP is cataloged in major genetic databases, including dbSNP, and has been highlighted in research investigating the genetic architecture of skin-related traits. Because it is located within the SPIRE2 gene, researchers have investigated whether this specific location influences biological processes that might manifest as observable differences in skin characteristics over time.
The Role of the SPIRE2 Gene
The SPIRE2 gene encodes a protein known as Spire type actin nucleation factor 2. This protein plays a critical role in cellular architecture by organizing actin assembly, which is essential for maintaining the structural integrity and shape of cells. Beyond its structural role, SPIRE2 is involved in processes such as meiotic spindle localization, which is vital for proper cell division. While the primary functions of SPIRE2 are well-documented in cellular biology, its specific contribution to skin aging is a subject of ongoing scientific inquiry. Researchers hypothesize that because actin dynamics are fundamental to cell health and structural maintenance, variations in genes like SPIRE2 could theoretically influence how skin cells respond to environmental stressors or maintain their structural properties as an individual ages.
Research and Evidence Strength
The association between rs35096708 and skin aging is derived from genome-wide association studies (GWAS). These studies scan the entire genome to identify statistical links between specific genetic variants and physical traits. The evidence for rs35096708 is currently considered moderate. While it has been flagged in studies exploring skin aging measurements, it is important to note that skin aging is a complex, polygenic trait. This means it is influenced by hundreds, if not thousands, of genetic variants, as well as significant environmental factors like sun exposure, nutrition, and lifestyle. A statistical association in a GWAS does not imply a direct cause-and-effect relationship, and the effect size of any single SNP on the overall appearance of skin is typically very small. Further research is required to fully understand the biological mechanism, if any, connecting this specific variant to skin aging.
Population Frequency and Interpretation
Information regarding the specific population frequency of the rs35096708 variant is limited in current public databases. Genetic variants often show significant differences in frequency across various ancestral populations, and without comprehensive data, it is difficult to determine how common this SNP is globally. When interpreting genetic information, it is essential to remember that having a particular genotype does not determine one's future health or physical appearance. Genetic markers are probabilistic, not deterministic. Because the evidence linking rs35096708 to skin aging is based on statistical correlations, it should not be used to predict individual outcomes. Consumers should view such information as a small piece of a much larger, complex biological puzzle rather than a definitive indicator of personal traits.
What You Can Do With This Information
Accessing genetic data can be an educational experience, but it is important to maintain a realistic perspective on what this information means. You cannot use the rs35096708 genotype to diagnose skin conditions or predict the rate at which your skin will age. Because skin aging is heavily influenced by external factors, the most effective ways to support skin health remain well-established practices, such as using sun protection, maintaining a balanced diet, and staying hydrated. If you have specific concerns about your skin health, such as changes in texture, pigmentation, or signs of damage, the most appropriate course of action is to consult a board-certified dermatologist. They can provide professional assessments and evidence-based recommendations tailored to your individual needs, which are far more reliable than insights derived from a single genetic variant.
How common is this variant?
Specific population frequency data for rs35096708 is not currently well-documented in major public genomic databases.
Frequently asked questions
Can I use this SNP to predict if I will get wrinkles?
No. Skin aging is a complex process influenced by many genes and significant environmental factors like sun exposure and lifestyle. A single SNP cannot predict your personal skin aging trajectory.
Is rs35096708 a 'bad' gene variant?
No. Genetic variants are simply differences in DNA sequences. Most variants, including this one, are considered neutral and are part of the natural genetic diversity found in humans.
Where can I find more information about my own genotype?
If you have taken a direct-to-consumer genetic test, you may be able to find your raw data file. You can then search for the rsID in that file, though interpreting the results should be done with caution.
Does this variant affect my risk of skin cancer?
There is no evidence suggesting that rs35096708 is a marker for skin cancer risk. Always consult a dermatologist for any concerns regarding skin lesions or cancer screenings.
Sources & further reading
Educational information only, last refreshed 9/27/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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Pleiotropic locus on chromosome 16q24.3 associated with facial pigmented spots, solar lentigines, and cutis laxa characteristics.
Variant in the 16q24.3 region associated with facial wrinkle grade, photoaging scores, and differential cutaneous actin dynamics.