rs35267671 and LOC129930172: Understanding Genetic Associations
The genetic variant rs35267671 is located within the genomic region identified as LOC129930172. Research has associated this specific variant with variations in monocyte counts and the risk of myocardial infarction.
What each genotype means
Typical monocyte count profile
This genotype is considered the common or reference state for this variant. Research indicates that this variant is associated with variations in monocyte counts and potential risk for myocardial infarction, but these associations are based on population-level statistical trends rather than individual clinical outcomes. This information is for educational purposes and does not constitute a medical diagnosis.
Specific frequency data for this genotype is not currently recorded in public databases.
Associated with trait variation
Carrying one copy of the variant allele is associated with statistical differences in monocyte counts and myocardial infarction risk in some studies. Because these findings are based on broad population associations, they cannot predict your personal health outcomes. Please consult with a healthcare professional if you have concerns about your cardiovascular health or blood cell counts.
Specific frequency data for this genotype is not currently recorded in public databases.
Associated with trait variation
Carrying two copies of the variant allele is associated with statistical differences in monocyte counts and myocardial infarction risk in some studies. These associations are derived from large-scale genomic research and do not imply a direct cause-and-effect relationship for any individual. You should discuss any health-related questions or cardiovascular risk factors with your primary care physician.
Specific frequency data for this genotype is not currently recorded in public databases.
What is rs35267671?
The identifier rs35267671 refers to a single nucleotide polymorphism (SNP), which is a variation at a single position in the DNA sequence. This specific SNP is situated within a region designated as LOC129930172. In genomics, LOC identifiers are often used for uncharacterized or newly identified functional elements. According to current genomic databases, this region has been validated as an accessible chromatin area that functions as a silencer, meaning it can help regulate gene expression by repressing certain promoter activities. Because this variant sits in a regulatory region rather than a protein-coding gene, its primary influence is likely related to how nearby genes are turned on or off, rather than changing the structure of a protein itself. Understanding the location of such variants is a critical first step for scientists attempting to map how non-coding DNA contributes to human health and biological traits.
Understanding the Associated Traits
Genome-wide association studies (GWAS) have linked rs35267671 to two distinct phenotypes: monocyte count and myocardial infarction. Monocytes are a type of white blood cell that plays a vital role in the immune system's response to infection and inflammation. Myocardial infarction, commonly known as a heart attack, occurs when blood flow to the heart muscle is blocked. The statistical association between this variant and these traits suggests that the regulatory activity of the LOC129930172 region may influence the production or behavior of immune cells, which in turn could be involved in the inflammatory processes underlying cardiovascular health. It is important to note that these associations are based on statistical correlations observed in large populations. They do not imply that the variant is the sole cause of these conditions, as both immune cell counts and heart health are influenced by a complex interplay of many genetic factors, environmental exposures, and lifestyle choices.
Strength of Evidence and Research Context
The evidence linking rs35267671 to monocyte counts and myocardial infarction is categorized as moderate. In the context of genetic research, a moderate strength of evidence typically means that while multiple studies have identified a signal, the biological mechanism connecting the variant to the clinical outcome is still being investigated. GWAS data provides a snapshot of associations, but these findings often require further functional validation to confirm exactly how the variant exerts its effect. Because this variant is located in a regulatory element, researchers must perform complex experiments to determine which specific genes are being regulated and how that regulation impacts cellular function. As with many findings in the GWAS Catalog, these results are intended to guide future research into disease mechanisms rather than to serve as definitive clinical predictors. The scientific community continues to refine these associations as more diverse genomic data becomes available.
What You Can Do With This Information
Information about genetic variants like rs35267671 is primarily intended for educational and research purposes. If you have received information about your own genotype for this variant, it is important to understand that this does not constitute a medical diagnosis or a prediction of future health. Genetic associations are probabilistic, not deterministic, and they represent only a small fraction of the factors that influence your health. You cannot use this information to make decisions about medications or lifestyle changes without consulting a healthcare professional. If you are concerned about your cardiovascular health or immune function, the most effective approach is to discuss your family history, symptoms, and clinical test results with your doctor. They can provide personalized guidance based on established medical standards, which are far more reliable than individual SNP associations for managing your health and well-being.
How common is this variant?
Specific population frequency data for rs35267671 is not currently recorded in major public databases. Frequency can vary significantly across different ancestral groups, and further research is needed to establish global prevalence.
Frequently asked questions
Is rs35267671 a cause of heart attacks?
No, rs35267671 is not considered a direct cause of heart attacks. It is a genetic variant that has shown a statistical association with myocardial infarction risk in large studies, meaning it is one of many factors that may contribute to overall risk.
Can I use this SNP to predict my monocyte count?
No, you cannot use this SNP to predict your monocyte count. While the variant is associated with variations in monocyte levels, many other genetic and environmental factors determine your actual blood cell counts.
Where can I find more information about LOC129930172?
You can find more information about this region on the GeneCards website or through the NCBI Gene database. These resources provide technical summaries of functional elements and their known genomic roles.
Should I be worried if I have the G allele?
There is no reason to be worried based on a single genetic variant. Genetic associations are complex and should be discussed with a healthcare provider who can evaluate your overall health profile.
Sources & further reading
Educational information only, last refreshed 9/16/2026. Not medical advice — these associations describe population statistics, not individual predictions.
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